
A look back: TB outbreak history in US
Tuberculosis (TB), once known as “consumption,” was responsible for one of every seven deaths in the US and Europe in the early 20th century (1). TB outbreaks in the US were common in areas with poor ventilation, ineffective sanitation, malnutrition and dense living and working conditions.
US TB incidence declined sharply in the mid-20th century with the introduction of antibiotics, improvements in sanitation and the creation of dedicated public health control programs. However, TB remains a persistent threat, with recent resurgences driven by HIV co-infection, drug-resistant strains and the COVID-19 pandemic. TB exposure and transmission events still occur today, and TB testing, treatment and prevention remain critical priorities for the US CDC.
Lessons learned from public health responses
Successful public health responses to TB exposure events rely on early detection, robust treatment programs and coordinated surveillance. Investments in laboratory testing, directly observed therapy (DOT), infection control and community outreach have proved essential in containing the spread of TB. Preventing TB requires integration of new diagnostic technologies and strong partnerships across public health agencies, healthcare institutions and policymakers.
| Date | Location | Setting | Description of event | Source |
|
Jan, 2025 |
Kansas |
Community spread |
Kansas faces one of the largest tuberculosis |
|
|
Feb, 2025 |
Kalamazoo, |
Kalamazoo High School |
Active TB case confirmed; |
|
|
Feb, 2025 |
Hartsville, |
Hartsville High School |
Active TB case confirmed; |
|
|
Apr, 2025 |
Waukegan, |
Waukegan High School |
Active TB case confirmed; |
|
|
Apr, 2025 |
Fort Lauderdale, |
Dillard High School |
Active TB case confirmed; |
|
|
May, 2025 |
Portland, |
Lane Middle School |
Active TB case confirmed; |
|
|
Jul, 2025 |
Tulsa, |
McLain High School |
Active TB case confirmed; |
|
|
Jul, 2025 |
San Diego, |
Southwest High School |
TB exposure reported; |
The hidden threat: Asymptomatic TB infection
Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. Asymptomatic TB infection, also called latent tuberculosis infection (LTBI), shows no signs or symptoms and cannot be passed on to others. However, people with TB infection are at risk for progression to serious and contagious TB disease.
Why millions are infected but unaware
Millions of people are living with TB infection but are unaware because they have no symptoms. Without testing, these individuals often go undiagnosed until TB becomes active and contagious. This hidden reservoir underscores the importance of testing high-risk groups to identify infection early and reduce future transmission.
Reactivation risk and potential for TB exposures
Early detection is the first line of defense
Early detection of tuberculosis infection before it progresses to contagious active TB disease is the most effective way to stop the spread of TB. Identifying cases in the latent stage allows for timely preventative treatment and reduces the risk of transmission to others.Early detection is the cornerstone of TB prevention and long-term public health protection.
How modern TB testing helps prevent transmission events
Modern tuberculosis infection testing increasingly relies on blood-based diagnostics, which offer greater accuracy and convenience than the traditional tuberculin skin test. TB blood tests reduce false positive tests resulting from BCG vaccination and environmental mycobacterial strains, only require a single blood draw and provide objective results. By enabling early detection and treatment of TB infection, TB blood tests play an essential role in preventing progression and stopping small clusters from becoming widespread exposure events.
References
- US CDC. History of World TB Day. https://www.cdc.gov/world-tb-day/history/index.html
- US CDC. Tuberculosis – Untied States, 2023. MMWR Morb Mortal Wkly Rep 2024;73:265–270. https://restoredcdc.org/www.cdc.gov/mmwr/volumes/73/wr/mm7312a4.htm
- US CDC. 2022 ARPE contact investigations report. https://www.cdc.gov/tb-data/arpe-reports/2022-contact-investigations.html
- Furlow, B. Historic TB outbreak a wake-up call for US policy makers. Lancet 2025;13(4):E23.
- Asay GRB, Young KH, Hill TD, Njie GJ. Systematic Review of Contact Investigation Costs for Tuberculosis, United States. Emerg Infect Dis. 2025;31(7):1284-1293.


