Up to 15% of colorectal cancer cases have mutations in the BRAF gene (1) and of those mutations, V600E accounts for over 99% (2).
The therascreen BRAF V600E RGQ PCR Kit is an FDA-approved companion diagnostic (CDx) test to identify patients with cases of metastatic colorectal cancer (mCRC) that harbor the V600E mutation in the BRAF gene, and for whom treatment with BRAFTOVI (encorafenib) + cetuximab may be appropriate. The test uses DNA extracted from formalin-fixed, paraffin-embedded (FFPE) human colorectal cancer (CRC) tumor tissue.