Human biomedical research
Unraveling the human microbiome
If it’s on or under your skin, it is worth analyzing! Studying how the gut microbiome affects someone’s mood or metabolic disorders? Are you investigating how resident microbes are affected by cancer and vice versa ? Linking the human microbiome to a research question for insightful results requires a reliable workflow from sample preparation and nucleic acid isolation to sequencing and bioinformatics.
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What is the human microbiome?
The human microbiome is the collection of all the microorganisms (bacteria, archae, fungi, viruses and eukaryotes) that live on and inside the human body. These microbial communities are present in a multitude of different tissues, systems, regions and fluids: e.g. skin, mammary glands, seminal fluid, uterus, ovarian follicles, lung, saliva, oral cavity, conjunctiva, biliary tract, urethra, bladder, vagina and gastrointestinal tract.
What role does the human gut microbiome play in health and disease?
The gut microbiome plays a pivotal role in human health and disease and is essential for human development, immunity and nutrition. Often referred to as the microbiota-gut-brain-axis, the underlying molecular mechanisms that comprise the link between the gut microbiome and its effect on our brain and behaviour are slowly being revealed. The disturbance of the gut microbiome homeostasis has been associated with various pathological conditions, both systemic (obesity, diabetes, cancer and atopy) and gut-related (irritable bowel syndrome IBS, inflammatory bowel disease IBD).