FAQ-436
Can RNAi experiments be performed in Drosophila?
Yes. Below are a few selected references you can review:
- Elbashir SM, Martinez J, Patkaniowska A, Lendeckel W, Tuschl T. "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate." EMBO J. 2001, 20 (23): 6877-88
- Zamore PD, Tuschl T, Sharp PA, Bartel DP. "RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals." Cell. 2000, 101 (1): 25-33
- Williams RW, Rubin GM. "ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos." Proc Natl Acad Sci U S A. 2002, 99 (10): 6889-94
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HP Custom siRNA
HP Custom siRNA is an siRNA synthesis option that provides for specific siRNA requirements, including siRNA for multiple species, specific splice variants, and non-human, -mouse, and -rat genes. HP Custom siRNA provides highly pure siRNA in 20 nmol amounts. Available fluorescent labels include Alexa Fluor 488, Alexa Fluor 546, Alexa Fluor 555, Alexa Fluor 647, Cyanine 570, Cyanine 670, fluorescein, and rhodamine dyes. Modification options include amino linkers, thio linkers, and biotin, dabcyl, and phosphate modifications.