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QIAcube Connect MDx

For fully automated nucleic acid extraction with QIAGEN’s spin-column kits in molecular diagnostic and clinical research applications
  • Automates selected QIAGEN DSP and non-DSP kits and the PAXgene Blood RNA Kit
  • Offers two software environments for specific user needs: IVD mode (for validated IVD applications) or Research mode (for research applications)
  • Automated DNA, RNA and protein sample processing for a large range of clinical sample types
  • Generates standardized results perfectly suited for IVD requirements when used with QIAGEN DSP kits

QIAcube Connect MDx is expanding the benefits of automated sample processing to IVD protocols with advanced digital capabilities, connectivity and full IVD compliance. QIAcube Connect MDx allows research and diagnostic labs to fully automate and track their trusted QIAGEN spin-column extraction and purification protocols – at the push of a button. The dual software environments provide users with application versatility and increased confidence in valuable insights.

As the next generation QIAcube for IVD nucleic acid extraction, QIAcube Connect MDx offers a flexible system with over 150 standard protocols, including several IVD protocols. Users can access the largest and most dynamic range of protocols related to different IVD and research applications, which can be seamlessly integrated with downstream assays.

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Cat No./ID: 9003070
QIAcube Connect MDx

Instrument, 1-year warranty on parts and labor

The QIAcube Connect MDx is designed to perform automated isolation and purification of nucleic acids in molecular diagnostic and/or molecular biology applications. The system is intended for use by professional users, such as technicians and physicians trained in molecular biological techniques and the operation of the QIAcube Connect MDx system.


Product Details

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The QIAcube Connect MDx worktable
The features of the QIAcube Connect MDx worktable, which lets you process up to 12 samples, include: 3 tip/enzyme racks for easy loading, a sample tube holder/shaker, bottle racks for your reagents, a robotic arm with sensors and a UV light for decontamination.
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The QIAcube Connect MDx UV light

The QIAcube Connect MDx was designed to ensure the highest safety standards. The instrument comes with a built-in UV light source that enables worktable decontamination and a barcode reader for sample tracking.

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The QIAcube Connect MDx IVD software environment

The QIAcube Connect MDx has a large integrated touchscreen that simplifies protocol selection and clear on-screen messages that guide the user through worktable setup, taking ease-of-use to the next level. Users can select IVD mode or Research mode at the log in screen before starting their protocol.

Performance

The QIAcube Connect MDx expands the benefits of automated sample prep to all molecular routine diagnostic and clinical research laboratories. The plug-and-play instrument simplifies and streamlines your purification procedures by fully automating the trusted QIAGEN spin-column kits. No change of chemistry is required, assuring fast startup and immediate results in IVD and molecular biology applications. With advanced digital capabilities and full IVD compliance, the innovative QIAcube Connect MDx enables you to use proven QIAGEN spin-column kits, standardize your results and obtain valuable insights for diagnostic and research settings.

Principle

QIAcube Connect MDx enables continued use of trusted QIAGEN spin-column kits and eliminates the need for tedious manual steps. The innovative QIAcube Connect MDx controls integrated components including a centrifuge, heated shaker, pipetting system, UV LED and robotic gripper. This enables the QIAcube Connect MDx to fully automate more than 150 standard protocols, including several IVD protocols. (See "The QIAcube Connect MDx worktable").

The QIAcube starter pack provides everything you need to use your kits on the instrument (i.e., rotor adapters, filter tips and reagent bottles).

 

UV light decontamination

We understand that IVD experiments require the highest safety procedures. With the QIAcube Connect MDx’s UV light decontamination feature, you can achieve convenient and efficient worktable decontamination. This will greatly decrease the likelihood of carryover between samples, allowing a single instrument to purify DNA, RNA, pathogen nucleic acids and proteins from a vast array of sample types. (See "The QIAcube Connect MDx UV light").

 

New IVD software environment

You can now run IVD protocols in addition to MBA protocols on the QIAcube Connect MDx. Simply select which software environment you need before starting your protocol. At the bottom of the touchscreen, the system shows which software mode is in use. The touchscreen will guide you step-by-step through the correct loading of the work deck and selection of the protocol. (See "The QIAcube Connect MDx IVD software environment").

