KRAS
Full Name: Kirsten rat sarcoma viral oncogene homolog
Synonyms: c-K-ras2 protein...
SpeciesHuman
Gene ID3845
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Product(s)
Summary
Interaction Network
Pathways
 
 
Available Products
1
Product Product no. Cat. no. List price:
(ENSG00000133703)
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978746 PM00158928 $86.50
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)20A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)19A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)18A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)17A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)16A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)15A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)14A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)13A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)12A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)11A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)10A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)09A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)08A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)07A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)06A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)05A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)04A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)03A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)02A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(-)01A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(+)01A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(+)02A
$231.00
ChIP qPCR Primer Assay
show details
334001 GPH1017031
(+)03A
$231.00
ChIP qPCR Primer Assay
show details
334001 GPH1017031
(+)04A
$231.00
ChIP qPCR Primer Assay
show details
334001 GPH1017031
(+)05A
$231.00
ChIP qPCR Primer Assay
show details
334001 GPH1017031
(+)06A
$231.00
ChIP qPCR Primer Assay
show details
334001 GPH1017031
(+)07A
$231.00
ChIP qPCR Primer Assay
show details
334001 GPH1017031
(+)08A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(+)09A
$231.00
ChIP qPCR Primer Assay
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334001 GPH1017031
(+)10A
$231.00
EpiTect ChIP qPCR Array - Pathway
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334211 GH-507A varies
EpiTect ChIP qPCR Array - Pathway
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334211 GH-502A varies
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Pathways containing this gene
121
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The 14-3-3 proteins are a family of conserved adaptor and scaffolding proteins expressed in all eukaryotic cells. It has evolved from a brain-specific protein to a family of ubiquitously expressed... Show details
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cAMP (Cyclic 3, 5-Adenosine Monophosphate)-dependent Protein Kinase, commonly known as PKA (Protein Kinase-A), is a second messenger-dependent enzyme that has been implicated in a wide range of... Show details
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PKA (Protein Kinase-A) is a second messenger-dependent enzyme that has been implicated in a wide range of cellular processes, including transcription, metabolism, cell cycle progression and... Show details
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The vertebrate neuromuscular junction (NMJ) remains the best-studied model for understanding the mechanisms involved in synaptogenesis, due to its relatively large size, its simplicity of... Show details
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Akt is an evolutionarily conserved serine/threonine kinase involved in a wide variety of cellular functions, including proliferation, cell survival, differentiation, glucose mobilization,... Show details
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Sodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal nephron and colon is the major factor determining total body Na+ levels, and thus, long term blood... Show details
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ADRs (Adrenergic Receptors) are expressed on virtually every cell type in the body and are the receptors for Adrenaline, Epinephrine and Norepinephrine within the Sympathetic Nervous System. They... Show details
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Oxidative stress/Hypoxia is induced by a wide range of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), oxygen shortage, etc. Generation of ROS (Reactive... Show details
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Somatostatin is a widely distributed peptide hormone that plays an important inhibitory role in several biological processes, including neurotransmission, exocrine and endocrine secretions, and... Show details
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The BCR (B-Cell antigen Receptor) plays a critical role in development, survival, and activation of B cells. The BCR is composed of mIg molecules (Membrane Immunoglobulin) and associated... Show details
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Neurotrophins are required for the development and maintenance of the nervous system. The neurotrophin family consists of NGF (Nerve Growth Factor), BDNF (Brain Derived Neurotrophic Factor), NT3... Show details
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The rate and strength of beating of the heart is under the reciprocal control of the Adrenergic (sympathetic) and Cholinergic (parasympathetic) systems. Increased strength (inotropy) in cardiac... Show details
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Stmn1 (Stathmin-1) also referred to as Op18 (Oncoprotein-18) is a major regulator of microtubule dynamics. It is an evolutionarily well conserved 17 kDa cytoplasmic phosphoprotein that is highly... Show details
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Metastatic tumor progression, the process by which tumor cells disseminate from their primary site of development, is dependent upon the disruption of both cell-cell and cell-matrix adhesions.... Show details
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cAMP (Cyclic Adenosine 3,5-monophosphate) is the first identified second messenger, which has a fundamental role in the cellular response to many extracellular stimuli. The cAMP signaling pathway... Show details
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Multicellular organisms have developed highly efficient mechanisms of cell communication to integrate and coordinate the function and proliferation of individual cell types. Gastrointestinal... Show details
