Is the morphology after H&E staining comparable to formalin-fixed samples?
Yes. Comparable morphology was observed in adjacent pieces from a tissue sample fixed either with neutral-buffered formalin or with the PAXgene Tissue System for a variety of human and animal tissue (Gündisch et al., Virchows Arch. 2014 Aug; Kap et al., PLoS ONE 6(11): e27704). Examples are provided in the Tissue Atlas at www.preanalytix.com. PAXgene Tissue treated specimens have a tendency to be more eosinophilic. If an identical staining pattern to formalin-fixed samples is required, the incubation time in eosin should be reduced.