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QIAcube Connect

For fully automated, spin-column-based nucleic acid extraction that you can manage from outside the lab using QIAsphere
  • Automates over 80 QIAGEN kits with over 140 standard protocols for DNA, RNA and protein sample processing
  • Optional protocol customization expands the use to over 3000 protocols
  • Get reproducible results with less hands-on time
  • QIAsphere-ready: monitor runs remotely, for quick response times, through the QIAsphere App

QIAcube Connect is redefining the benefits of automated sample processing. Go beyond fully automating your QIAGEN spin-column extraction and purification protocols at the push of a button. QIAcube Connect also lets you monitor and manage your instrument remotely, from your mobile device or desktop computer, by using the QIAsphere App.

Explore the demo tool to learn more about QIAcube Connect.

QIAcube Connect operates in conjunction with QIAcube Connect Accessories.

To find resources for the QIAcube, visit the QIAcube (classic) resource page.

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Cat No./ID: 9002864
QIAcube Connect
Instrument, 1-year warranty on parts and labor

QIAcube Connect is designed to perform fully automated purification of nucleic acids and proteins in molecular biology applications. The system is intended for use by professional users trained in molecular biological techniques and the operation of QIAcube Connect.

Product Details

The QIAcube Connect worktable
The features of the QIAcube Connect worktable, which lets you process up to 12 samples, include: 3 tip/enzyme racks for easy loading, a sample tube holder/shaker, bottle racks for your reagents, a robotic arm with sensors and a UV light for decontamination.
Automated QIAprep Mini standard procedure
Using the QIAcube Connect. Fully automated purification of nucleic acids or proteins using QIAGEN spin kits, such as QIAprep Mini kits, on the QIAcube Connect eliminates the need for tedious manual steps. Sample preparation on the QIAcube Connect follows the same steps as the manual procedure (i.e., lysis, bind, wash and elute). No change in purification chemistry is required.
The QIAcube Connect touchscreen
The QIAcube Connect has a large integrated touchscreen that simplifies protocol selection, and clear on-screen messages guide the user through worktable setup, taking ease-of-use to the next level.
The QIAcube Connect UV light
The QIAcube Connect instrument comes with a built-in UV light source that enables full worktable decontamination, and prevents any sample carryover.

The plug-and-play QIAcube Connect simplifies purification by automating QIAGEN spin-column kits. No change of chemistry is needed, so startup is fast, results are immediate, and performance is comparable to the manual procedure.  


QIAcube Connect includes a centrifuge, heated shaker, pipetting system and robotic gripper (see "The QIAcube Connect worktable"). These let the QIAcube Connect fully automate more than 80 QIAGEN spin column kits. 

UV light decontamination

QIAcube Connect decontaminates your full worktable with built-in UV light (see ''The QIAcube Connect principle'') to prevent carryover between samples (see "Genomic DNA (gDNA) barely detectable after UV light exposure").

Remote connectivity with QIAsphere

QIAcube Connect is QIAsphere-ready. QIAsphere gives full connectivity so you can step out of the lab to ponder on your research while keeping an eye on your instrument run status.

Stay alert to important instrument events with QIAsphere's push notifications. You can even prepare the next run on the go, check maintenance status and manage run reports from anywhere, at anytime. Increase the efficiency and productivity of your lab. Learn more about QIAsphere.

Barcode scanner

Track samples and sample prep kit information throughout the process, using the handheld barcode scanner that comes with the kit.

Illuminated worktable

Light inside the instrument makes it easier for you to load your samples and perform your experiments.

Protocols for various sample types

QIAcube Connect has a variety of pre-installed protocols for purification of RNA, genomic DNA, plasmid DNA, viral nucleic acids and proteins, plus DNA and RNA cleanup. All standard protocols in the expanding range can also be downloaded free of charge. Customized protocols can also be requested.


QIAcube Connect isolates highly pure nucleic acids or proteins using a spin-column-based lyse, bind, wash and elute procedure (see ''Automated QIAprep Mini Standard procedure'').

Unparalleled ease-of-use

A large touchscreen (see figure ''The QIAcube Connect touchscreen'') simplifies protocol selection. Clear on-screen messages guide you through worktable setup. You are unlikely to make mistakes because the labware and accessories fit onto the worktable only in the correct orientation. In addition, a fully automated load check helps to ensure that samples, reagents and labware are loaded correctly.

