Key publications using Genomic Services

Sequencing services

• Equine arteritis virus long-term persistence is orchestrated by CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis
  Carossino, M., Dini, P., Kalbfleisch, T.S., Loynachan, A.T., Canisso, I.F., Cook, R.F., Timoney, P.J., and Balasuriya, U.B.R. (2019)

• Unraveling the molecular signature of extracellular vesicles from endometrial-derived mesenchymal stem cells: potential modulatory effects and therapeutic applications
  Marinaro, F., Gómez-Serrano, M., Jorge, I., Silla-Castro, J.C., Vázquez, J., Sánchez-Margallo, F.M., Blázquez, R., López, E., Álvarez. V., and Casado, J.G. (2019)

• Effects of cardiac sympathetic neurodegeneration and PPARγ activation on Rhesus macaque whole blood miRNA and mRNA expression profiles.
  Metzger, J.M., Lopez, M.S., Schmidt, J.K., Murphy, M.E., Vemuganti, R., and Emborg M.E. (2020)

• The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene.
  Leonardi, A., Kovalchuk, N., Yin, L., Lauren Endres, L., Sara Evke, S., Nevins, S., Samuel Martin, S., Dedon, P. C., Melendez, J.A., Van Winkle, L., Zhang, Q.-Y., Xinxin Ding, X., and Begley, T.J. (2020)

• Circulating thrifty microRNA is related to insulin sensitivity, adiposity, and energy metabolism in adults with overweight and obesity: the POUNDS Lost trial
  Yoriko Heianza, Qiaochu Xue, Jennifer Rood, George A Bray, Frank M Sacks, Lu Qi (2022)

• Characterization of Extracellular Vesicles in Osteoporotic Patients Compared to Osteopenic and Healthy Controls
  Pepe, J., Rossi, M., Battafarano, G., Vernocchi, P., Conte, F., Marzano, V., Mariani, E., Mortera, S.L., Cipriani, C., Rana, I., Buonuomo, P.S., Bartuli, A., De Martino, V., Pelle, S., Pascucci, L., Toniolo, R.M., Putignani, L., Minisola, S. and Del Fattore, A. (2022)

• Systemic delivery of large-scale manufactured Wharton’s Jelly mesenchymal stem cell-derived extracellular vesicles improves cardiac function after myocardial infarction
  Bellio, M.A., Kanashiro-Takeuchi, R.M., Takeuchi, L., Kulandavelu, S., Lee, Y.S., Balkan, W., Young, K.C., Hare, J.M. and Khan, A. (2022)

• Exploration of extracellular vesicle miRNAs, targeted mRNAs and pathways in prostate cancer: relation to disease status and progression
  Puhka, M., Thierens, L., Nicorici, D., Forsman, T., Mirtti, T., af Hällström, T., Serkkola, E. and Rannikko, A., (2022)

• Extracellular circulating miRNAs as stress-related signature to search and rescue dogs
  Guelfi, G., Iaboni, M., Sansone, A., Capaccia, C., Santoro, M.M. and Diverio, S. (2022)

• Small RNA-Seq Reveals Similar miRNA Transcriptome in Children and Young Adults with T-ALL and Indicates miR-143-3p as Novel Candidate Tumor Suppressor in This Leukemia
  Dawidowska, M., Maćkowska-Maślak, N., Drobna-Śledzińska, M., Kosmalska, M., Jaksik, R., Szymczak, D., Jarmuż-Szymczak, M., Sadowska-Klasa, A., Wojtaszewska, M., Sędek, Ł. and Wróbel, T. (2022)

• Insight into the pulmonary molecular toxicity of heated tobacco products using human bronchial and alveolar mucosa models at air–liquid interface
  Rahman, M., Irmler, M., Introna, M., Beckers, J., Palmberg, L., Johanson, G., Upadhyay, S. and Ganguly, K. (2022)

• An Isogenic Collection of Pluripotent Stem Cell Lines With Elevated α-Synuclein Expression Validated for Neural Induction and Cortical Neuron Differentiation
  Natalwala, A., Behbehani, R., Yapom, R. and Kunath, T. (2022)

