TNF
Full Name: tumor necrosis factor
Synonyms: OTTHUMP00000037669...
SpeciesHuman
Gene ID7124
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Product(s)
Summary
Interaction Network
Pathways
 
 
Available Products
1
Product Product no. Cat. no. List price:
RT2 Profiler PCR Array
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330231 PAHS-003Z varies
RT2 Profiler PCR Array
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330231 PAHS-011Z varies
RT2 Profiler PCR Array
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330231 PAHS-012Z varies
RT2 Profiler PCR Array
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330231 PAHS-014Z varies
RT2 Profiler PCR Array
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330231 PAHS-015Z varies
RT2 Profiler PCR Array
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330231 PAHS-017Z varies
RT2 Profiler PCR Array
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330231 PAHS-018Z varies
RT2 Profiler PCR Array
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330231 PAHS-021Z varies
RT2 Profiler PCR Array
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330231 PAHS-022Z varies
RT2 Profiler PCR Array
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330231 PAHS-023Z varies
RT2 Profiler PCR Array
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330231 PAHS-024Z varies
RT2 Profiler PCR Array
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330231 PAHS-025Y varies
RT2 Profiler PCR Array
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330231 PAHS-025Z varies
RT2 Profiler PCR Array
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330231 PAHS-026Z varies
RT2 Profiler PCR Array
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330231 PAHS-027Z varies
RT2 Profiler PCR Array
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330231 PAHS-034Z varies
RT2 Profiler PCR Array
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330231 PAHS-038Z varies
RT2 Profiler PCR Array
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330231 PAHS-051Y varies
RT2 Profiler PCR Array
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330231 PAHS-052Z varies
RT2 Profiler PCR Array
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330231 PAHS-063Z varies
RT2 Profiler PCR Array
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330231 PAHS-066Z varies
RT2 Profiler PCR Array
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330231 PAHS-071Z varies
RT2 Profiler PCR Array
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330231 PAHS-072Z varies
RT2 Profiler PCR Array
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330231 PAHS-073Z varies
RT2 Profiler PCR Array
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330231 PAHS-077Z varies
RT2 Profiler PCR Array
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330231 PAHS-082Z varies
RT2 Profiler PCR Array
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330231 PAHS-084Z varies
RT2 Profiler PCR Array
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330231 PAHS-097Z varies
RT2 Profiler PCR Array
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330231 PAHS-099Z varies
RT2 Profiler PCR Array
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330231 PAHS-120Z varies
RT2 Profiler PCR Array
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330231 PAHS-121Z varies
RT2 Profiler PCR Array
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330231 PAHS-122Z varies
RT2 Profiler PCR Array
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330231 PAHS-125Z varies
RT2 Profiler PCR Array
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330231 PAHS-126Z varies
RT2 Profiler PCR Array
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330231 PAHS-134Z varies
RT2 Profiler PCR Array
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330231 PAHS-139Z varies
RT2 Profiler PCR Array
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330231 PAHS-150Z varies
RT2 Profiler PCR Array
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330231 PAHS-225Z varies
RT2 Profiler PCR Array
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330231 PAHS-147Z varies
RT2 Profiler PCR Array
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330231 PAHS-148Z varies
RT2 Profiler PCR Array
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330231 PAHS-151Z varies
RT2 Profiler PCR Array
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330231 PAHS-212Z varies
RT2 Profiler PCR Array
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330231 PAHS-141Z varies
RT2 Profiler PCR Array
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330231 PAHS-406Z varies
RT2 Profiler PCR Array
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330231 PAHS-502Z varies
RT2 Profiler PCR Array
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330231 PAHS-503Z varies
RT2 Profiler PCR Array
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330231 PAHS-3012Z varies
RT2 Profiler PCR Array
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330231 PAHS-3401Z varies
RT2 Profiler PCR Array
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330231 PAHS-3803Z varies
RT2 Profiler PCR Array
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330231 PAHS-156Z varies
RT2 Profiler PCR Array
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330231 PAHS-157Z varies
RT2 Profiler PCR Array
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330231 PAHS-159Z varies
RT2 Profiler PCR Array
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330231 PAHS-160Z varies
RT2 Profiler PCR Array
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330231 PAHS-162Z varies
RT2 Profiler PCR Array
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330231 PAHS-163Z varies
RT2 Profiler PCR Array
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330231 PAHS-164Z varies
RT2 Profiler PCR Array
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330231 PAHS-160Y varies
RT2 Profiler PCR Array
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330231 PAHS-166Z varies
RT2 Profiler PCR Array
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330231 PAHS-167Z varies
RT2 Profiler PCR Array
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330231 PAHS-154Z varies
RT2 Profiler PCR Array
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330231 PAHS-169Z varies
RT2 Profiler PCR Array
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330231 PAHS-173Z varies
RT2 Profiler PCR Array
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330231 PAHS-181Z varies
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CRHS-00003
Z-100
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CRHS-00011
Z-100
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CRHS-00012
Z-100
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CRHS-00014
Z-100
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CRHS-00015
Z-100
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CRHS-00017
Z-100
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CRHS-00018
Z-100
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CRHS-00021
Z-100
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CRHS-00022
Z-100
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CRHS-00023
Z-100
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CRHS-00024
Z-100
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CRHS-00025
Y-100
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CRHS-00025
Z-100
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CRHS-00026
Z-100
