No. Factor SB of the HotStar HiFidelity Polymerase Kit is completely different from multiplex PCR enhancing Factor MP in the QIAGEN Multiplex PCR Kit. Factor SB is a novel high-fidelity PCR enhancer developed at QIAGEN. It is unique to the HotStar HiFidelity PCR Buffer. It improves the sensitivity and reliability of PCR reactions, especially when low amounts of starting template are used. Factor SB ensures that the template DNA, which is often degraded by the 3'→5' exonuclease activity of high-fidelity enzymes, remains intact.