Products:

• miRCURY LNA miRNA miRNome PCR Panels
• miRCURY LNA miRNA Focus PCR Panels
• miRCURY LNA miRNA Custom PCR Panels
• miRCURY LNA miRNA PCR Starter Kit
• miRCURY LNA RT Kit
• miRCURY LNA SYBR Green PCR Kits
• miRCURY LNA miRNA PCR Assays
• miRCURY LNA miRNA Custom PCR Assays

Resources:

• miRCURY LNA miRNA PCR – Exosomes, Serum/Plasma and Other Biofluid Samples Handbook
• miRCURY LNA miRNA PCR Handbook
• miRCURY LNA miRNA PCR System Product Profile
• Explore the RNA Universe! Poster
• miRCURY LNA miRNA PCR Assays and PCR Panels Quick-Start Protocol
• miRCURY LNA RT Kit Quick-Start Protocol

Publications:

• Park, J. et al. (2018) Expression profile of microRNAs following bone marrow‑derived mesenchymal stem cell treatment in lipopolysaccharide‑induced acute lung injury. Experimental and Therapeutic Medicine.
• Joris, V. et al. (2018) MicroRNA-199a-3p and MicroRNA-199a-5p take Pprt to a redundant network of regulation of the NOS (NO Synthase)/NO pathway in the endothelium. Arterioscler Thromb Vasc Biol.
• Catapano, F. et al. (2018). Downregulation of miRNA-29, -23 and -21 in urine of Duchenne muscular dystrophy patients. Future Medicine.
  Koutsioumpa, M. et al. (2018) MKAD-21 suppresses the oncogenic activity of the miR-21/PPP2R2A/ERK molecular network in bladder cancer. Molecular Cancer Therapeutics.
• Kung, L.H.W. et al. (2017) Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis. Osteoarthritis and Cartilage.
• Stein, E. et al. (2017) Steps to achieve quantitative measurements of microRNA using two step droplet digital PCR. PLoS One. 

Resources:

QIAseq miRNA Library QC PCR Panel and Assays (formerly Exiseq NGS Sample QC Kit Small RNA/microRNA #800101–800105

• QIAseq miRNA Library QC PCR Handbook
• QIAseq miRNA Library QC Spike-Ins Quick-Start Protocol
• Explore the RNA Universe! Poster

QIAseq miRNA Library Kit

• QIAseq miRNA Library Handbook
• QIAseq miRNA Library Kit Quick-Start Protocol Part 1 (Protocols, Part 1: 3’ Ligation, 5’ ligation, Reverse-Transcription)
• QIAseq miRNA Library Kit Quick-Start Protocol Part 2 (Protocols, Part 2: QMN Bead Preparation, cDNA Cleanup, Library Amplification)
• QIAseq miRNA Library Kit Quick-Start Protocol Part 3 (Protocols, Part 3: Library Cleanup, miRNA Library Pre-Sequencing QC, Determining Library 
• Explore the RNA Universe! Poster
• QIAseq miRNA Library Kit Product Profile 
• Frequently asked question

Publications:

• Franklin, O. et al. (2018) Plasma micro-RNA alterations appear late in pancreatic cancer. Annals of Surgery.
• Note: Uses multiple LNA technology kits, including QIAseq miRNA Library QC Spike-ins and Human Panel I, V5, miRCURY LNA miRNA miRNome PCR Panel
• Decmann, A. et al. (2018) MicroRNA expression profiling in adrenal myelolipoma. The Journal of Clinical Endocrinology & Metabolism.
• Zhou, Y. et al. (2018) Exosomes from endothelial progenitor cells improve the outcome of a murine model of sepsis. Molecular Therapy.
• Janaszak-Jasiecka, A. et al. (2018) eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells. Angiogenesis.

Resources:

QIAseq UPX 3’ Transcriptome Kits

• QIAseq UPX3' Transcriptome Handbook
• QIAseq UPX 3' Transcriptome Library Kit Quick-Start Protocol (Part 1): Cell lysis and reverse transcription
• QIAseq UPX 3' Transcriptome Library Kit Quick-Start Protocol (Part 2): Template amplification and fragmentation, end-repair and A-addition
• QIAseq UPX 3' Transcriptome Kit Product Profile
• Template: Setup custom library prep kit in BaseSpace Sequence Hub (NextSeq)

QIAseq UPX 3’ Targeted RNA Panels

• QIAseq UPX 3' Targeted RNA Library Handbook
• QIAseq UPX3' Targeted RNA Panel Quick-Start Protocol (Part 1): Cell lysis, reverse transcription 
• QIAseq UPX 3' Targeted RNA Panel Quick-Start Protocol (Part 2): Single primer extension
• QIAseq UPX 3' Targeted RNA Panel Product Profile
• Template Set A: Setup custom library prep kit in BaseSpace Sequence Hub (NextSeq)
• Template Set B: Setup custom library prep kit in BaseSpace Sequence Hub (NextSeq)
• Template Set C: Setup custom library prep kit in BaseSpace Sequence Hub (NextSeq)
• Template Set D: Setup custom library prep kit in BaseSpace Sequence Hub (NextSeq)

Publications:

• Malinska, D. et al. (2018) Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes. Food and Chemical Toxicology.
• Kaur, S. et al. (2018) A function-blocking CD47 antibody modulates extracellular vesicle-mediated intercellular signaling between breast carcinoma cells and endothelial cells. Journal of Cell Communication and Signaling.
• Dobbs, K. et al. (2017) Monocyte dysregulation and systemic inflammation during pediatric falciparum malaria. JCI Insight.