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CRHS-00027
Z-100
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CRHS-00034
Z-100
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CRHS-00038
Z-100
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CRHS-00051
Y-100
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CRHS-00052
Z-100
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CRHS-00063
Z-100
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CRHS-00066
Z-100
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CRHS-00071
Z-100
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CRHS-00072
Z-100
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CRHS-00073
Z-100
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CRHS-00077
Z-100
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CRHS-00082
Z-100
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CRHS-00084
Z-100
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CRHS-00097
Z-100
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CRHS-00099
Z-100
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CRHS-00120
Z-100
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CRHS-00121
Z-100
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CRHS-00122
Z-100
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CRHS-00125
Z-100
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CRHS-00126
Z-100
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CRHS-00134
Z-100
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CRHS-00139
Z-100
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CRHS-00141
Z-100
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CRHS-00147
Z-100
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CRHS-00148
Z-100
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CRHS-00150
Z-100
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CRHS-00151
Z-100
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CRHS-00154
Z-100
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CRHS-00156
Z-100
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CRHS-00157
Z-100
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CRHS-00159
Z-100
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CRHS-00160
Y-100
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CRHS-00160
Z-100
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CRHS-00162
Z-100
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CRHS-00163
Z-100
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CRHS-00164
Z-100
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CRHS-00166
Z-100
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CRHS-00167
Z-100
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CRHS-00169
Z-100
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CRHS-00173
Z-100
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CRHS-00181
Z-100
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CRHS-00212
Z-100
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CRHS-00225
Z-100
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CRHS-00406
Z-100
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CRHS-00502
Z-100
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CRHS-00503
Z-100
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CRHS-03803
Z-100
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(NM_000594)
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330001 PPH00341F $142.00
(NM_000594)
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249900 QT01079561 $92.50
(NM_000594)
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249900 QT00029162 $92.50
(NM_000594)
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QF00062811 varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-071Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-026Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-084Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-097Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-023Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-052Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-017Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-139Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-147Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-014Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-027Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-072Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-151Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-011Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-024Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-066Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-082Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-141Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-018Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-021Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-034Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-063Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-025Y varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-160Y varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-120Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-126Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-015Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-073Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-099Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-148Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-012Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-025Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-038Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-122Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-125Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-022Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-077Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-121Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-003Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-134Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-150Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-159Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-154Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-156Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-051Y varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-157Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-406Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-212Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-502Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-503Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-225Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-160Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-162Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-163Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-164Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-167Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-169Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-166Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-173Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-181Z varies
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Pathways containing this gene
60
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The 14-3-3s are a family of regulatory proteins that is present in all eukaryotes and involved in protein interactions mediating signal transduction pathways. Numerous pathways and processes rely... Show details
