IKBKG
Full Name: inhibitor of kappa light polypeptide gene...
Synonyms: IP, OTTHUMP00000196183, NEMO...
SpeciesHuman
Gene ID8517
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Product(s)
Summary
Interaction Network
Pathways
 
 
Available Products
3
Product Product no. Cat. no. List price:
RT2 Profiler PCR Array
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330231 PAHS-025Y varies
RT2 Profiler PCR Array
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330231 PAHS-025Z varies
RT2 Profiler PCR Array
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330231 PAHS-063Z varies
RT2 Profiler PCR Array
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330231 PAHS-097Z varies
RT2 Profiler PCR Array
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330231 PAHS-141Z varies
RT2 Profiler PCR Array
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330231 PAHS-3012Z varies
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CRHS-00025
Y-100
varies
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CRHS-00025
Z-100
varies
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CRHS-00063
Z-100
varies
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CRHS-00097
Z-100
varies
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CRHS-00141
Z-100
varies
(NM_001099856). RT2 qPCR Primer Assay
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330001 PPH00660A $142.00
(NM_001099856, NM_001099857, NM_003639, XM_005274760, XM_005274761, XM_005274763, XM_005274764, XM_006724853). For 200 x 50 µl reactions or 400 x 25 µl reactions: 10x QuantiTect Primer Assay (lyophilized) supplied in single tube
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249900 QT00009443 $93.40
(NM_001099856, XM_005274760, XM_005274761). For 200 x 50 µl reactions or 400 x 25 µl reactions: 10x QuantiTect Primer Assay (lyophilized) supplied in single tube
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249900 QT01861874 $93.40
(NM_003639). For 200 x 50 µl reactions or 400 x 25 µl reactions: 10x QuantiTect Primer Assay (lyophilized) supplied in single tube
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249900 QT01861888 $93.40
(NM_001099856, NM_001099857, NM_001145255, NM_003639).
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QF00466060 varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-025Y varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
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330241 PBH-025Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-063Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-097Z varies
RT2 Nano PreAMP Primer Mix. For 12 preamplification reactions.
show details
330241 PBH-141Z varies
Configure
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Pathways containing this gene
65
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Apoptosis is a physiological process of cell death that plays a critical role in normal development as well as in the pathophysiology of a variety of diseases. The fundamental cellular mechanism... Show details
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The activation of a naive T-Cell requires two signals: ligation of the TCR (T-Cell Receptor) with the MHC (Major Histocompatibility Complex)/peptide complex on the APC (Antigen Presenting Cell)... Show details
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PKR (Protein Kinase-R) is a 68-kDa serine-threonine kinase that appears to play a primary role in mediating the antiviral activities of infected cells. PKR mediates apoptosis induced by many... Show details
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Akt is an evolutionarily conserved serine/threonine kinase involved in a wide variety of cellular functions, including proliferation, cell survival, differentiation, glucose mobilization,... Show details
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The growth of new blood vessels (angiogenesis) follows a coordinated genetic program of vascular sprouting, vessel assembly, and organotypic maturation. The VEGF/VEGF Receptor and the Notch/Notch... Show details
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Oxidative stress/Hypoxia is induced by a wide range of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), oxygen shortage, etc. Generation of ROS (Reactive... Show details
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Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animals survival. Certain cells have unique... Show details
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Apoptosis, or programmed cell death, is a key event in biologic homeostasis but is also involved in the pathogenesis of many human diseases including human immunodeficiency virus (HIV) infection.... Show details
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The TNF (Tumor Necrosis Factor) and TNF receptor superfamilies (TNFSF and TNFRSF) consist of approximately 50 membrane and soluble proteins that can modulate cellular function. Most of these... Show details
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B cell activating factor of the TNF family (BAFF, also known as TNFSF13B) is a type II transmembrane protein which forms a constitutive trimer. However, it can be readily cleaved by furin to... Show details
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The BCR (B-Cell antigen Receptor) plays a critical role in development, survival, and activation of B cells. The BCR is composed of mIg molecules (Membrane Immunoglobulin) and associated... Show details
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Members of the TNFR (Tumor Necrosis Factor Receptor) superfamily are important for cell growth and survival. CD27 is a member of the TNFR superfamily, which includes TNFR types I and II, NGFR... Show details
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CD28 (Antigen CD28) have been characterized as a co-receptor for the TCR-CD3 (T-Cell Receptor-CD3 Antigen) complex and is responsible for providing the co-stimulatory signal required for T-cell... Show details
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CD40, a TNFR (Tumor Necrosis Factor Receptor) family member, conveys signals regulating diverse cellular responses, ranging from proliferation and differentiation to growth suppression and cell... Show details
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Apoptosis is a naturally occurring process by which a cell is directed to Programmed Cell Death. Apoptosis is based on a genetic program that is an indispensable part of the development and... Show details