 

Traceability and process control

The QIAcube Connect MDx has improved run reports that show you the important information you need for your experiments, such as kit expiration dates, sample status, sample location and instrument maintenance information. These detailed reports help you track samples and maintain process and quality control to meet stringent IVD requirements.

 

User management

The QIAcube Connect MDx provides managed user access for tracking of use and data protection. You can set up multiple users with two different roles: administrator and operator. Access to both software modes (Research mode and IVD mode) can be selected for an operator, or a restricted access to only one software mode.

Procedure

QIAcube Connect MDx enables purification of nucleic acids or proteins using a simple lysis, bind, wash and elute procedure. Depending on the chosen application, the procedure may be alternated, or steps may not be required. No change in purification chemistry is required for laboratory automation, as you simply continue to use trusted QIAGEN spin-column kits.

 

Unparalleled ease-of-use

The QIAcube Connect MDx takes ease-of-use to a new level. A large integrated touchscreen simplifies protocol selection and clear on-screen messages guide the user through worktable setup. To increase ease-of-use and high process safety, labware and accessories fit onto the worktable only in the correct orientation. In addition, a fully automated load check helps to ensure that samples, reagents and labware are loaded correctly before a run is initiated.

 

QIAGEN kits for IVD and for research applications

The QIAcube Connect MDx is designed to automate selected QIAGEN DSP and non-DSP kits and the PAXgene Blood RNA Kit. Kits are currently available for purification of RNA, genomic DNA and viral RNA. For a selection of non-DSP kits rotor-adapters are supplied with the kits and pre-loaded with spin columns and elution tubes, delivering greater convenience and time saving. Fully automated purification of nucleic acids using QIAGEN spin kits on the QIAcube Connect MDx eliminates the need for tedious manual steps. Sample preparation on the QIAcube Connect MDx follows the same steps as the manual procedure (i.e., lysis, bind, wash and elute). No change in purification chemistry is required.

 

Remote connectivity

With the new QIAcube Connect MDx, you can spend less time preparing your sample prep run and waiting around for your results, and more time thinking about your research! The QIAcube Connect MDx comes with a connectivity package that provides you with status updates on the progress of your run. Furthermore, the QIAcube Connect MDx comes with a barcode scanner. Simply scan the barcode of your sample prep kit, and all the necessary kit information will immediately appear on your screen.

Applications

QIAcube Connect MDx is highly suitable for routine diagnostic labs and clinical research laboratories performing column-based nucleic acid extraction using QIAGEN spin column technology in modular and moderate throughput workflows. QIAcube Connect MDx is also suitable for academic research laboratories as well as pharmaceutical, biotechnology, and biomedical research laboratories performing applications, such as:

·         Infectious disease (or assays for pathogen detection and viral load monitoring)

·         Sequencing/sequencing analysis

·         Genotyping

·         Gene expression analysis

·         Microbiome research

·         And many more…

Services

Have your throughput demands increased? Do you want to expand your application range or further streamline workflows? Do you need to manage more complex samples? Do you need improved connectivity?

If the answer to any of these questions is yes, then QIAGEN’s trade-in/trade-up program is just right for you!

QIAGEN makes it easy to keep up to speed with the latest automation and sample processing technologies. Simply exchange an old instrument for a new one. Improve your efficiency by trading in a competitor instrument or trading up with an older QIAGEN instrument.

Learn more about trade-in/trade-up opportunities.

Service Plans

Cat No./ID: 9245232
QIAcube Connect, IQOQ Service

QIAcube Connect Installation Qualification and Operational Qualification (IQOQ) verifies that instrument is installed and operating according to manufacturer’s specifications. IQ/OQ allows labs to comply with highest quality standards and ensures the accuracy and precision of the instrument. Certificates are issued to facilitate the qualification of the instrument and the operator.

 

Cat No./ID: 9245260
QIAcube Connect, Core Agreement

For the QIAcube Connect, one on-site repair service and one on-site Preventive Maintenance or Inspection Service, including travel, labor and spare parts for a period of one year. Response time of five business days. Includes a 10% discount on additional repair service during the Core Agreement period.