Products:

• Antisense LNA GapmeRs 
• Antisense LNA GapmeR Custom Plate

Resources:

• Antisense LNA GapmeR Design Tool Guide
• Antisense LNA GapmeR Design Tool Guide
• Antisense LNA GapmeRs Handbook

Publications:

• Forrest, M. et al. (2018) Colon cancer-upregulated long non-coding RNA lincDUSP regulates cell cycle genes and potentiates resistance to apoptosis. Scientific Reports.
• Polovic, M. et al. (2018) Identification of a novel lncRNA induced by the nephrotoxin ochratoxin A and expressed in human renal tumor tissue. Cellular and Molecular Life Sciences.
• Zhang, X. et al. (2018) Long non-coding RNA malat1 regulates angiogenesis in hindlimb ischemia. International Journal of Molecular Sciences.
• Mondal, T. et al. (2018) Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory axis. Cancer Cell.
• De Clara, E. et al. (2017) Long noncoding RNA expression profile in cytogenetically normal acute myeloid leukemia identifies a distinct signature and a new biomarker in NPM1-mutated patients. Haematologica.

Resources:

• miRCURY LNA miRNA Inhibitors and Power Inhibitors
• Custom miRCURY LNA Inhibitors and Power Inhibitors
• miRCURY LNA miRNA Family Power Inhibitors
• miRCURY LNA miRNA Target Site Blockers
• miRCURY LNA miRNA Inhibitors and Target Site Blockers Handbook

miRCURY LNA miRNA Inhibitor Libraries

• miRCURY LNA miRNA Inhibitor Libraries Handbook
• Explore the RNA Universe! Poster

miRCURY LNA miRNA Mimics

• miRCURY LNA miRNA Mimics Handbook
• Explore the RNA Universe! Poster 

Publications:

• Besharat, Z.M. et al. (2018) Foxm1 controls a pro-stemness microRNA network in neural stem cells. Scientific Reports. (Inhibitors)
• Wang, Z. et al. (2018) Parasitic insect-derived miRNAs modulate host development. Nature Communications. (Mimics)
• Zhang, X. et al. (2018) MYC is downregulated by a mitochondrial checkpoint mechanism. Oncotarget. (Inhibitors)
• Jones Ofori et al. (2017) Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell. Scientific Reports. (Inhibitors)

Resources:

miRCURY LNA miRNA Detection Probes Custom miRCURY LNA miRNA Detection Probes

• miRCURY LNA miRNA Detection Probes Handbook
• Explore the RNA Universe! Poster

miRCURY LNA miRNA ISH Optimization Kits (FFPE)

• miRCURY LNA miRNA ISH Optimization Kits (FFPE) Handbook
• miRCURY LNA miRNA ISH Optimization Kits (FFPE) Product Sheet

Publications:

• Fukuoka, M. et al. (2018) Supplemental treatment for Huntington’s disease with miR-132 that is deficient in Huntington’s disease brain. Molecular Therapy Nucleic Acids.
• Peng, S-Y. et al. (2018) miR‐134 targets PDCD7 to reduce E‐cadherin expression and enhance oral cancer progression. International Journal of Cancer.
• Ottaviani, S. et al. (2018) TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nature Communications.
• Jiajiem T. et al. (2017) Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells. Scientific Reports.

Resources:

• Custom LNA mRNA Detection Probes
• miRCURY LNA miRNA Detection Probes Handbook

Publications:

• Madelaine, R et al. (2018) A screen for deeply conserved non-coding GWAS SNPs uncovers a MIR-9-2 functional mutation associated to retinal vasculature defects in human. Nucleic Acids Research. 

Products:

• Custom LNA Oligonucleotides
• LNA Phosphoramidites

Resources:

• Custom LNA Oligonucleotides Tools and resources

Publications:

• Santolla, M. et al. (2018) miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling. Journal of Experimental & Clinical Cancer Research.
• Zlatev, I. et al. (2018) Reversal of siRNA-mediated gene silencing in vivo. Nature Biotechnology.
• Colineau, L. et al. (2018) c-Myc is a novel leishmania virulence factor by proxy that targets the host miRNA system and is essential for survival in human macrophages. Journal of Biological Chemistry.
• Spasic, A. et al. (2018) Molecular dynamics correctly models the unusual major conformation of the GAGU RNA internal loop and with NMR reveals an unusual minor conformation. RNA.
• De Simone, V. et al. (2017) Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death. Cell Death & Disease.

Publications:

Tian, K. et al. 2018) Single locked nucleic acid-enhanced nanopore genetic discrimination of pathogenic serotypes and cancer driver mutations. ACS Nano.