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Human eosinophils are crucial effector cells implicated in a number of chronic inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases, and parasitic infections... Show details
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CDKs (Cyclin-dependent kinases) are a group of serine/threonine protein kinases activated by binding to a regulatory subunit cyclin. These kinases are key regulators of the eukaryotic cell cycle... Show details
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The SM (Sphingomyelin) pathway is an evolutionarily conserved stress response system linking diverse environmental stresses (Ultraviolet, Heat Shock, Oxidative Stress, and Ionizing Radiation) to... Show details
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Chemokines, or chemotactic cytokines, are a large family of small (6-14 kDa), structurally related proteins that mediate a wide range of biological activities. As a part of normal immune system... Show details
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Many proto-oncogenes participate in the regulation of apoptosis and closely intertwined with their actions are various growth factors and other genes that participate in the control of cellular... Show details
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CNTF (Ciliary Neurotrophic Factor) is a protein expressed in glial cells, which stimulates gene expression and cell survival and differentiation in a variety of neuronal cell populations and... Show details
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Colorectal cancer represents a relatively well-characterized tumorigenesis paradigm and colorectal carcinoma is one of the leading causes of cancer-related death. Colorectal cancer results from... Show details
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The Chemokine receptor CXCR4 is a 352 amino acid rhodopsin-like GPCR and selectively binds the CXC chemokine Stromal Cell-Derived Factor 1 (SDF-1) also known as CXCL12. This receptor has been... Show details
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Colorectal tumors arise as a result of the mutational activation of oncogenes coupled with the mutational inactivation of tumor suppressor genes without a major role for gene amplification or... Show details
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EGF (Epidermal Growth Factor) is a small 53 amino acid residue protein that is involved in normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and... Show details
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Protein synthesis in eukaryotic organisms is a complex process that requires cooperation among a large number of polypeptides including ribosomal proteins, modification of enzymes, and... Show details
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Cardiac hypertrophy describes an abnormal condition where the heart becomes enlarged. Several factors, such as increased mechanical loading and neuro-hormonal chemicals can induce hypertrophy. ET1... Show details
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Adhesion between neighboring epithelial cells is a crucial and tightly controlled process. The integrity of cell-cell contacts is essential for the regulation of electrolyte absorption and for the... Show details
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Epithelia in multicellular organisms constitute the frontier that separates the individual from the environment. Epithelia are sites of exchange as well as barriers, for the transit of ions and... Show details
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The ErbB (Erythroblastic Leukemia Viral Oncogene Homolog) or EGF (Epidermal Growth Factor) family of transmembrane PTKs (Receptor Tyrosine Kinases) plays an important role during the growth and... Show details
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The ErbB tyrosine kinases (epidermal growth factor receptor (EGFR), ErbB2/HER2, ErbB3, and ErbB4) are cell surface growth factor receptors widely expressed in many developing mammalian tissues,... Show details
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The ErbB receptor tyrosine kinases comprise the four members, epidermal growth factor receptor (EGFR)/ErbB1, Her2/ErbB2, ErbB3 and ErbB4. ErbB-family members are known to play critical roles in... Show details
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The MAPK (Mitogen-Activated Protein Kinase) pathway is one of the primordial signaling systems that nature has used in several permutations to accomplish an amazing variety of tasks. It exists in... Show details
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ERK5 (also known as the BMK1(Big MAP Kinase-1)) is an atypical MAPK that can be activated in vivo by a variety of stimuli, including Serum, Growth factors including EGF (Epidermal Growth Factor),... Show details
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Erythropoiesis is a major pathway for Erythrocyte production, by which pluripotent Hematopoietic Stem Cells give rise to mature end stage cells via a series of... Show details
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Estrogens play important roles in growth, development, reproduction, and maintenance of a diverse range of mammalian tissues. The physiological effects of estrogens are mediated by the... Show details
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Engagement of integrin receptors with extracellular ligands gives rise to the formation of complex multi-protein structures that link the ECM (Extracellular Matrix) to the cytoplasmic Actin ... Show details
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The formation of antigen-antibody complexes plays a fundamental role in our immune defense system. Interaction of these complexes with many cells of the immune system results in a variety of... Show details
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The Fc-GammaR (Fc-Gamma Receptors/Immunoglobulin-Gamma Fc Receptors) expressed on hematopoietic cells play a key role in immune defenses by linking humoral and cellular immunity.Fc-GammaR ... Show details
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The ability of the immune system to respond appropriately to foreign antigen is dependent on a delicate balance of activating and inhibitory signals. Although positive signaling is essential for... Show details
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Angiogenesis, the growth of new blood vessels, plays a key role in many physiological and pathological processes, such as ovulation, embryogenesis, wound repair, inflammation, malignant tumor... Show details
