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COSMIC

Catalogue of Somatic Mutations in Cancer

Features

  • Cited more than 10,000 times
  • Curated knowledge from more than 28,000 peer-reviewed publications
  • Genome-wide screen data from more than 38,000 genomes
  • More than 38 million somatic mutations
  • Cancer Mutation Census

Products

The COSMIC is intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
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COSMIC

Cat. No. / ID: 834332

License for non-profit organizations who engage in patient testing or for commercial organizations. Access, download, and mine COSMIC's core data consisting of over 1.4 M cancer samples and over 38M somatic coding mutations. In addition, download and mine focused projects such as the Cancer Mutation Census and Actionability.
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COSMIC Internal R&D, Academic Lab

Cat. No. / ID: 834368

Download, mine and use COSMIC's "Cancer Mutation Census" and "Actionabiltiy" for internal research and development purposes. Access for a single named user for one academic lab.
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COSMIC Internal R&D, Academic Dept

Cat. No. / ID: 834369

Download, mine and use COSMIC's "Cancer Mutation Census" and "Actionabiltiy" for internal research and development purposes. Access for ten named users in a department.
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COSMIC Internal R&D, Academic Institute

Cat. No. / ID: 834370

Download, mine and use COSMIC's "Cancer Mutation Census" and "Actionabiltiy" for internal research and development purposes. Access for all users within the academic institute.

Product Details

COSMIC is the gold standard database for somatic mutation information.

Performance

COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the most detailed and comprehensive resource for exploring the effect of somatic mutations in human cancer. In addition to coding mutations, COSMIC covers all the genetic mechanisms by which somatic mutations promote cancer, including non-coding mutations, gene fusions, copy-number variants and drug-resistance mutations.
The core COSMIC database is complemented by additional datasets that allow users to contextualize their detected biomarkers.
1. Cancer Gene Census presents an in-depth catalogue of all 723 genes that are causally implicated in cancer, along with their biological function and the description of their genetic mechanisms driving cancer.
2. Cancer Mutation Census provides information on the mutation significance of all coding mutations based on biological and biochemical information from multiple sources.
3. Mutation Actionability in Precision Oncology (Actionability) provides up-to-date information about drugs that target specific somatic mutations at all stages of development.
4. Cell Lines Project puts forward cell line 'omics data through systematic characterization of the genetics and genomics (alterations and gene expression) of 1020 cancer cell lines.

Principle

COSMIC data are carefully selected, collected and standardized through manual curation by scientific experts, ensuring high quality, accuracy and descriptive data capture.

Procedure

COSMIC data are available as download files, ready for you to integrate into your current pipelines and tools. You also will get access to any updates released during the subscription period of one year, as well as access to our support team.

Applications

COSMIC provides curated knowledge about somatic mutations in cancer for a wide range of applications, including the following:
• Discover potential drug targets and biomarkers for cancer.
• Improve cohort selection for clinical trials.
• Identify driver mutations and relevant genes to support patient diagnosis.

Publications

COSMIC: the Catalogue Of Somatic Mutations In Cancer.
Tate JG; Bamford S; Jubb HC; Sondka Z; Beare DM; Bindal N; Boutselakis H; Cole CG; Creatore C; Dawson E; Fish P; Harsha B; Hathaway C; Jupe SC; Kok CY; Noble K; Ponting L; Ramshaw CC; Rye CE; Speedy HE; Stefancsik R; Thompson SL; Wang S; Ward S; Campbell PJ; Forbes SA;
Nucleic Acids Res; 2019; 47 (D1):D941-D947 2019 Jan 8 PMID:30371878
The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers.
Sondka Z; Bamford S; Cole CG; Ward SA; Dunham I; Forbes SA;
Nat Rev Cancer; 2018; 18 (11):696-705 2018 Nov PMID:30293088