QIAseq Multimodal HT Panels

A single day sample to sequencing workflow for simultaneous enrichment and profiling of DNA variants, RNA fusions and gene expression levels from one sample input, as low as 10 ng

S_1001_9_QIAseq_Multimodal_Panel
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QIAseq Multimodal Panel (12)

Cat. No. / ID:  333932

QIAseq Multimodal Panel (12) contains ALL reagents (except indices) sufficient to process 12 samples for multimodal (DNA and RNA) sequencing; fixed small panel for a total of 24 reactions
CHF 3,805.00
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PanelIndex
Panel
Index
Type
Small
High content
Samples
12
96
This product contains substances regulated under REACH (EC 1907/2006 Annex XIV). The use of this product in the EU is permitted subject to an exemption (Article 56(3)). Please refer to the REACH notification and the SDS of this product, both of which can be found in the “Resources” section of this page, for more information.
QIAseq Multimodal HT Panels are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease.
Configure at GeneGlobe
Find or custom design the right target-specific assays and panels to research your biological targets of interest.

Features

  • Complete system to go from total nucleic acids to a sequencing-ready library using a single-day workflow
  • Error correction with Unique Molecular Indices (UMIs) to enhance NGS panel sensitivity
  • Unique Dual Indices (UDIs) to reduce sample index hopping
  • Sample to Insight solution for consolidated targeted DNA and RNA sequencing

Product Details

QIAseq Multimodal HT Panels have been developed for consolidated targeted DNA and RNA enrichment and analyses. Unlike other available approaches, QIAseq Multimodal HT Panels do not require 2 separate workflows for DNA and RNA analysis – saving time and conserving samples that are of limited availability.

Principle

Recent advances in NGS chemistries, platforms, and bioinformatics pipelines are enabling users to efficiently interrogate biological samples for changes in DNA and RNA. Other available approaches, however, require the use of 2 separate workflows to prepare libraries from separate DNA and RNA isolates. Limitations of such approaches include:


•    Large amounts of sample material required for generating sufficient amounts of input DNA and RNA for multiple workflows
•    Added complexity of deriving integrated insights from results of different technical approaches, each with its own innate bias
•    Inefficient use of resources
•    Long turnaround time


To overcome the limitations associated with current approaches, QIAseq Multimodal HT Panels start with total nucleic acids (or DNA + RNA) and prepares UDI-containing, Illumina-compatible targeted DNA and RNA libraries using a single-day, consolidated workflow. In addition, QIAseq Multimodal HT Panels have been designed for use with low-yield and poor-quality biological samples.

Procedure

Workflow of the QIAseq Multimodal HT Panels


The QIAseq Multimodal HT Panel workflow can be used to prepare sequencing-ready libraries in a single day. The library insert size is approximately 150 bp, making the QIAseq Multimodal HT Panels highly compatible with low-quality samples, such as FFPE samples.


Robust detection of DNA and RNA biomarkers


QIAseq Multimodal HT Panels can be used to reliably detect DNA and RNA biomarkers using a consolidated workflow from total nucleic acids. The ability of QIAseq Multimodal HT Panels to simultaneously detect DNA and RNA biomarkers has been benchmarked against two separate workflows (namely, QIAseq Targeted DNA Pro and QIAseq Targeted Fusion XP).

 

Applications

QIAseq Multimodal HT Panels can be used to interrogate different types of biomarkers using a consolidated workflow from total nucleic acids, which can be isolated using dedicated sample isolation protocols that have been developed specifically for the QIAseq Multimodal HT Panels.


From DNA:


•    Single nucleotide variants (SNVs)
•    Insertions and Deletions (InDels)
•    Copy number variants (CNVs)


From RNA:


•    Fusions
•    Exon skipping events
•    Gene expression levels

 

Resources

Brochures & Guides (4)
State-of-the-art technologies to fast-track and streamline NGS workflows
QIAseq Multimodal Analytical Technology
QIAseq Multimodal: The power of one
Supplementary Files (1)
List of gene targets for QIAseq Pan-cancer Multimodal Panel
Safety Data Sheets (1)
Certificates of Analysis (1)