The paradigm of predictive biomarkers of therapeutic responses to drug intervention has dramatically transformed cancer drug development. However, as translational research on cancer drug development rapidly evolves, the ability to confidently and efficiently identify specific oncogenes and tumor suppressors involved in oncogenesis is becoming increasingly difficult. 

This webinar will focus on the translational research applications of the Human Somatic Mutation Database (HSMD)—a somatic database developed by QIAGEN that contains extensive genomic content relevant to solid tumors and hematological malignancies. Available as a web-based application, this expert-curated resource contains content from over 410,000 real-world clinical oncology cases combined with content from the QIAGEN Knowledge Base, providing gene-level, alteration-level, and disease-level information including clinically observed gene and variant frequencies across diseases. Users can easily search and explore mutational characteristics across genes, synthesize key findings from drug labels, clinical trials, and professional guidelines, and receive detailed annotations for each observed variant. In addition, users can interrogate a bibliography of over 170,000 variant-specific PubMed articles and access individual summaries of alteration-type specific information written by Ph.D. scientists.

Attendees will:

  • Learn what content sources power HSMD
  • Understand how to use and apply HSMD for multiple applications, including translational research and pharmaceutical development 
  • Examine a use case of how to use HSMD to accelerate research and development in new cancer drug development programs 
  • Receive a complimentary 5-day trial of HSMD.
About the speaker
Kyle Nilson, Field Software Trainer
QIAGEN Digital Insight
Kyle Nilson, Ph.D. is a sequencing-focused molecular biologist with a background in biochemistry and technical support. As a field software trainer at QIAGEN Digital Insights, Dr. Nilson works closely with QIAGEN’s global bioinformatics team to provide direct customer support and assits with software training, implementation, and optimization. He received his Ph.D. in molecular and cellular biology from the University of Iowa, studying the regulation of RNA polymerase II transcription and co-transcriptional mRNA processing. Dr. Nilson went on to complete his postdoctoral training at Penn State and Cornell University, where he focused exclusively on next-generation sequencing method development to study chromatin.
Iman Bhattacharya, Senior Global Product Marketing Manager
QIAGEN Digital Insights
Iman Bhattacharya is a Senior Global Product Marketing Manager at QIAGEN Digital Insights (QDI), Iman work with the clinical and discovery bioinformatics research team. Prior to joining QDI, he worked as Senior marker development manager to establish demand for NGS testing in the Clinical Oncology market segment in Pan-India, in Premas LifeSciences. Iman has his MS in Computational Biology from the University of Delaware.
Date of recording:Thursday, December 15, 2022
Duration:60 minutes
Next Generation Sequencing