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HTLV1 (Human T-Lymphotropic Virus-1) is the etiological agent for ATL (Adult T-Cell Leukemia) as well as for TSP (Tropical Spastic Paraparesis) and HAM (HTLV1 Associate Myelopathy). Involvement of... Show details
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Signal transduction is a common process used by an extensive array of biological ligands to modulate various host cell processes such as growth, differentiation, and proliferation. Cells respond... Show details
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The TNFR (Tumor Necrosis Factor Receptor) superfamily comprises a growing family of type I membrane bound glycoproteins, which interact with the TNF family of soluble mediators and type II... Show details
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EGF (Epidermal Growth Factor) is a small 53 amino acid residue protein that is involved in normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and... Show details
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Estrogens play important roles in growth, development, reproduction, and maintenance of a diverse range of mammalian tissues. The physiological effects of estrogens are mediated by the... Show details
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Fas (also called Apo1 or CD95) is a death domain-containing member of the TNFR (Tumor Necrosis Factor Receptor) superfamily. It has a central role in the physiological regulation of Programmed... Show details
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The G12 subfamily of heterotrimeric G-Proteins , comprised of the Alpha-subunits G-Alpha12 and G-Alpha13, has been implicated as a signaling component in cellular processes ranging from... Show details
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GPCR (G-Protein-Coupled Receptors) constitute a large and diverse family of proteins whose primary function is to transduce extracellular stimuli into intracellular signals. They are among the... Show details
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GITR (Glucocorticoid-Induced TNFR Family-Related) also termed AITR (Activation-Inducible TNFR Family Receptor) is a member of the TNFRSF18 (TNF Receptor Superfamily 18). It is a 228-amino acids... Show details
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GPCRs (Guanine Nucleotide Binding-Protein Coupled Receptors) comprise large and diverse gene families in fungi, plants, and the animal kingdom. Also termed serpentine receptors, GPCRs are... Show details
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Helicobacter pylori is a gram negative bacterium that causes chronic inflammation in essentially all hosts, a process that increases the risk of developing peptic ulceration, distal gastric... Show details
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During immune response, T-cells are optimally activated in secondary lymphoid tissues in order to properly migrate into areas of inflamed tissue. Upon antigen recognition via the... Show details
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Insulin-like growth factor 1 (IGF1) control many biological processes such as cellular metabolism, proliferation, differentiation, and apoptosis. These effects are mediated through ligand... Show details
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IL-1 (Interleukin-1) is a proinflammatory cytokine that stimulates a broad spectrum of immune and inflammatory responses. IL-1 is produced by activated macrophages, endothelia cells, B-Cells, and... Show details
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IL-2 (Interleukin-2) is a T-Cell-derived cytokine important in the regulation of growth and differentiation of T-Cells, B-Cells, natural killer cells, glioma cells, and cells of the monocyte... Show details
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IL-3 (Interleukin-3) is a cytokine that regulates haemopoiesis, the formation of blood cells in the body. IL-3, also called multi-CSF (multi-lineage colony stimulating factor), is produced by T... Show details
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IL-6 (Interleukin-6) is a cytokine that provokes a broad range of cellular and physiological responses, including the immune response, inflammation, hematopoiesis, and oncogenesis by regulating... Show details
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Microorganisms have developed several mechanisms to survive in their hosts environments. These include competition with their hosts for metal acquisition and resistance to host defenses such as NO... Show details
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An essential step in the life cycle of many important pathogenic bacteria is their ability to invade cells that are normally nonphagocytic. Gaining access to an intracellular niche provides... Show details
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Endotoxin LPS (Lipopolysaccharide) is a component of the outer membrane of Gram-negative bacteria that potently promotes the activation of macrophages and microglia cells, which are important... Show details
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Much of the efficiency of the immune system is attributed to the high degree of spatial and temporal organization in the secondary lymphoid organs. Signaling through the LT-BetaR (Lymphotoxin-Beta... Show details
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Protein kinases are ubiquitous enzymes that are able to modulate the activities of other proteins by adding phosphate groups to their tyrosine, serine, or threonine amino acids (phosphorylation).... Show details
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Antigenic stimulation of lymphocytes and other cells of the immune system initiates a complex series of intracellular signal transduction pathways that lead to the expression of a panel of... Show details
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Survival of an organism is dependent on its ability to rapidly and effectively respond to adverse changes in its environment. Eukaryotic cells possess a number of distinct signal transduction... Show details
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The EBV (Epstein-Barr Virus) is a member of the human herpes virus family, which infects greater than 90% of the world’s population. EBV is linked to the development of several malignancies,... Show details