Cat No./ID: 9245209
QIAcube Connect, Premium Agreement
On-site QIAcube Connect instrument repair, including travel, labor and parts, for a period of 1 year. Response time of next business day. Includes 1 Preventive Maintenance or Inspection Service during the Premium Agreement period.
Cat No./ID: 9245211
QIAcube Connect, Installation & Training

This service combines Installation with Applications Training to help customers gain hands-on experience of hardware, software, applications using QIAGEN platforms and facilitates professional qualifications of laboratory staff.

Cat No./ID: 9245208
QIAcube Connect, Full Agreement

On-site QIAcube Connect instrument repair, including travel, labor and parts, for a period of one year. Response time of two business days.

Cat No./ID: 9003072
QIAcube Connect MDx System FUL-3

Instrument and service agreement package: includes installation, application training, Full Agreement for three years with a two business day response time and three inspection service visits.

Cat No./ID: 9003075
QIAcube Connect MDx System PRM-1

Instrument and service agreement package: includes installation, application training, Premium Agreement for 1 year with a next business day response time and 1 inspection service visit.

Cat No./ID: 9003071
QIAcube Connect MDx System FUL-2

Instrument and service agreement package: includes installation, application training, Full Agreement for two years with a two business day response time and two inspection service visits.

Cat No./ID: 9003073
QIAcube Connect MDx System PRV-1

Instrument and service agreement package: includes installation, application training and one preventive maintenance visit. One-year warranty on labor, travel and parts also included.

Cat No./ID: 9003074
QIAcube Connect MDx Device PRV-1

Instrument and service agreement package: includes one inspection service visit. One-year warranty on labor, travel and parts are also included. Does not include installation and training.

Cat No./ID: 9003076
QIAcube Connect MDx System FUL-1
$34,183.00
Configure

Instrument and service agreement package: includes installation, application training, Full Agreement for one year with a two business day response time and one inspection service visit.

The QIAcube Connect MDx is designed to perform automated isolation and purification of nucleic acids in molecular diagnostic and/or molecular biology applications. The system is intended for use by professional users, such as technicians and physicians trained in molecular biological techniques and the operation of the QIAcube Connect MDx system.


Specifications

Features
Specifications
Altitude Up to 2000 m (6500 ft)
Centrifuge 10,640 rpm maximum, 12,000 x g maximum, swing-out rotor maximum 45°, 12 rotor positions
Environmental class 3K20 (IEC 60721-3-3)
Instrument dimensions Dimensions (hood closed): width 65 cm (25.6 in.), height 58 cm (22.8 in.), depth 62 cm (24.4 in.); Dimensions (hood open): width 65 cm (25.6 in.), height 86 cm (34 in.), depth 62 cm (24.4 in.); Mass: QIAcube Connect MDx: 71.5 kg (157.6 lb.), Accessories: 3 kg (6.6 lb.)
Operating temperature 20 to 25ºC (68 to 77ºF)
Pipetting system Syringe size 1 ml, pipetting range 5–900 µl
Place of operation For indoor use only
Pollution level 2
Relative humidity 20–75% (noncondensing)
Shaker Speed 100–2000 rpm, amplitude 2 mm, heating range of ambient temperature to 70°C (158°F), ramp-up time of <5 minutes from ambient temperature to 55°C (±3°C). Difference in the temperature detected by the internal sensor and the temperature of the sample liquid is approximately –2°C.
Software QIAGEN protocols are pre-installed on the QIAcube Connect MDx or can be downloaded in the Resources section below
Storage conditions Temperature: 5ºC to 40ºC (41ºF to 104ºF) in enclosed location; Relative humidity: Max. 75% (non-condensing)
Table capacity Up to 12 samples per run
Technical data Power: 100–240 V AC, 50/60 Hz, 650 VA Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages. Note: The apparent power can exceed 650 VA for up to 2 seconds during the centrifuge acceleration and can reach an approximate value of 1000 VA.; Fuse: 2x T6.3A L 250V; Overvoltage category: II
Touchscreen 10.4” TFT Touchscreen, active area 211.2 x 158.4 mm, resolution 800*600 SVGA
UV lamp Wavelength: 278nm; Optical power: 200-300mW

Product Resources

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