3248 - What is the difference between sponge, cubic and lamellar phase?

All three are in meso phases, the difference between them is the ratio of aqueous solution to lipid and hence the degree of organization. Any of the in meso phases might yield crystals. During the vapor diffusion experiment, the equilibrium is shifted from the starting phase (e.g.s LCP phase) to the target phase (e.g., lamellar phase). This endpoint of the equilibrium is another experimental variable, just like the protein concentration or the crystallization solution. The good thing about the NeXtal CubicPhase Plates is that a combination of in meso phase crystallization and vapor diffusion is used; hence you can explore the different phases as the water evaporates from the drop.

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