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FLT3 (Fms-like Tyrosine Kinase-3), also known as FLK2 (Fetal Liver Kinase-2) and STK1 (human Stem Cell Kinase-1) was originally isolated as a hematopoietic progenitor cell-specific kinase, and... Show details
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Neutrophils play an important role in the host defense by invading microbial pathogens. Upon infection neutrophils become activated through interaction with chemo attractants and cytokines. These... Show details
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The G12 subfamily of heterotrimeric G-Proteins , comprised of the Alpha-subunits G-Alpha12 and G-Alpha13, has been implicated as a signaling component in cellular processes ranging from... Show details
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The heterotrimeric G-Proteins (Guanine nucleotide-binding Proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine... Show details
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GPCR (G-Protein-Coupled Receptors) constitute a large and diverse family of proteins whose primary function is to transduce extracellular stimuli into intracellular signals. They are among the... Show details
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G-proteins (Guanine Nucleotide-Binding Proteins) are heterotrimeric proteins that mediate signal transduction between many membrane-bound receptors and intracellular effectors. Traditionally,... Show details
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Neurotrophic factors are a broad set of peptide growth factors that tightly regulate many critical aspects of the ontogeny of neurons, such as the number of neurons in a given population, neurite... Show details
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Sertoli-Germ (Spermatid)-cell interactions affect spermatogenesis at the molecular, cellular and biochemical levels. Germ cell movement within the epithelium is vital because germ cells, if... Show details
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Glioblastoma Multiforme (GBM) is biologically aggressive neoplasms which have an elevated, often aberrant, prolifetraive capacity with a diffuse pattern of brain invasion. It is the most malignant... Show details
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Gliomas are the most common intracranial malignant tumors in humans, and high-grade Gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion... Show details
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Normal mammalian sexual maturation and reproductive functions require the integration and precise coordination of hormones at the hypothalamic, pituitary, and gonadal levels. The hypothalamic GnRH... Show details
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GPCRs (Guanine Nucleotide Binding-Protein Coupled Receptors) comprise large and diverse gene families in fungi, plants, and the animal kingdom. Also termed serpentine receptors, GPCRs are... Show details
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GSK3 (Glycogen Synthase Kinase-3) is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.Identified originally as a regulator of glycogen metabolism,... Show details
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HGF (Hepatocyte Growth Factor)/SF (Scatter Factor) is a mesenchymal- or stromal-derived multipotent heparan sulfate-binding and dermatan sulfate-binding pleiotropic polypeptide that mediates... Show details
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The ability of a cell to respond specifically to various external and internal signals plays an essential role in regulating gene expression, differentiation, and cell death. Most often, the... Show details
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Insulin-like growth factor 1 (IGF1) control many biological processes such as cellular metabolism, proliferation, differentiation, and apoptosis. These effects are mediated through ligand... Show details
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IL-2 (Interleukin-2) is a T-Cell-derived cytokine important in the regulation of growth and differentiation of T-Cells, B-Cells, natural killer cells, glioma cells, and cells of the monocyte... Show details
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IL-3 (Interleukin-3) is a cytokine that regulates haemopoiesis, the formation of blood cells in the body. IL-3, also called multi-CSF (multi-lineage colony stimulating factor), is produced by T... Show details
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IL-4 (Interleukin-4) is a T-Cell derived multifunctional cytokine with a molecular weight of approximately 15 to 19 kD that plays a critical role in the regulation of immune responses. It plays an... Show details
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IL-6 (Interleukin-6) is a cytokine that provokes a broad range of cellular and physiological responses, including the immune response, inflammation, hematopoiesis, and oncogenesis by regulating... Show details
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Insulin is the major hormone controlling critical energy functions such as glucose and lipid metabolism. Insulin elicits a diverse array of biological responses by binding to its specific receptor... Show details
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Adhesive interactions between cells and ECM (Extracellular Matrix) proteins play a vital role in biological processes, including cell survival, growth, differentiation, migration, inflammatory... Show details
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An essential step in the life cycle of many important pathogenic bacteria is their ability to invade cells that are normally nonphagocytic. Gaining access to an intracellular niche provides... Show details
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Despite tremendous diversities in their expression, cellular activities in virtually all cell types are regulated by common intracellular signaling systems, and calcium is one important ubiquitous... Show details
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Pancreatic ductal adenocarcinoma is the most common pancreatic neoplasm and as its name suggests it arises from ductal epithelial cells of the pancreas. Other subtypes of pancreatic neoplasms... Show details
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Signaling pathways mediating the transduction of information between cells are essential for development, cellular differentiation and homeostasis. Their dysregulation is also frequently... Show details
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MAPKs (Mitogen-Activated Protein Kinases) are Serine-threonine protein Kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell... Show details
