Why does the Allprep DNA/RNA 96 Kit use Buffer RLT, whereas the AllPrep DNA/RNA Mini Kit uses Buffer RLT Plus?

The main difference between these buffers is that Buffer RLT Plus contains additional detergents. Buffer RLT Plus is optimized for efficient binding of DNA to the AllPrep DNA spin column. However, the AllPrep DNA 96 plate in the Allprep DNA/RNA 96 Kit behaves slightly different than the AllPrep DNA spin column in the AllPrep DNA/RNA Mini Kit, and achieves better specificity with Buffer RLT.




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