Virtual Demo
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QIAsprint Connect
Cat no. / ID. 9001234
Benchtop instrument for automated magnetic particle based nucleic acid purification from up to 2x96 samples in parallel using QIAsprint extraction chemistry; includes required instrument accessories, and 1-year warranty on parts and labor.
Product TypeKit
QIAsprint Connect
QIAsprint Consumables
Accessories
Services
For Research Use Only. Not for use in diagnostic procedures.
Virtual Demo
Explore the virtual tour to learn more and see this product in action.
Features
- Process up to192 samples of DNA/RNA per run to meet the demands of high-throughput labs
- Purify DNA/RNA even from complex matrices such as stool, soil and plant material
- Customize protocols for specialized applications using the modular kit system
- Prevent cross-contamination in sensitive assays with built-in decontamination
- Monitor runs remotely via QIAsphere to maximize walk-away efficiency
- Cut plastic consumable waste by up to 50% compared to standard consumables in the market through our novel thin-walled plates
Product Details
The QIAsprint Connect is a magnetic-bead extraction system designed for automated, high-throughput nucleic acid purification of up to 2 x 96 samples. The system features two plate hotels and integrated heating and cooling capabilities to support efficient lysis and overnight runs. With a compact benchtop footprint that you can visualize through the augmented reality (AR) tool, the instrument can fit seamlessly into high-throughput labs. QIAsprint Connect supports 21 CFR Part 11 compliance, with secure user management, electronic records and full audit traceability.
The instrument runs QIAGEN-validated protocols or user-defined workflows, configurable through an intuitive touchscreen interface. The instrument supports a broad range of sample types – cells, tissue, whole blood, plant material, pathogen and microbiome samples – through a modular kit system designed for flexibility across applications.
QIAsprint Connect also uses a novel consumable design that reduces plastic use by up to 50% and packaging volume by 40% compared to standard consumables based on internal R&D comparisons (see Thin-walled consumables paired with a reusable metal frame). The stackable plate inserts reduce kit box volume, optimizing storage space and improving shipping efficiency (see Stackable prep plates that reduce storage and logistics burden).
The QIAsprint Connect is for Research Use Only (RUO). Not for use in diagnostic procedures.
Principle
QIAsprint Connect uses automated magnetic-bead technology to purify nucleic acids with precision and consistency at high throughput. A magnetic rod, enclosed in a protective prep cover, is lowered into each sample well, capturing magnetic particles bound to nucleic acids and lifting them from the solution (see Working principle of QIAsprint Connect). The particles are then transferred into the next well containing the wash buffer. When the magnet retracts, the particles are released and gently resuspended and mixed through controlled up-and-down movement of the prep cover. This bind, transfer and release sequence is repeated across multiple wells to ensure thorough purification and reliable results.
With an integrated magnetic head containing 96 rods, QIAsprint Connect processes up to 96 samples in parallel, supporting scalable, reproducible nucleic acid purification in demanding lab environments.
Procedure
QIAsprint Connect is designed to keep hands-on time to a minimum. Once samples and consumables are loaded and a protocol is selected, the system takes over – automatically executing the full magnetic-bead purification workflow.
Running a sample on QIAsprint Connect
- Prepare samples and reagents according to the application protocol
- Load samples, reagents and consumables onto the instrument
- Select a protocol on the touchscreen
- Start the run – the system automatically confirms that all plates and modules are correctly positioned, then executes the automated purification steps
- Collect purified nucleic acids, ready for downstream applications
Protocols can be modified or created from scratch to match your specific workflow.
