Cell therapy overview
Cell therapy involves the transfer of functional cells that can be modified outside the body into patients. These cells can be from the patient (autologous) or a donor (allogeneic). This includes CAR-T cells, for which quality control is vital for their effectiveness.
dPCR improves the precise quantification of modifications in these therapeutic cells, leading to accurate control over gene editing events. It also helps detect contaminating DNA, guaranteeing its safety and purity and ensuring reproducibility in lentivirus and CAR-T cell therapy production. It is also essential for detecting minimal residual disease (MRD) in cancer therapy, scanning therapy-related biomarkers and providing quality control during manufacturing.
Cell therapy workflow
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Resources for cell therapy applications
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