HRM Technology - Key Citations

Key publications demonstrating the successful use of HRM technology

HRM technology has been successfully utilized in diverse applications as illustrated by the citations listed below.
Application Title Citation
Microbiology The use of high-resolution melting
analysis for genotyping Symbiodinium
strains: a sensitive and fast approach
Granados-Cifuentes C. and
Rodriguez-Lanetty M. (2011) Mol.
Ecol. Resour. 11.
A rapid real-time PCR/DNA
resolution melting method to
identify Prototheca species
Ricchi. M., Cammi. G., Garbarino,
C.A., Buzzini, P., Belletti, G.L., and
Arrigoni. N. (2011) J. Appl. Microbiol.
110, 27.
Detection of vancomycin-resistant
enterococci using multiplex real-time
PCR assay and melting curve analysis
Cha, C.H., An, H.K., and Kim, J.U.
(2010) Korean J Lab Med. 30, 138.
Rapid identification of maternal lineages
in common carp (Cyprinus carpio L.)
using real-time PCR and high resolution
melt-curve analysis
Haynes, G.D., Gongoraa, J., Nicholas,
F.W., and Zenger, K.R. (2009) Aquaculture,
287, 59.
Genotyping of Chlamydophila psittaci
by real-time PCR and high-resolution
melt analysis
Mitchell, S.L. et. al. (2009) J. Clin.
Microbiol. 47, 175.
Classification of fowl adenovirus
serotypes by use of high-resolution
melting-curve analysis of the hexon
gene region
Steer, P.A., Kirkpatrick, N.C., O'Rourke,
D., and Noormohammadi,
A.H. (2009) J. Clin. Microbiol. 47, 311.
Quantitative evaluation of DNA
methylation by optimization of
a differential-high resolution melt
analysis protocol
Malentacchi, F., Forni, G., Vinci, S.,
and Orlando, C. (2009) Nucleic Acids
Res., 37, 86.
Detection of MGMT promoter
methylation in normal individuals
is strongly associated with the T allele
of the rs16906252 MGMT promoter
single nucleotide polymorphism
Candiloro, I.L.M. and Dobrovic, A.
(2009) Cancer Prevention Research,
2, 862.
Methylation-sensitive high-resolution
Wojdacz, T.K., Dobrovic, A., and
Hansen, L.L. (2008) Nat Protoc.
2, 1903.
SNP genotyping Nucleoside and nucleotide analogs
select in culture for different patterns
of drug resistance in Human
Immunodeficiency Virus Types 1 and 2
Ntemgwa, M.L. et al. (2009)
Antimicrob. Agents Chemother.
53, 708.
SNP genotyping
Implication of sex and SORL1 variants
in Italian patients with Alzheimer disease
Cellini, E. et. al. (2009) Arch Neurol.
66, 1260.
Mutation analysis
ScreenClust: Advanced statistical
software for supervised and unsupervised
high resolution melting (HRM) analysis
Reja, V. (2010). Methods
(San Diego, Calif.). 4, 10.
Mutation analysis
Limited copy number-high resolution
melting (LCN-HRM) enables the
detection and identification by sequencing
of low level mutations in cancer biopsies
Do, H. and Dobrovic, A.
(2009) Mol. Cancer. 8, 82.
Mutation analysis
An investigation of the C77G
and C772T variations within
the human protein tyrosine
phosphatase receptor type C gene
for association with multiple
sclerosis in an Australian population
Szvetko, A.L. et al.
(2009) Brain Research,
1255, 148.
Mutation analysis
A high-throughput candidate gene
mutation screen in lymphoproliferative
and myeloproliferative neoplasias
Kreil, S., Hochhaus, A., Cross, N.C.P.,
and Chase, A. (2009) Leukemia Research,
33, 168.
Mutation analysis
Frequent CBL mutations associated
with 11q acquired uniparental disomy
in myeloproliferative neoplasms
Grand, F.H. et al. (2009) Blood,
113, 6182
Mutation analysis
Plasmid-borne blaSHV genes in
Klebsiella pneumoniae are associated
with strong promoters
Turner, M.S., Andersson, P., Bell, J.M.,
Turnidge, J.D., Harris, T., and Giffard
P.M. (2009) J. Antimicrob. Chemother.
64, 960.
Mutation analysis
Development of a high-resolution
melting method for mutation
detection in familial
hypercholesterolaemia patients
Whittall, R.A. et al. (2009)
Ann Clin Biochem, 10.
Mutation analysis
Analysis of blaSHV codon 238
and 240 allele mixtures using
SYBR Green high-resolution
melting analysis
Andersson, P., Harris, T., Tong,
S.T.Y.C., and Giffard, P.M. (2009)
Antimicrob. Agents Chemother.
53, 2679.
Mutation analysis High resolution melting analysis
for rapid and sensitive EGFR
and KRAS mutation detection
in formalin fixed paraffin
embedded biopsies
Do, H., Krypuy, M., Mitchell,
P.L., Fox, S.B., and Dobrovic,
A. (2008) BMC Cancer. 21, 142.