QIAGEN Paternity Testing Solutions

QIAGEN Paternity Testing Solutions 09/2016 7 ator STR GO! Kits for direct amplification Better quality control checks for your STR analyses Investigator 24plex Kits include an integrated quality control feature, the unique Quality Sensor, which allows the generation of additional, valuable data for performance checks. With Quality Sensor, you can confirm a successful PCR amplification and distinguish between the absence of DNA due to improper sampling and a failed PCR amplification, as well as differ- entiating between degradation and inhibition. This information can be used to choose the most appropriate rework strategy and streamline the overall workflow for direct amplification with higher first-success rates. For better quality control in your STR analysis, see www.qiagen.com/qualitysensor. Results you can trust For kinship testing, like other human identity applications, accuracy of results as well as ease of data interpretation are key. That’s why QIAGEN invests heavily in optimal primer design (Figure 6). Investigator 24plex Kits have been designed with reduced allelic overlap wherever possible. This ensures that for rare alleles, you get unambiguous results you can trust. Attaining results with better statistical relevance lowers costs by reducing reagent and material expense for reruns, saves lab time per result, and reduces time required for data analysis. Figure 6. Allele distribution comparison. A: Primer design of the Investigator 24plex Kits minimizes allelic overlap to get unambiguous results and increased statistical relevance for rare alleles. B: In contrast, the GlobalFiler® Kits (Thermo Fisher Scientific) has various allelic overlaps, which lead to an increased risk of data misinterpretation, the need to retype samples, and as a result, increased overall cost at lower statistical relevance. Marker and allele distribution according to published alleles (February 2015) is shown. A B Quality Sensor Successful PCR Failed PCR No DNA Degraded DNA Inhibited DNA

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