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As viruses evolve under the highly selective pressures of the immune system, they acquire the capacity to target critical steps in the host cell life, hijacking vital cellular functions to promote... Show details
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NF-KappaB (Nuclear Factor-KappaB) is a heterodimeric protein composed of different combinations of members of the Rel family of transcription factors. The Rel/ NF-KappaB family of transcription... Show details
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One of the most fundamental issues in current biology is how to maintain the critical balance between cell survival and death, both during development and in adulthood. Unrestrained cell division... Show details
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The Gram-negative bacterium NTHi (Nontypeable Haemophilus influenzae) is an important human respiratory pathogen in children and adults. In children, it causes OM (Otitis Media), the most common... Show details
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Directed cell migration is a critical feature of several physiological and pathological processes, including development, wound healing, atherosclerosis, immunity, angiogenesis, and metastasis.... Show details
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Blood vessel growth and stability are under the exquisite control of a network of pro- and anti-angiogenic factors. Disruption of the balance between these factors is a characteristic of tumor... Show details
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PI3Ks (Phosphoinositide-3-Kinases) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration and metabolism. In the immune system, impaired... Show details
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An effective immune response depends on the ability of specialized immunocytes to identify foreign molecules and respond by differentiation into mature effector cells. A cell-surface antigen... Show details
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PKR (Protein kinase-R) is a ubiquitously expressed serine-threonine kinase that has been implicated as a signal integrator in translational and transcriptional control pathways. PKR mediates... Show details
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Bone remodeling and homeostasis is an essential function that regulates skeletal integrity throughout adult life in higher vertebrates and mammals. The structural and metabolic integrity of bone... Show details
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TNF (Tumor Necrosis Factor) and TNFR (Tumor Necrosis Factor Receptor) family proteins play important roles in the control of cell death, proliferation, autoimmunity, the function of immune cells,... Show details
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Proliferation and migration of VSMCs (Vascular Smooth Muscle Cells) in arteries plays an important role in the pathophysiology of atherosclerosis, hypertension, and restenosis after angioplasty. A... Show details
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Covalent modifications of proteins, such as phosphorylation, acetylation and ubiquitylation, play an important role in most cellular processes because they can cause rapid changes in the... Show details
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T-Cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-Cell Receptor) is a complex of integral membrane proteins that participates in the activation of... Show details
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TNF (Tumor Necrosis Factor) is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. TNF has been considered as... Show details
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Members of the TNF (Tumor necrosis factor) receptor superfamily play pivotal roles in numerous biological events in metazoan organisms. Ligand-mediated trimerization by corresponding homo- or... Show details
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The Tumor Necrosis Factor Receptor (TNFR) super family represents a growing family, with over 20 members having been identified so far in mammalian cells. TNF-Alpha (Tumor Necrosis Factor-Alpha),... Show details
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TNF (Tumor Necrosis Factor) family members play important roles in various physiological and pathological processes, including cell proliferation, differentiation, apoptosis, modulation of immune... Show details
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During inflammation, which results from tissue injury, infection, or autoimmune diseases, such as RA (Rheumatoid Arthritis), cells release inflammatory mediators that give rise to the symptoms of... Show details
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TLRs (Toll-like receptors) are transmembrane proteins expressed by cells of the innate immune system, which recognize invading microbes and activate signaling pathways that launch immune and... Show details
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The structural and metabolic integrity of bone is maintained through the dynamic process of bone remodeling that results from the coordinate action of bone resorption and the formation of new bone... Show details
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TRAIL (TNF-Related Apoptosis-Inducing Ligand) is a protein consisting of 281 amino acids. It is also called Apo2L. Five proteins, TRAILR1 (DR4), TRAILR2 (DR5/ TRICK2 or KILLER), TRAILR3 (DcR1/... Show details
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TREMs (Triggering Receptor Expressed on Myeloid Cells) are a family of recently discovered receptors of the immunoglobulin superfamily, expressed on various cells of the myeloid lineage, which... Show details
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TWEAK is a cell surface-associated type II transmembrane protein (249-amino acid) belonging to the TNF (Tumor Necrosis Factor) superfamily. The protein was named TWEAK for its relatedness to TNF... Show details
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Yersinia pestis, a gram-negative bacillus, which is responsible for causing bubonic plague, is considered by the Center for Disease Control to be one of the top 5 bioterrorist agents. After... Show details
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