How to capture low-level virus-cell interactions with Protein Interaction Coupling (PICO) technology
Zoonotic viruses, such as influenza A, can overcome species barriers to pose a serious threat to human health. Understanding the entry mechanism of these viruses is essential to grasping their full tropism and zoonotic potential. But efforts to identify virus-cell interactions are frequently impeded as these interactions take place at very low levels.
In this webinar, join Prof. Dr. Martin Schwemmle from University of Freiburg, as he discusses his Nature publication on identifying the entry mediator for bat influenza A viruses in multiple species, using PICO technology.
The webinar will cover:
- PICO as a protein-protein interaction approach based on digital PCR
- How PICO and other methods were used to identify and confirm MHC class II proteins as mediators of cross-species entry of bat influenza viruses
- Future directions for PICO technology and viral research