Dedicated kits for DNA and RNA preps

Dedicated QIAcube Connect kits further simplify automated spin-preps for purification of RNA, genomic DNA and viral RNA. Rotor-adapters that come with the kits are pre-loaded with spin columns and elution tubes, so they are ready to use right out of the box. And then, to lessen the risk of errors even more, tubes required for the manual procedure are not included in kits dedicated for use with QIAcube Connect.


QIAcube Connect is highly suitable for academic research laboratories as well as pharmaceutical, biotechnology, and biomedical research laboratories performing applications, such as:

  • Sequencing/sequencing analysis
  • Gene expression analysis
  • Genotyping
  • Proteomics 
  • Microbiome research

Have your throughput demands increased? Do you want to expand your application range or further streamline workflows? Do you need to manage more complex samples? Do you need improved connectivity?

If the answer to any of these questions is yes, then QIAGEN’s trade-in/trade-up program is just right for you!

QIAGEN makes it easy to keep up to speed with the latest automation and sample processing technologies. Simply exchange an old instrument for a new one. Improve your efficiency by trading in a competitor instrument or trading up with an older QIAGEN instrument.

Learn more about trade-in/trade-up opportunities.


Altitude Up to 2000 m (6500 ft)
Centrifuge 10,640 rpm maximum, 12,000 x g maximum, swing-out rotor maximum 45°, 12 rotor positions
Data output USB stick: USB2.0; Compatible OS: Windows 8, Windows 7, Windows Vista, Windows XP (SP3 or later); Mac OS x 10,1 or later; Operating temperature range: 0ºC to 35ºC; Operating humidity range: 10 to 90% (with no condensation); Storage temperature range: –20ºC to 60ºC (–4ºF to 140ºF); Storage humidity range: 10 to 90% (with no condensation); Formatting: FAT32
Environmental class 3K2 (IEC 60721-3-3)
Instrument dimensions Dimensions (hood closed): width 65 cm (25.6 in.), height 58 cm (22.8 in.), depth 62 cm (24.4 in.); Dimensions (hood open): width 65 cm (25.6 in.), height 86 cm (34 in.), depth 62 cm (24.4 in.); Mass: QIAcube Connect: 71.5 kg (157.6 lb.), Accessories: 3 kg (6.6 lb.)
Operating temperature 18 to 28ºC (64.4 to 82.4ºF)
Pipetting system Syringe size 1 ml, pipetting range 5–900 µl
Place of operation For indoor use only
Pollution level 2
Relative humidity 15–75% (non-condensing)
Shaker Speed 100–2000 rpm, amplitude 2 mm, heating range of ambient temperature to 70°C (158°F), ramp-up time of <5 minutes from ambient temperature to 55°C (±3°C). Difference in the temperature detected by the internal sensor and the temperature of the sample liquid is approximately –2°C.
Software QIAGEN protocols are pre-installed on the QIAcube Connect.
Special feature Handheld scanner; Scan pattern: Area Image (838 x 640-pixel array); Motion tolerance: Up to 610 cm/s (240 in/s) for 13 mil UPC at optimal focus; Symbol contrast: 20% minimum reflectance difference; Decode capability: Reads standard 1D, PDF, 2D, Postal and OCR symbology
Storage conditions Temperature: 15ºC to 30ºC (59ºF to 86ºF) in manufacturer’s package; Relative humidity: Max. 75% (non-condensing); Environmental class: 1K2 (IEC 60721-3-1)
Table capacity Up to 12 samples per run
Technical data Power: 100–240 V AC, 50/60 Hz, 650 VA Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages. Note: The apparent power can exceed 650 VA for up to 2 seconds during the centrifuge acceleration and can reach an approximate value of 1000 VA.; Fuse: 2x T6.3A L 250V; Overvoltage category: II
Touchscreen 10.4” TFT Touchscreen, active area 211.2 x 158.4 mm, resolution 800*600 SVGA
Transportation conditions –25°C to 60°C (–13°F to 140°F) in manufacturer's package; Max. 75% relative humidity (non-condensing); Environmenal class: 2K2 (IEC 60721-3-2)
UV lamp Wavelength: 278nm; Optical power: 200-300mW

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FAQs (19)
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Application Notes (2)

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Extraction of microbiome DNA using the DNeasy PowerSoil Pro Kit manually and automated on the QIAcube Connect and QIAcube
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Instrument Technical Documents (1)
The QIAcube Connect System and 21 CFR Part 11 Regulations
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User-Developed Protocols (1)
This protocol has been adapted to allow the user to replace the epithelial transfer and sperm pellet wash steps with an automated protocol using the QIAcube Connect.
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