NGS solutions for coronavirus research

Innovation-led coronavirus NGS solutions and integrated bioinformatics

Emerging pandemics require accelerated development of innovative technologies to enable faster mitigatory responses. Advances in molecular epidemiology by examining pathogen phylogenetics and virus strain evolution, as well as insights into pathogen-host-microbiome interactions and metatranscriptomics can trigger developments in phylogeographic tracking, as well as vaccine and drug discovery research. With innovation at the heart of its mission, partner with QIAGEN to benefit from the full spectrum of our high-performance NGS solutions and integrated bioinformatics pipelines that collectively drive a greater understanding of the multiple facets of SARS-CoV-2 biology.

SARS-CoV-2 epidemiology

Combatting the COVID-19 pandemic requires greater insights into the molecular epidemiology of SARS-CoV-2 to trace existing outbreaks, study viral evolution and advance vaccine and drug development research. To support these efforts, we’ve developed the new QIAseq SARS-CoV-2 Primer Panel – an NGS-based solution for targeted enrichment of the complete viral genome. Multiplex up to 384 samples using a faster workflow, and rapidly analyze your data with integrated analysis pipelines. Based on optimized publicly-available ARTIC V3 designs, the QIAseq SARS-CoV-2 Primer Panel minimizes primer dropouts and primer-dimer effects. Combine with the QIAseq FX DNA Library UDI Kit to convert amplicons into NGS-ready libraries compatible with Illumina platforms. Achieve high library complexity and maximize coverage with our optimized, single-day workflows, which are faster and have lower-input requirements compared to hybrid capture solutions.

SARS-CoV-2 metatranscriptomics

Deciphering the complex interplay between the host and its microbiota can unlock detailed insights into host, microbiome, virus and pathway responses. Highly abundant host and bacterial rRNA can be problematic in coronavirus metatranscriptomics studies, leading to wasted RNA-seq reads. To maximize unique gene expression reads, remove >95% of both host and bacterial rRNA in just 1 hour, while still retaining viral RNAs by using QIAseq FastSelect –rRNA HMR Kits and QIAseq FastSelect –5S/16S/23S Kits either separately or in combination. Then move on to stranded, high-quality library prep using the QIAseq Stranded Total RNA Lib Kit for sensitive detection of low-expression RNA molecules with increased complexity and transcript coverage. Benefit from the specificity and efficiency of the complete QIAseq workflow to expedite SARS-CoV-2 metatranscriptomics research.

Request trial kits

Special offer: Get 25% off any QIAGEN CLC Genomics NGS analysis bioinformatics software

Make sense of your coronavirus sequencing data with powerful bioinformatics analyses. With every purchase of the QIAseq SARS-CoV-2 Primer Panel Kit (96), we are offering 25% off any 1-year subscription of QIAGEN CLC Genomics software. Whether you’re studying strain evolution or performing phylogeographic or metagenomic analyses, accelerate impactful insights with our integrated bioinformatics solutions.

FIND OUT MORE

Coronavirus research publications using QIAGEN technologies

Itokawa, K., Sekizuka, T., Hashino, M., Tanaka, R., and Kuroda, M. (2020)
A proposal of an alternative primer for the ARTIC Network’s multiplex PCR to improve coverage of SARS-CoV-2 genome sequencing.
Itokawa, K., Sekizuka, T., Hashino, M., Tanaka, R., and Kuroda, M. (2020)
Disentangling primer interactions improves SARS-CoV-2 genome sequencing by the ARTIC Network’s multiplex PCR.
Maitra, A. et al. (2020)
Mutations in SARS-CoV-2 viral RNA identified in Eastern India: Possible implications for the ongoing outbreak in India and impact on viral structure and host susceptibility.
Hartley et al. (2020)
Genomic evidence for a case of reinfection with SARS-CoV-2
Tillett et al. (2020)
Genomic surveillance revealed prevalence of unique SARS-CoV-2 variants bearing mutation in the RdRp gene among Nevada patients

Coronavirus webinars

Sign up for our informative live webinars exploring different themes in coronavirus research.

Using targeted whole viral genome sequencing to understand COVID-19
Speaker: Brian Dugan, M.S., Associate Director, Global Product Management, Genomics, QIAGEN

On-demand recorded webinar
REGISTER NOW
rRNA removal for RNA-seq applications involving viruses, host responses and metatranscriptomics
Speaker: Samuel Rulli, Ph.D., Associate Director, RNA-seq profiling, NGS assay technologies, QIAGEN

On-demand recorded webinar
REGISTER NOW
Targeted RNA panels to identify SARS-CoV-2 and study host gene expression
Speaker: Samuel Rulli, Ph.D., Associate Director, RNA-seq profiling, NGS assay technologies, QIAGEN

On-demand recorded webinar
REGISTER NOW

Rely on QIAGEN Genomic Services to drive your COVID-19 research forward

Take advantage of QIAGEN Genomic Services to accelerate your COVID-19 research. From library prep and sequencing to data analysis and interpretation, our in-house experts use trusted QIAseq NGS technologies and QIAGEN Digital Insights software to deliver high-quality results you can rely on.