Tumor Microenvironment Analysis using NGS Workflows

Getting to grips with the tumor microenvironment with NGS workflows

Tumor microenvironment (TME) analysis is a key focus in cancer research as the TME plays a critical role in cancer development, growth and spread. The TME is made up of a complex network of cells, molecules and blood vessels surrounding a tumor. High heterogeneity within the TME remains a key obstacle in tumor profiling and understanding cancer. Due to its dynamic nature, tumor microenvironment analysis requires highly sensitive technologies to detect its specific components. NGS, with its sheer discovery power and ability to capture intricate genomic and transcriptomic details, is your best shot at deciphering the multiple molecular interactions within the TME, such as:

• Revealing and profiling rare DNA variants, CNVs and methylation patterns
• Investigating differential gene expression profiles between healthy and tumor tissue
• Analyzing the expression of lncRNAs and miRNAs to shed light on their roles as mediators of cell signaling regulation
• Assessing the comprehensive TCR repertoire to understand the immune response in the TME
• Achieving a holistic view of DNA and RNA with multiomic profiling
• Evaluating microbial diversity and its impact on the TME

TME components