Has RNAi been successful using siRNA in Zebrafish and Xenopus?
FAQ ID -400
Here are examples of references that describe the inhibition of gene expression by siRNA in Xenopus and Zebrafish:
- Wargelius A, Ellingsen S, Fjose A. Double-stranded RNA induces specific developmental defects in zebrafish embryos. Biochem Biophys Res Commun. 1999 Sep 16; 263(1): 156-61
- Zhou Y, Ching YP, Kok KH, Kung HF, Jin DY. Post-transcriptional suppression of gene expression in Xenopus embryos by small interfering RNA. Nucleic Acids Res. 2002 Apr 1; 30(7): 1664-9
- Zhao, Y Cao, M Li, and A Meng Double-stranded RNA injection produces nonspecific defects in zebrafish. Dev Biol, Jan 2001; 229(1): 215-23."