POLE
Full Name: polymerase (DNA directed), epsilon, catalytic...
Synonyms: POLE1...
SpeciesHuman
Gene ID5426
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Product(s)
Summary
Interaction Network
Pathways
 
 
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Pathways containing this gene
5
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The survival of organism depends on the accurate transmission of genetic information from one cell to its daughters. Such faithful transmission requires not only extreme accuracy in replication of... Show details
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The stable propagation of genetic information requires that the entire genome of an organism be faithfully replicated only once in each cell cycle. In eukaryotes, this replication is initiated at... Show details
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Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging agents. Environmental DNA-damaging agents include UV light and ionizing radiation, as well as a variety... Show details
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The major DNA Repair mechanisms take advantage of the facts that DNA is double-stranded and the same information is present in both strands. Consequently, in cases where damage is present in just... Show details
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The inability to repair DNA damage properly leads to various disorders and enhanced rates of tumor development. Mammals respond to chromosomal insults by activating a complex damage response... Show details
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