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Apoptosis is a physiological process of cell death that plays a critical role in normal development as well as in the pathophysiology of a variety of diseases. The fundamental cellular mechanism... Show details
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The 14-3-3 proteins are a family of conserved adaptor and scaffolding proteins expressed in all eukaryotic cells. It has evolved from a brain-specific protein to a family of ubiquitously expressed... Show details
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Homeostatic trafficking and coordinated infiltration into and within sites of inflammation and infection rely on signaling in response to extracellular cues that in turn controls a variety of... Show details
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Asthma is a highly prevalent disease that involves a complex interplay of environmental factors, airflow obstruction, bronchial hyperresponsiveness, and inflammation. The dominant feature that... Show details
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Akt is an evolutionarily conserved serine/threonine kinase involved in a wide variety of cellular functions, including proliferation, cell survival, differentiation, glucose mobilization,... Show details
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Retinoic Acid, the active form of Vitamin-A (all-trans-Retinol), is a lipophilic molecule, and is known to affect gene transcription. Retinoic Acid is made available in the body through dietary... Show details
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Oxidative stress/Hypoxia is induced by a wide range of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), oxygen shortage, etc. Generation of ROS (Reactive... Show details
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Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animals survival. Certain cells have unique... Show details
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RA (Rheumatoid Arthritis) is a chronic inflammatory disease of unknown etiology affecting diarthrodial joints. Inflammation and hyperplasia of the synovium are the hallmarks of RA. The normal... Show details
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Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also involved in the pathogenesis of many human diseases including human immunodeficiency virus (HIV) infection.... Show details
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Caspases are a family of cysteine proteases that act in concert in a cascade triggered by apoptosis signaling. The culmination of this cascade is the cleavage of a number of proteins in the cell,... Show details
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Apoptosis is a naturally occurring process by which a cell is directed to Programmed Cell Death. Apoptosis is based on a genetic program that is an indispensable part of the development and... Show details
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HBV (Hepatitis-B Virus) belongs to a family of closely related DNA viruses called the Hepadnaviruses. Included in this family are the WHV (Woodchuck Hepatitis Virus), the DHBV (Duck Hepatitis-B... Show details
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HTLV1 (Human T-Lymphotropic Virus-1) is the etiological agent for ATL (Adult T-Cell Leukemia) as well as for TSP (Tropical Spastic Paraparesis) and HAM (HTLV1 Associate Myelopathy). Involvement of... Show details
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The SM (Sphingomyelin) pathway is an evolutionarily conserved stress response system linking diverse environmental stresses (Ultraviolet, Heat Shock, Oxidative Stress, and Ionizing Radiation) to... Show details
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Colorectal cancer represents a relatively well-characterized tumorigenesis paradigm and colorectal carcinoma is one of the leading causes of cancer-related death. Colorectal cancer results from... Show details
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The immune system recognizes the presence of pathogens by several proteins that bind to molecules secreted by the pathogen or carried on their surface. The cells responsible for these immune... Show details
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Cardiac hypertrophy describes an abnormal condition where the heart becomes enlarged. Several factors, such as increased mechanical loading and neuro-hormonal chemicals can induce hypertrophy. ET1... Show details
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Epithelia in multicellular organisms constitute the frontier that separates the individual from the environment. Epithelia are sites of exchange as well as barriers, for the transit of ions and... Show details
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The MAPK (Mitogen-Activated Protein Kinase) pathway is one of the primordial signaling systems that nature has used in several permutations to accomplish an amazing variety of tasks. It exists in... Show details
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Sertoli-Germ (Spermatid)-cell interactions affect spermatogenesis at the molecular, cellular and biochemical levels. Germ cell movement within the epithelium is vital because germ cells, if... Show details
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Leukocyte diapedesis is a chemotactic multistep process that requires optimal chemoattractant presentation by the endothelial barrier. The migration of leukocytes or WBCs (White Blood Cells) from... Show details
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Helicobacter pylori is a gram negative bacterium that causes chronic inflammation in essentially all hosts, a process that increases the risk of developing peptic ulceration, distal gastric... Show details
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The ability of a cell to respond specifically to various external and internal signals plays an essential role in regulating gene expression, differentiation, and cell death. Most often, the... Show details
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IL-10 (Interleukin-10) is a pleiotropic cytokine with important immunoregulatory functions whose actions influence activities of many of the cell-types in the immune system. It is a cytokine with... Show details
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IL-6 (Interleukin-6) is a cytokine that provokes a broad range of cellular and physiological responses, including the immune response, inflammation, hematopoiesis, and oncogenesis by regulating... Show details
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IL-9 (Interleukin-9) is a TH2-type cytokine first described in the mouse as a potent T-Cell and mast cell growth factor. IL-9 has been reported to be a T-Cell derived cytokine with various effects... Show details
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The ECM (Extracellular Matrix) provides the structural framework for the formation of tissues and organs. The ECM binds to substrate adhesion molecules on the surface of cells and influences... Show details
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Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the major cause of morbidity and mortality from CVD (Cardiovascular Disease) in much of the world’s population. The disease... Show details
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Protein kinases are ubiquitous enzymes that are able to modulate the activities of other proteins by adding phosphate groups to their tyrosine, serine, or threonine amino acids (phosphorylation).... Show details