• Circulating MicroRNA Profiles as Potential Biomarkers for Differentiated Thyroid Cancer Recurrence
  Jankovic Miljus, J., Guillén-Sacoto, M.A., Makiadi-Alvarado, J., Wert-Lamas, L., Ramirez-Moya, J., Robledo, M., Santisteban, P. and Riesco-Eizaguirre, G. (2022)

• Dendrimer-2PMPA Delays Muscle Function Loss and Denervation in a Murine Model of Amyotrophic Lateral Sclerosis
  Tallon, C., Sharma, A., Zhang, Z., Thomas, A.G., Ng, J., Zhu, X., Donoghue, A., Schulte, M., Joe, T.R., Kambhampati, S.P. and Sharma, R., (2022)

• Circulating miRNAs signature on breast cancer: the MCC-Spain project
  Gómez-Acebo, I., Llorca, J., Alonso-Molero, J., Díaz-Martínez, M., Pérez-Gómez, B., Amiano, P., Belmonte, T., Molina, A.J., Burgui, R., Castaño-Vinyals, G. and Moreno, V. (2023)

• Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial
  Scherbak, N.N., Kruse, R., Nyström, T. and Jendle, J. (2023)

• Controlling Loess Erosion by Bio-Stimulated Microbial Induced Calcite Precipitation
  Tsesarsky, M., Gruber, A., Abramov, K. and Raveh-Amit, H. (2023)

• Dysregulation of MicroRNAs in Adult Osteogenesis Imperfecta: The miROI Study
  Mercier‐Guery, A., Millet, M., Merle, B., Collet, C., Bagouet, F., Borel, O., Sornay‐Rendu, E., Szulc, P., Vignot, E., Gensburger, D. and Fontanges, E., (2023)

• Placental microRNAs relate to early childhood growth trajectories
  Kennedy, E.M., Hermetz, K., Burt, A., Pei, D., Koestler, D.C., Hao, K., Chen, J., Gilbert-Diamond, D., Ramakrishnan, U., Karagas, M.R. and Marsit, C.J. (2023)

• Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature
  Taylor, L., Wade, P.K., Johnson, J.E., Aldighieri, M., Morlando, S., Di Leva, G., Kerr, I.D. and Coyle, B. (2023)

• Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients
  Nuñez-Borque, E., Fernandez-Bravo, S., Rodríguez Del Rio, P., Palacio-García, L., Di Giannatale, A., Di Paolo, V., Galardi, A., Colletti, M., Pascucci, L., Tome-Amat, J. and Cuesta-Herranz, J. (2023)

• Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth
  Tehrani, J.M., Kennedy, E., Tung, P.W., Burt, A., Hermetz, K., Punshon, T., Jackson, B.P., Hao, K., Chen, J., Karagas, M.R. and Koestler, D.C. (2023)

• Mitigation of aeolian erosion of loess soil by Bio-Stimulated microbial induced calcite precipitation
  Raveh-Amit H, Gruber A, Abramov K, Tsesarsky M. (2024)

• Exploring the miRNAs Profile in Dark-Cutting Beef
  González-Blanco, L., Royo, L.J., Diñeiro, Y., García-Torres, S., Coto-Montes, A., Sierra, V. and Oliván, M. (2024)

• Assessment of wood smoke induced pulmonary toxicity in normal- and chronic bronchitis-like bronchial and alveolar lung mucosa models at air–liquid interface
  Upadhyay, S., Rahman, M., Rinaldi, S., Koelmel, J., Lin, E.Z., Mahesh, P.A., Beckers, J., Johanson, G., Pollitt, K.J.G., Palmberg, L. and Irmler, M. (2024)

• Plasma Levels of mir-34a-5p Correlate with Systemic Inflammation and Low Naïve CD4 T Cells in Common Variable Immunodeficiency
  Nyström, S., Hultberg, J., Blixt, E., Nilsdotter-Augustinsson, Å. and Larsson, M. (2024)

• Regnase-2 inhibits glioblastoma cell proliferation
  Sowinska, W., Wawro, M., Kochan, J., Solecka, A., Polak, J., Kwinta, B. and Kasza, A., (2024)

