Unlock KRAS G12C for lung cancer treatment decisions
Oncology │ KRAS

Unlock KRAS G12C for lung cancer treatment decisions

KRAS G12C – the key to a new treatment option

In Europe, lung cancer is the second commonest cancer in males and third commonest in females with >477,500 new cases in 2020 (1). Non-small cell lung cancer (NSCLC) accounts for between 80 and 90% of these cases (2). The specific mutation KRAS G12C is present in 13–15% of NSCLC cases (3, 4) and, until recently, there has been no targeted treatment for KRAS G12C-positive NSCLC, despite decades of research.

The therascreen KRAS RGQ PCR Kit is a clinically validated in vitro diagnostic (IVD) test to identify NSCLC patients that may be eligible for the new treatment LUMYKRAS (sotorasib) based on the detection of the KRAS G12C mutation.

  • Introduction to NSCLC
  • The importance of KRAS G12C in NSCLC
  • Introducing the therascreen KRAS RGQ PCR test
  • The therascreen KRAS RGQ PCR Kit
    The therascreen KRAS RGQ PCR Kit
  • The Rotor-Gene Q MDx instrument and Rotor-Gene AssaManager software
    rotor gene assay manager
  • Introduction to NSCLC
    Introduction to NSCLC
  • The importance of KRAS G12C in NSCLC
    The importance of KRAS G12C in NSCLC
  • Introducing the therascreen KRAS RGQ PCR test
    Introducing the therascreen KRAS RGQ PCR test
  • The therascreen KRAS RGQ PCR Kit
    The therascreen KRAS RGQ PCR Kit
  • rotor gene assay manager
    The Rotor-Gene Q MDx instrument and Rotor-Gene AssaManager software
Reliably detect the KRAS mutation that matters

The therascreen KRAS RGQ PCR Kit is a unique molecular test, based on the detection of specific KRAS mutations in tumor DNA isolated from formalin-fixed paraffin-embedded (FFPE) NSCLC tumor tissue. The kit targets seven mutations in codons 12 and 13 of the KRAS gene (G12A, G12D, G12R, G12C, G12S, G12V and G13D).

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KRAS mutations
Clinical patient
Making precision healthcare possible

We understand that you need to access relevant genomic information for every patient. Our therascreen kits cover a wide range of solid tumors, so that you can make the best treatment decisions possible.

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References
1. GLOBOCAN  2020. http://gco.iarc.fr/today. Accessed: January 17, 2022.
2. ESMO. Non-Small Cell Lung Cancer. ESMO Patient Guide Series.  esmo.org. Accessed: January 17, 2022
3. Biernacka, A., et al. (2016) Cancer Genetics. S2210-7762, 30021.
4. Sebastian, M., et al. (2021) Lung Cancer. 154, 51.

The therascreen KRAS RGQ PCR Kit is intended for in vitro diagnostic use.