LNA Technology

Detect and discriminate short or closely related sequences with ease

LNA oligos exhibit unprecedented thermal stability when hybridized to their complement. This much higher affinity – compared to traditional DNA or RNA oligos – helps overcome the difficulties of studying very short sequences. LNA oligos have greatly improved, and in many cases enabled, specific and sensitive detection of non-coding RNA and other small RNA molecules. Beyond RNA, these powerful tools are ideal for detecting low-abundance, short or highly similar targets in many other research applications. QIAGEN provides a comprehensive portfolio of LNA-enhanced research tools. Read on and learn how you can use these to gain more insights from your experiments.

The Power of LNA
LNA tools have unprecedented sensitivity and specificity – ideal for challenging applications, in which the target is present at low levels
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Custom LNA Oligonucleotide Design and Applications
Learn how to create custom LNA-enhanced oligos for applications not covered by our standard products
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LNA Application Stories
LNA enhancement enables powerful analyses in many different research applications – see what others are doing
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Gene Expression Analysis
Choose between SYBR Green or an LNA-enhanced hydrolysis probe for detection
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miRNA Quantification
Extremely sensitive and specific miRNA quantification, with a fast and easy workflow – even for samples with low RNA content
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RNA/miRNA Sequencing
Reaction chemistries and simplified workflows for preparing robust NGS libraries and eliminating PCR and sequencing bias
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RNA/miRNA Function Studies
Unique and innovative designs ensure high potency and target specificity to help you discover new RNA functions in vitro and in vivo
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RNA/miRNA Localization
Superior binding affinity enables differentiation of splice variants, isoforms and small mutations with an exceptionally high signal-to-noise ratio
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LNA Resource Center
The unique characteristics of LNA make it a powerful tool, not only for miRNA research but also for detection of low-abundance, short or highly similar targets in a number of applications.
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