CTNNB1
Full Name: catenin (cadherin-associated protein), beta 1,...
Synonyms: CTNNB, beta-catenin...
SpeciesHuman
Gene ID1499
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Interaction Network
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Pathways containing this gene
29
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CDKs (Cyclin-dependent kinases) are a group of serine/threonine protein kinases activated by binding to a regulatory subunit cyclin. These kinases are key regulators of the eukaryotic cell cycle... Show details
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Colorectal cancer represents a relatively well-characterized tumorigenesis paradigm and colorectal carcinoma is one of the leading causes of cancer-related death. Colorectal cancer results from... Show details
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Colorectal tumors arise as a result of the mutational activation of oncogenes coupled with the mutational inactivation of tumor suppressor genes without a major role for gene amplification or... Show details
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EGF (Epidermal Growth Factor) is a small 53 amino acid residue protein that is involved in normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and... Show details
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The Eph family forms the largest group of RTKs (Receptor Tyrosine Kinases) comprising 14 members in mammals that play critical roles in diverse biological processes during development as well as... Show details
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In numerous processes that are vital for the development and maintenance of organism function, cells must communicate crucial information to respond appropriately to the changing environment. As... Show details
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Adhesion between neighboring epithelial cells is a crucial and tightly controlled process. The integrity of cell-cell contacts is essential for the regulation of electrolyte absorption and for the... Show details
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Epithelia in multicellular organisms constitute the frontier that separates the individual from the environment. Epithelia are sites of exchange as well as barriers, for the transit of ions and... Show details
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Heart is the first organ to form and function in the Embryo, and all subsequent events in the life of the organism depend on the Hearts ability to match its output with... Show details
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The G12 subfamily of heterotrimeric G-Proteins , comprised of the Alpha-subunits G-Alpha12 and G-Alpha13, has been implicated as a signaling component in cellular processes ranging from... Show details
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Sertoli-Germ (Spermatid)-cell interactions affect spermatogenesis at the molecular, cellular and biochemical levels. Germ cell movement within the epithelium is vital because germ cells, if... Show details
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Glioblastoma Multiforme (GBM) is biologically aggressive neoplasms which have an elevated, often aberrant, prolifetraive capacity with a diffuse pattern of brain invasion. It is the most malignant... Show details
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GSK3 (Glycogen Synthase Kinase-3) is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.Identified originally as a regulator of glycogen metabolism,... Show details
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Embryonic stem (ES) cells have the capacity to proliferate indefinitely in culture while maintaining the ability to differentiate to form any of the cells of the body. This unique combination of... Show details
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The ECM (Extracellular Matrix) provides the structural framework for the formation of tissues and organs. The ECM binds to substrate adhesion molecules on the surface of cells and influences... Show details
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An essential step in the life cycle of many important pathogenic bacteria is their ability to invade cells that are normally nonphagocytic. Gaining access to an intracellular niche provides... Show details
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Cancer cell genotypes are a manifestation of six essential alterations in cell physiology that collectively dictate malignant growth; self-sufficiency in growth signals, insensitivity to... Show details
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Epithelial continuity depends on a family of small, yet abundant, secreted proteins the TFFs (Trefoil Factors). TFFs are considered as Rapid Response agents to mucosal injury; with up-regulation... Show details
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ESCs (Embryonic stem cells) are Pluripotent cells derived from the ICM (Inner Cell Mass) of Blastocyst-stage embryos. These cells have two distinctive properties: an unlimited capacity for... Show details
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The PI3K (Phosphatidylinositde-3-Kinase) family of enzymes regulate diverse biological functions in every cell type by generating lipid second messengers that ultimately results in the mediation... Show details
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PKA (Protein Kinase-A) is an enzyme that regulates processes as diverse as growth, development, memory, and metabolism. In its inactivated state, PKA exists as a tetrameric complex of two... Show details
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Polyamines are vital for the growth and function of normal cells. The complexity of polyamine metabolism and the multitude of compensatory mechanisms that are invoked to maintain polyamine... Show details
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Presenilins are polytopic transmembrane proteins, mutations in which are associated with the occurrence of Early-onset familial Alzheimers disease, a rare form of the disease that results from a... Show details
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Reelin is a large extracellular glycoprotein involved in the development of architectonic patterns, particularly in the cerebral cortex and hippocampus, where primarily Cajal-Retzius cells... Show details
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The intercellular Adherens Junctions (AJs) are specialized sub-apical structures that function as principle mediators of cell-cell adhesion. Their disassembly correlates with a loss of cell-cell... Show details
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The Blood-Testes Barrier (abbreviated as BTB) acts as a physical barrier between the blood vessels and the seminiferous tubules of the testes. This barrier is formed by tight and adherens... Show details
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Gap Junction (GJ) channels span two plasma membranes and are formed by the alignment of two hemichannels, each consisting of an oligomer of structural subunit proteins, called Cxs (Connexins).... Show details
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The migratory properties of leukocytes or WBCs (White Blood Cells) are indispensable to drive immune responses throughout the body. Leukocytes fall under two categories according to their... Show details
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The development of tissues and organs in multicellular organisms is controlled by the interplay of several signaling pathways that cross talk to provide positional information and induce cell fate... Show details
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