Applications
QIAsprint Connect supports a growing portfolio of validated applications across key biological samples.
| Sample | Starting material | Protocols and features | Downstream applications |
|---|---|---|---|
| DNA | Cell, tissue and swabs | Genomic DNA extraction from common research sample types | NGS, dPCR, qPCR |
| Whole blood | Genomic DNA purification from blood samples | NGS, dPCR, qPCR | |
| Plant material (including inhibitor-rich samples) | Genomic DNA extraction from plant tissues, including challenging samples | NGS, dPCR, qPCR | |
| Plasmid DNA | Bacterial culture and bacterial pellet | Plasmid DNA purification from 1–5 mL pelleted E. coli cultures or directly from 1 mL bacterial cultures | Restriction enzyme digestion, sequencing, ligation, transformation, transfection, PCR, in vitro transcription |
| RNA | Cells and tissue | Total RNA and microRNA purification from cells and tissues | NGS, dPCR, RT-qPCR |
| Microbiome | Stool | Microbial nucleic acid extraction from inhibitor-rich samples, such as stool | NGS dPCR, qPCR, RT-qPCR |
| Pathogens | Viruses and other pathogens | Viral RNA, viral DNA and bacterial DNA purification from plasma and other biofluids | NGS, dPCR, qPCR, RT-qPCR |
QIAsprint Connect modular kit system
The modular kit system works like a set of building blocks. Each workflow is assembled by combining three components: a sample-specific PrepSet, the appropriate Essential Kit and/or any optional Add-on modules. This structure lets you configure exactly the workflow you need – whether you're purifying DNA, RNA, miRNA, viral nucleic acids, plasmid DNA or microbial DNA (see Concept of the modular kit system). Mix and match modules to adapt to new applications, scale throughput and maintain consistent purification performance across all workflows.
| PrepSets | Essential Kits | Add-ons |
|
Sample-specific pretreatment PrepSets provide lysis and pretreatment chemistry optimized for various sample types. PrepSets address differences in complexity and inhibitors to ensure consistent input for automated extraction. |
The automation backbone The Essential Kit drives the automated bind, wash and elute steps using proven magnetic particle technology. One Essential Kit can be paired with multiple Prep Sets, keeping workflows consistent. |
Targeted adaptation when needed Add-ons introduce optional chemistry for specific workflow needs, such as QIApHish for plasmid workflows or DNase treatment for RNA applications. These targeted additions allow protocol adaptation without complicating the core process. |
For even greater flexibility, nearly all buffers and reagents are also available as standalone items to support specialized workflows (see QIAsprint sets and consumables finder). Use the QIAsprint Connect Protocol Guide to find validated protocols and recommended kit combinations for your sample type and application, or access guidance on adapting a protocol.
Services
Protect your instrument with diverse service solutions from QIAGEN. Learn more about a specific service agreement to match your needs.
Supporting data and figures
Working principle of the QIAsprint Connect
The QIAsprint Connect uses magnetic bead technology to isolate nucleic acids. The prep cover is used to mix buffers and beads. Magnetic rods inserted into the prep cover transfer the beads to the next plate, where the next step of the isolation process takes place.
Specifications
| Features | Specifications |
|---|---|
| Applications | Automated nucleic acid purification |
| Features | Magnetic-bead separation, heating and cooling function, UV-LED decontamination, remote connectivity, touchscreen display, run report management, software-guided maintenance |
| Technology | Magnetic-particle technology |
| Throughput | Up to 2 x 96 samples |
| Dimensions | 49 cm (19.3 in.) x 64 cm (25.2 in.) x 74 cm (29.1 in.) |
| Weight | 62 kg (137 lbs) |
| Touchscreen | T10’’ TFT Touchscreen |
| Operating temperature | 15–32°C (59–90°F) |
| Power | 100–240 VAC, 50–60 Hz, 1000 VA (Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages) |
Resources
Brochures and Guides (2)
Operating software (2)
Technical Information (2)
User Manuals (1)
Safety Data Sheets (1)
Certificates of Analysis (1)
FAQ
What needs to be ordered to run the instrument?
Is it possible to automate the QIAsprint chemistry on other platforms?
Can I trade in another instrument for a QIAsprint Connect?
What is the best way to load the plates with buffers?
Will there be pre-filled plates?
Can QIAGEN develop a customized protocol?
Does the QIAsprint do sample tracking?
Can I use other plastics than the QIAsprint Connect plastics on the instrument?