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Endotoxin LPS (Lipopolysaccharide) is a component of the outer membrane of Gram-negative bacteria that potently promotes the activation of macrophages and microglia cells, which are important... Show details
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Protein kinases are ubiquitous enzymes that are able to modulate the activities of other proteins by adding phosphate groups to their tyrosine, serine, or threonine amino acids (phosphorylation).... Show details
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Mitogen-activated protein kinase pathways are evolutionarily conserved kinase modules that link extracellular signals to the machinery that controls fundamental cellular processes such as growth,... Show details
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Estrogen contributes to the development of three of the top five cancers of women--those of the breast, uterus, and ovaries--which together account for an estimated 240,000 new cancer cases a year... Show details
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Cancer cell genotypes are a manifestation of six essential alterations in cell physiology that collectively dictate malignant growth; self-sufficiency in growth signals, insensitivity to... Show details
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Most organisms have evolved mechanisms for efficiently transitioning between anabolic and catabolic states, allowing them to survive and grow in environments in which nutrient availability is... Show details
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ESCs (Embryonic stem cells) are Pluripotent cells derived from the ICM (Inner Cell Mass) of Blastocyst-stage embryos. These cells have two distinctive properties: an unlimited capacity for... Show details
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Cardiac failure, one of the largest health care burdens in the United States and other developed countries is often associated with prolonged and maladaptive cardiac hypertrophy, defined as a... Show details
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As viruses evolve under the highly selective pressures of the immune system, they acquire the capacity to target critical steps in the host cell life, hijacking vital cellular functions to promote... Show details
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One of the most fundamental issues in current biology is how to maintain the critical balance between cell survival and death, both during development and in adulthood. Unrestrained cell division... Show details
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PCD (Programmed Cell Death), often referred to as Apoptosis, is a genetically regulated, self-destructive cellular process found in metazoans. It eliminates individual cells when they are no... Show details
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Proinflammatory cytokines are the principal intercellular mediators of the tissue reaction to trauma and infection. Members of IL-6 (Interleukin-6) hematopoietic cytokine family, that include... Show details
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Angiogenesis plays an important role in pathological events such as tumor growth, wound healing, psoriasis, and the ischemic retinopathies that occur in diabetes and sickle cell disease. The main... Show details
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Cellular responses to many external stimuli involve the activation of several types of MAPK (Mitogen-Activated Protein Kinase) signaling pathways. MAPKs are a family of Serine/threonine kinases... Show details
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p70S6K is a protein Ser-Thr kinase that phosphorylates the ribosomal S6 subunit, a component of the 40S subunit of eukaryotic ribosomes. It plays a role in protein synthesis and in cell growth... Show details
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PAKs (p21-Activated Protein Kinases) are a growing family of serine/threonine protein kinases, which are activated in response to extracellular signals and regulate cell shape and motility. PAKs... Show details
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Pancreatic carcinoma is one of the most enigmatic and aggressive malignant diseases. Neoplasms of the pancreas encompass a wide spectrum of benign and malignant tumors. Pancreatic adenocarcinoma,... Show details
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Signals that derive from cell adhesion to the ECM (Extracellular Matrix) regulate important physiological events including cell motility and growth, and most often involve changes in the... Show details
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Directed cell migration is a critical feature of several physiological and pathological processes, including development, wound healing, atherosclerosis, immunity, angiogenesis, and metastasis.... Show details
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Blood vessel growth and stability are under the exquisite control of a network of pro- and anti-angiogenic factors. Disruption of the balance between these factors is a characteristic of tumor... Show details
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Inositol lipid-specific PLC (Phospholipase-C) isozymes are key signaling proteins in the cellular action of many hormones, neurotransmitters, growth factors, and other extracellular stimuli. PLC... Show details
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The PI3K (Phosphatidylinositde-3-Kinase) family of enzymes regulate diverse biological functions in every cell type by generating lipid second messengers that ultimately results in the mediation... Show details
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PI3Ks (Phosphoinositide-3-Kinases) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration and metabolism. In the immune system, impaired... Show details
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An effective immune response depends on the ability of specialized immunocytes to identify foreign molecules and respond by differentiation into mature effector cells. A cell-surface antigen... Show details
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Polyamines are vital for the growth and function of normal cells. The complexity of polyamine metabolism and the multitude of compensatory mechanisms that are invoked to maintain polyamine... Show details
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Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPARs (Peroxisome Proliferator-Activated Receptors) are ligand-inducible... Show details