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Mitogen-activated protein kinase pathways are evolutionarily conserved kinase modules that link extracellular signals to the machinery that controls fundamental cellular processes such as growth,... Show details
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Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known Cytokines, enzymes involved in the inflammatory process and of... Show details
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The innate immune response to bacteria is essential for survival but the systemic release of inflammatory mediators results in the life-threatening Septic-shock reaction. Macrophages are essential... Show details
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Cancer cell genotypes are a manifestation of six essential alterations in cell physiology that collectively dictate malignant growth; self-sufficiency in growth signals, insensitivity to... Show details
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One of the basic aspects of the immune response is that the host must be able to clear infections efficiently, while minimizing damage caused to host tissues and regulation of macrophage... Show details
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Survival of an organism is dependent on its ability to rapidly and effectively respond to adverse changes in its environment. Eukaryotic cells possess a number of distinct signal transduction... Show details
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NF-KappaB (Nuclear Factor-KappaB) is a heterodimeric protein composed of different combinations of members of the Rel family of transcription factors. The Rel/ NF-KappaB family of transcription... Show details
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Cellular responses to many external stimuli involve the activation of several types of MAPK (Mitogen-Activated Protein Kinase) signaling pathways. MAPKs are a family of Serine/threonine kinases... Show details
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PAKs (p21-Activated Protein Kinases) are a growing family of serine/threonine protein kinases, which are activated in response to extracellular signals and regulate cell shape and motility. PAKs... Show details
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The gastrointestinal tract represents an important barrier between human hosts and microbial populations. One potential consequence of host-microbial interactions is the development of mucosal... Show details
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Rheumatoid arthritis (RA) is a chronic symmetric polyarticular joint disease that primarily affects the small joints of the hands and feet. The inflammatory process is characterized by... Show details
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Blood vessel growth and stability are under the exquisite control of a network of pro- and anti-angiogenic factors. Disruption of the balance between these factors is a characteristic of tumor... Show details
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The PI3K (Phosphatidylinositde-3-Kinase) family of enzymes regulate diverse biological functions in every cell type by generating lipid second messengers that ultimately results in the mediation... Show details
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Nuclear hormone receptors are transcription factors that bind DNA and regulate transcription in a ligand-dependent manner. PPARs (Peroxisome Proliferator-Activated Receptors) are ligand-inducible... Show details
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AMLs (Acute Myeloid Leukemias) are characterized with chromosomal translocations resulting in the formation of fusion proteins. Understanding PML (Acute Promyelocytic Leukemia Inducer) function... Show details
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Retinoic acid (RA) is a morphogen derived from Retinol (vitamin A) through oxidative reactions mediated by retinol dehydrogenase and retinal dehydrogenase (Ref.1 and 2). Two isomers of RA act as... Show details
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The Rho family of small GTP-binding proteins comprises a group of signaling molecules that are activated by a variety of Growth factors, Cytokines, Adhesion molecules, Hormones, Integrins,... Show details
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The Blood-Testes Barrier (abbreviated as BTB) acts as a physical barrier between the blood vessels and the seminiferous tubules of the testes. This barrier is formed by tight and adherens... Show details
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STATs (Signal Transducers and Activators of Transcription) are a family of cytoplasmic proteins with SH2 (Src Homology-2) domains that act as signal messengers and transcription factors and... Show details
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Covalent modifications of proteins, such as phosphorylation, acetylation and ubiquitylation, play an important role in most cellular processes because they can cause rapid changes in the... Show details
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Nonreceptor PTKs (Protein Tyrosine Kinases) are essential for the development and activation of B-Cells and T-Cells (Ref.1). The Tec kinases represent the second largest family of mammalian... Show details
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During infection, T and B-lymphocytes recognize microbes by means of antigen-specific cell-surface receptors. The humoral immune response is mediated by B cells and the antibodies they produce.... Show details
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TNF (Tumor Necrosis Factor) is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. TNF has been considered as... Show details
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Members of the TNF (Tumor necrosis factor) receptor superfamily play pivotal roles in numerous biological events in metazoan organisms. Ligand-mediated trimerization by corresponding homo- or... Show details
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Various lipid molecules serve as second messengers for transducing signals from the cell surface to the cell interior and trigger specific cellular responses. Recently, several sphingolipids have... Show details
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The Tumor Necrosis Factor Receptor (TNFR) super family represents a growing family, with over 20 members having been identified so far in mammalian cells. TNF-Alpha (Tumor Necrosis Factor-Alpha),... Show details
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TNF (Tumor Necrosis Factor) family members play important roles in various physiological and pathological processes, including cell proliferation, differentiation, apoptosis, modulation of immune... Show details
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The structural and metabolic integrity of bone is maintained through the dynamic process of bone remodeling that results from the coordinate action of bone resorption and the formation of new bone... Show details
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Virus-induced cytokine production and inflammatory cell activation are instrumental in the development of neurogenic inflammatory responses, and these combined factors increase bronchoconstriction... Show details
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