A rapid response can prevent TB outbreaks
Tuberculosis testing

Tuberculosis outbreaks: History, recent cases and what you should know

A look back: TB outbreak history in US

Tuberculosis (TB), once known as “consumption,” was responsible for one of every seven deaths in the US and Europe in the early 20th century (1). TB outbreaks in the US were common in areas with poor ventilation, ineffective sanitation, malnutrition and dense living and working conditions.
US TB incidence declined sharply in the mid-20th century with the introduction of antibiotics, improvements in sanitation and the creation of dedicated public health control programs. However, TB remains a persistent threat, with recent resurgences driven by HIV co-infection, drug-resistant strains and the COVID-19 pandemic. TB exposure and transmission events still occur today, and TB testing, treatment and prevention remain critical priorities for the US CDC.

Lessons learned from public health responses

Successful public health responses to TB exposure events rely on early detection, robust treatment programs and coordinated surveillance. Investments in laboratory testing, directly observed therapy (DOT), infection control and community outreach have proved essential in containing the spread of TB. Preventing TB requires integration of new diagnostic technologies and strong partnerships across public health agencies, healthcare institutions and policymakers.

Recent TB outbreaks in the United States (2024–2025) 

In recent years, the US has seen a resurgence of tuberculosis. In 2023, TB case counts rose for the third consecutive year, reaching the highest incidence in over a decade (2). 

According to the CDC, more than 3000 TB contact investigations occur annually, often involving close quarters arrangements such as college dormitories, prisons and hospitals (3). An ongoing TB transmission event in Kansas is among the worst in recent US history, with at least 66 active TB cases confirmed (4). 

Recent TB outbreaks map europe and US
Global TB incidence and recent contact investigations.
 Date   Location   Setting   Description of event   Source 

 Jan, 2025

 Kansas

 Community spread  

Kansas faces one of the largest tuberculosis
 outbreaks in US history. Multiple sites, 66 active
TB cases confirmed; 79 TB infections identified since 2024. 

 abcnews.com 

 Feb, 2025 

 Kalamazoo,
 MI 

 Kalamazoo High School 

 Active TB case confirmed; 
 contacts identified for testing.

 cbsnews.com

 Feb, 2025

 Hartsville,
 SC

 Hartsville High School

 Active TB case confirmed; 
 280 tested, 56 TB infection identified.

 wpde.com

 Apr, 2025

 Waukegan,
 IL

 Waukegan High School

 Active TB case confirmed; 
 close contacts notified for screening.

 nbcchicago.com

 Apr, 2025

 Fort Lauderdale,
 FL

 Dillard High School

 Active TB case confirmed; 
 testing arranged for identified contacts.

 abcnews.go.com

 May, 2025

 Portland,
 OR 

 Lane Middle School

 Active TB case confirmed; 
 contagious period May 1; contact tracing underway.

 yahoo.com

 Jul, 2025

 Tulsa,
 OK

 McLain High School 

 Active TB case confirmed; 
 community screening clinics scheduled.

 kosu.org

 Jul, 2025

 San Diego,
 CA

 Southwest High School

 TB exposure reported; 
 students and staff notified and screened at no cost.

 countynewcenter.com

The hidden threat: Asymptomatic TB infection

Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. Asymptomatic TB infection, also called latent tuberculosis infection (LTBI), shows no signs or symptoms and cannot be passed on to others. However, people with TB infection are at risk for progression to serious and contagious TB disease. 

Why millions are infected but unaware

Millions of people are living with TB infection but are unaware because they have no symptoms. Without testing, these individuals often go undiagnosed until TB becomes active and contagious. This hidden reservoir underscores the importance of testing high-risk groups to identify infection early and reduce future transmission.

Reactivation of TB infection is a major driver of new active TB cases. Certain high-risk groups are more likely to progress from asymptomatic TB infection to active TB disease, including individuals recently infected with TB and those who are immunocompromised or immunosuppressed.

Active TB disease usually affects the lungs and can spread in the air to close contacts and people at increased risk, making proactive testing and timely intervention critical to prevent transmission and protect communities.

Reactivation risk and potential for TB exposures

Early detection of tuberculosis infection before it progresses to contagious active TB disease is the most effective way to stop the spread of TB. Identifying cases in the latent stage allows for timely preventative treatment and reduces the risk of transmission to others.Early detection is the cornerstone of TB prevention and long-term public health protection.

How modern TB testing helps prevent transmission events

Modern tuberculosis infection testing increasingly relies on blood-based diagnostics, which offer greater accuracy and convenience than the traditional tuberculin skin test. TB blood tests reduce false positive tests resulting from BCG vaccination and environmental mycobacterial strains, only require a single blood draw and provide objective results. By enabling early detection and treatment of TB infection, TB blood tests play an essential role in preventing progression and stopping small clusters from becoming widespread exposure events.

quantiferon role in exposure responses

The role of QuantiFERON-TB Gold Plus in exposure responses

QuantiFERON-TB Gold Plus can play a vital role in contact investigation by providing fast, accurate and reliable detection of TB infection. QuantiFERON supports rapid contact tracing during exposure investigation and containment efforts.

References

  1. US CDC. History of World TB Day. https://www.cdc.gov/world-tb-day/history/index.html 
  2. US CDC. Tuberculosis – Untied States, 2023. MMWR Morb Mortal Wkly Rep 2024;73:265–270. https://restoredcdc.org/www.cdc.gov/mmwr/volumes/73/wr/mm7312a4.htm 
  3. US CDC. 2022 ARPE contact investigations report. https://www.cdc.gov/tb-data/arpe-reports/2022-contact-investigations.html
  4. Furlow, B. Historic TB outbreak a wake-up call for US policy makers. Lancet 2025;13(4):E23.
  5.  Asay GRB, Young KH, Hill TD, Njie GJ. Systematic Review of Contact Investigation Costs for Tuberculosis, United States. Emerg Infect Dis. 2025;31(7):1284-1293.