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Prl (Prolactin), a multifunctional hormone secreted by the anterior pituitary gland and to a lesser extent by numerous extrapituitary tissues, affects more physiological processes than all other... Show details
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Tumorigenesis is the result of abnormal activation of growth programs in the cells. Most oncogene and tumor suppressor gene products are components of signal transduction pathways that control... Show details
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To achieve strong adhesion to their neighbors and sustain stress and tension, epithelial cells develop many different specialized adhesive structures. Breakdown of these structures occurs during... Show details
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Rap1 (Krev-1/smg p21), a small-molecular weight GTP-binding protein that belongs to the Ras-like superfamily of GTPases, is involved in signal transduction cascades. It is highly homologous to Ras... Show details
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AMLs (Acute Myeloid Leukemias) are characterized with chromosomal translocations resulting in the formation of fusion proteins. Understanding PML (Acute Promyelocytic Leukemia Inducer) function... Show details
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Normal cell function, and its contribution to overall physiology, depends on the proper response of cells to extracellular stimulus. Ras, a legendary cellular and biochemical signaling molecule... Show details
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eIF4 (Eukaryotic Initiation Factor-4) and p70S6K play critical roles in translational regulation. The signaling pathway that regulates p70S6K also regulates the phosphorylation of 4EBP1... Show details
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Proliferation and migration of VSMCs (Vascular Smooth Muscle Cells) in arteries plays an important role in the pathophysiology of atherosclerosis, hypertension, and restenosis after angioplasty. A... Show details
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The Blood-Testes Barrier (abbreviated as BTB) acts as a physical barrier between the blood vessels and the seminiferous tubules of the testes. This barrier is formed by tight and adherens... Show details
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Gap Junction (GJ) channels span two plasma membranes and are formed by the alignment of two hemichannels, each consisting of an oligomer of structural subunit proteins, called Cxs (Connexins).... Show details
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Hypertrophic cardiomyopathy (HCM) is a monogenic cardiac disease with an autosomal dominant pattern of heritability and different penetrance, with a prevalence in the general population of... Show details
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STATs (Signal Transducers and Activators of Transcription) are a family of cytoplasmic proteins with SH2 (Src Homology-2) domains that act as signal messengers and transcription factors and... Show details
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Covalent modifications of proteins, such as phosphorylation, acetylation and ubiquitylation, play an important role in most cellular processes because they can cause rapid changes in the... Show details
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T-Cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-Cell Receptor) is a complex of integral membrane proteins that participates in the activation of... Show details
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The extended growth potential of cancer cells is critically dependent upon the maintenance of functional telomeres, which are specialized chromosomal DNA-protein structures in the terminal regions... Show details
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Cell proliferation in somatic tissues, specification of cell fate during embryogenesis, differentiation and cell death are controlled by a multitude of cell-cell signals and loss of this control... Show details
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Thrombin is a multifunctional serine protease involved in a number of pathophysiological processes that include blood clotting, inflammation, repair processes and tumor metastasis. In brain,... Show details
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Throughout adult life, all blood cells are constantly regenerated from a small pool of hematopoietic stem cells. A single purified stem cell injected into a lethally irradiated host is sufficient... Show details
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TREMs (Triggering Receptor Expressed on Myeloid Cells) are a family of recently discovered receptors of the immunoglobulin superfamily, expressed on various cells of the myeloid lineage, which... Show details
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A recurring theme in neurobiology is the role of a set of molecules that support proliferation, differentiation and survival of neurons. These molecules, collectively referred to as neurotrophins,... Show details
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Proteases are expressed by normal cells in tissue remodeling events and also during pathological events such as tumor invasion and metastasis. Some of the proteases including serine proteinases... Show details
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Solar UV (Ultraviolet) irradiation is the most important environmental carcinogen leading to the development of skin cancers. UV irradiation can cause DNA and protein damage, which in part... Show details
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UV (Ultraviolet) irradiation is a component of sunlight, which has higher energy than visible light. UV radiation (100 and 400 nm) is divided into at least three different categories based on... Show details
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Angiogenesis is important in embryonic development as well as in physiological events and dysregulated angiogenesis is involved in various pathological conditions, like solid tumor growth,... Show details
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VEGF (Vascular Endothelial Growth Factor) is a highly conserved genetic pathway that has evolved from simple to complex systems.The early evolutionary role of VEGF in simple invertebrate systems... Show details
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The formation of blood vessels occurs either by in situ differentiation of endothelial cell precursors (Angioblasts) and association of these cells to form primitive vessels, a process called... Show details
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