Recent advances in NGS chemistries, platforms and bioinformatics pipelines are enabling users to efficiently interrogate biological samples for changes in DNA and RNA. Current approaches, however, require the use of 2 separate workflows to prepare libraries from separate DNA and RNA isolates. Limitations of such approaches include:
- Large amounts of sample material required for generating sufficient amounts of input DNA and RNA for multiple workflows
- Added complexity of deriving integrated insights from results of different technical approaches, each with its own innate bias
- Inefficient use of resources
- Long turnaround times
To overcome the limitations associated with current approaches, the QIAseq Pan-cancer Multimodal Panel starts with total nucleic acids (or DNA and RNA) as input, and generates UDI-containing, Illumina-compatible targeted DNA and RNA libraries using a single-day, consolidated workflow. In addition, the QIAseq Pan-cancer Multimodal Panel has been designed for use with low-yield and poor-quality biological samples.