Nucleic acid isolation services

• Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group
  Monument, M.J., Johnson, K.M., McIlvaine, E., Abegglen, L., Watkins, W.S., Jorde, L.B., Womer, R.B., Beeler, N., Monovich, L., Lawlor, E.R., Bridge, J.A., Schiffman, J.D., Krailo, M.K., Randall, R.L., and Lessnick, S.L. (2014)

• Microbiome connections with host metabolism and habitual diet
  Asnicar, F., et al. (2021)

• Microbiome connections with host metabolism and habitual diet. Nature Medicine 27:321. DOI: 10.1038/s41591-020-01183-8
  Francesco, A., et al. (2021)

• Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise
  Taraldsen, M.D., Wiseth, R., Videm, V., Bye, A. and Madssen, E. (2022)

• L1CAM immunocapture generates a unique extracellular vesicle population with a reproducible miRNA fingerprint
  Dunlop, R.A., Banack, S.A. and Cox, P.A. (2023)

• Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation
  Nogal, A., Asnicar, F., Vijay, A., Kouraki, A., Visconti, A., Louca, P., Wong, K., Baleanu, A.F., Giordano, F., Wolf, J. and Hadjigeorgiou, G. (2023)

• Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort
  Bermingham, K.M., Stensrud, S., Asnicar, F., Valdes, A.M., Franks, P.W., Wolf, J., Hadjigeorgiou, G., Davies, R., Spector, T.D., Segata, N. and Berry, S.E. (2023)

• Effects of CTLA-4 Single Nucleotide Polymorphisms on Toxicity of Ipilimumab-Containing Regimens in Patients With Advanced Stage Melanoma
  de Joode K, Mora AR, van Schaik RHN, Zippelius A, van der Veldt A, Gerard CL, Läubli H, Michielin O, von Moos R, Joerger M, Levesque MP, Aeppli S, Mangana J, Mangas C, Trost N, Meyer S, Parvex SL, Mathijssen R, Metaxas Y. (2024)

• Snack quality and snack timing are associated with cardiometabolic blood markers: the ZOE PREDICT study
  Bermingham, K.M., May, A., Asnicar, F., Capdevila, J., Leeming, E.R., Franks, P.W., Valdes, A.M., Wolf, J., Hadjigeorgiou, G., Delahanty, L.M. and Segata, N. (2024)

qPCR and dPCR services

• Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy.
  Lim, T.B., Aliwarga, E., Luu, T.D.A., Li, Y.P., Ng, S.L., Annadoray, L., Sian, S., Ackers-Johnson, M.A., Foo, R.S.-Y. (2019)

• Challenges in Cancer Biomarker Discovery Exemplified by the Identification of Diagnostic MicroRNAs in Prostate Tissues
  Ambrozkiewicz, F., Karczmarski, J., Kulecka, M., Paziewska, A., Cybulska, M., Szymanski, M., Dobruch, J., Antoniewicz, A., Mikula, M. and Ostrowski, J. (2020)

• A prophylactic subcutaneous dose of the anticoagulant tinzaparin does not influence qPCR-based assessment of circulating levels of miRNA in humans
  Nilsson, A., Nerhall, A.M., Vechetti, I., Fornander, L., Wiklund, S., Alkner, B., Schilcher, J. and von Walden, F. (2022)

• Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight
  Doncheva, A.I., Romero, S., Ramirez‐Garrastacho, M., Lee, S., Kolnes, K.J., Tangen, D.S., Olsen, T., Drevon, C.A., Llorente, A., Dalen, K.T. and Hjorth, M. (2022)

• Specific Plasma MicroRNA Signatures Underlying the Clinical Outcomes of Hepatitis E Virus Infection
  Costafreda, M.I., Sauleda, S., Riveiro-Barciela, M., Rico, A., Llorens-Revull, M., Guix, S., Pintó, R.M., Bosch, A., Rodríguez-Frías, F., Rando, A. and Piron, M., (2023)

• Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy
  Sæther, J.C., Vesterbekkmo, E.K., Taraldsen, M.D., Gigante, B., Follestad, T., Røsjø, H.R., Omland, T., Wiseth, R., Madssen, E. and Bye, A., (2023)