Features
- Fully automated purification of high-quality nucleic acids, including reagent pipetting and magnetic separation, ideal for sensitive downstream analyses
- High process safety with automated pre-run inventory checks and sealed reagent cartridges
- Flexible throughput of 1 to 96 samples, with input volumes ranging from microliters up to 10 mL
- End-to-end sample traceability with automated barcode tracking of sample and eluate IDs
- Intuitive software with guided setup and flexibility for both standardized and custom workflows
- Convenient connectivity with QIAsphere and LIMS integration*
- IVD-compliant for use in diagnostic settings
Product Details
The QIAsymphony Connect is an automated system for nucleic acid purification using magnetic particle technology "(Figure 1. QIAsymphony Connect workflow using magnetic particles)". It builds on the proven performance of the classic QIAsymphony platform and automates all steps of the extraction workflow, including lysis, binding, washing and elution, helping reduce hands-on time and improve consistency from run to run.
Ideal for use in regulated environments with in vitro diagnostic (IVD) extraction workflows, the system supports reliable processing of a wide range of sample types, including challenging and low-input materials, and enables efficient batch purification to help laboratories manage increasing sample volumes and complexity "(Figure 2. Tube carrier)". Primary tube handling, built-in barcode tracking and automated process control support end-to-end sample and process traceability, while central user management and seamless connectivity with LIMS and QIAsphere improve efficiency. Enhanced extraction performance and a new elution process help maximize nucleic acid recovery and concentration "(Figure 3. Magnetic plate)", supporting high-sensitivity applications such as liquid biopsy and precision oncology assays "(Figure 4. Eluate drawer)".
Choose between QIAGEN-validated workflows or customizable protocols to tailor nucleic acid extraction to your needs. For IVD applications, the validated extraction workflows support consistent performance and regulatory compliance. Guided, software-controlled maintenance and an easy-to-clean workdeck help maintain system integrity, while prefilled reagent cartridges and consumables reduce the risk of contamination "(Figure 5. Prefilled reagent cartridges)".
Performance
The QIAsymphony Connect delivers consistent, high-quality nucleic acid purification across an expanding range of sample types, including challenging and low-input clinical materials. Automated, protocol-driven processing helps ensure reproducible yields and minimizes variability between runs and operators. The system supports reliable downstream performance in sensitive applications such as dPCR and NGS by providing nucleic acids of consistent yield, quality and purity, while efficient batch processing enables laboratories to manage routine and higher-throughput workflows with confidence.
Consistent nucleic acid yield and quality: Our novel bead collection process guarantees high nucleic acid yields by reducing the dead volume during elution, enabling sensitivity of downstream assays.
End-to-end traceability and digital integration: Automated barcode tracking from sample to eluate, camera-based inventory scans, run reports and LIMS connectivity, supports greater process safety.
Speed and efficiency: A dedicated lysis station enables fast lysis, the magnetic plate design speeds up bead collection and built-in cameras provide sample traceability and quick load checks.
Intuitive operation and quick onboarding: Minimal hands-on time with simple “load-and-go” operation, optimized workflows and an easy-to-use interface reduce training requirements.
Flexible and scalable workflows: Supports a wide range of sample types, including liquid biopsy, with adaptable input volumes and application flexibility.
Principle
The QIAsymphony Connect uses magnetic particle technology to automate nucleic acid purification. Most samples are lysed in an integrated lysis station with controlled heating and shaking, after which nucleic acids bind to magnetic particles and are transferred through a series of wash steps to remove contaminants before final elution. An array of magnetic rods enables controlled capture and movement between reagent wells, supporting efficient batch processing of up to 24 samples in parallel. Integrated liquid handling and automated mixing ensure consistent conditions throughout the workflow, enabling reliable purification of DNA and RNA from a wide range of sample types. The system is designed to support labs with hands-off, pre-optimized and controlled extraction workflows for reliable and reproducible extraction. Integrated liquid handling, magnetic separation and robotic transfer enable precise, automated processing within a closed system. Built-in barcode scanning and inventory management support accurate sample tracking and correct loading of consumables, while the intuitive touchscreen interface provides real-time system control and workflow visibility.
| Extraction technology | Magnetic particle with on-board liquid handling |
| Automation features | Robotic handling system Controlled heating, cooling and shaking Reagent and consumable inventory scan Integrated waste management |
| Sample types | A wide range of sample types is supported, depending on the kit selected, with new kits and applications continually expanding your options |
| Sample input volume | From microliters up to 10 mL |
| Dimensions | Instrument: 130 x 105 x 80 cm, cabinet 130 x 86 x 75 |
| Power | 100–240 V AC, 50/60 Hz, 500VA |
| Overvoltage category | II |
| Place of operation | For indoor use only |
|
Weight (fully loaded) |
245 kg |
|
Weight incl Cabinet (fully loaded) |
420 kg |
Procedure
- Sample loading: Samples are loaded into the sample drawer using appropriate tube carriers, along with required controls.
- Reagent and consumable setup:Kit-specific reagents, cartridges and consumables are loaded, and an automated inventory scan verifies correct placement and quantity.
- Run setup: Protocols are selected via the touchscreen or QIAsymphony Connect Software Suite using guided or flexible setup options.
- Automated purification: The system performs lysis, binding of nucleic acids to magnetic particles, washing and elution without further user intervention.
- Eluate collection: Purified nucleic acids are transferred to the eluate drawer for immediate downstream applications or storage.
- Easy transition: Switching from the widely used QIAsymphony SP is straightforward, as both systems use the same QIAsymphony kits and consumables.
Applications
The QIAsymphony Connect supports a broad range of nucleic acid purification workflows across clinical and research settings:
Clinical and IVD applications
In combination with specific kits, the system automates nucleic acid purification across IVD, pharmaceutical, forensic and research workflows*
Oncology and precision medicine applications
Liquid biopsy and circulating nucleic acid analysis
Infectious disease testing and surveillance
Research applications
Translational and biomarker research
Academic and industrial research workflows across diverse sample types
Microbiome research
Human identification and forensics
Downstream assay technologies
qPCR
Digital PCR (dPCR)
Next-generation sequencing (NGS)
Other nucleic acid-based analyses requiring consistent input quality
*Not all applications are currently available; compatibility depends on the kit used, with new applications introduced over time.
Software
The QIAsymphony Connect is operated via an intuitive touchscreen interface that provides guided and flexible workflow setup, run monitoring and access to system status and maintenance tools. The software supports standardized operation through protocol-driven workflows, integrated user management and role-based access control. Built-in barcode tracking enables sample and eluate traceability throughout the workflow. Connectivity options support integration with laboratory information management systems (LIMS) and digital tools such as QIAsphere, enabling data transfer, workflow monitoring and streamlined laboratory operations.
Supporting data and figures
Figure 1. QIAsymphony Connect workflow using magnetic particles
During the workflow, magnetic particles are:
- Captured from the sample using magnetic rods
- Transferred between reagents to enable washing steps
- Released and mixed to ensure efficient binding and purification
- Concentrated into a low-volume eluate for downstream applications
Kits & Consumables
Resources
Technical Information (1)
User Manuals (1)
Safety Data Sheets (1)
Certificates of Analysis (1)