IL1B
Full Name: interleukin 1, beta
Synonyms: IL-1, IL-1 beta, IL1-BETA, IL1F2...
SpeciesHuman
Gene ID3553
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Product(s)
Summary
Interaction Network
Pathways
 
 
Available Products
6
Product Product no. Cat. no. List price:
4 siRNAs for Entrez gene 3553:
SI03095701 (FlexiTube siRNA)
SI03059966 (FlexiTube siRNA)
SI00012166 (FlexiTube siRNA)
SI00012145 (FlexiTube siRNA)
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1027416 GS3553 $378.00
Predesigned siRNA directed against human IL1B (NM_000576)
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SI00012145 varies
Predesigned siRNA directed against human IL1B (NM_000576)
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SI00012166 varies
Predesigned siRNA directed against human IL1B (NM_000576)
show details
SI03059966 varies
Predesigned siRNA directed against human IL1B (NM_000576)
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SI03095701 varies
Predesigned siRNA directed against human IL1B (NM_000576)
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SI05028786 varies
Predesigned siRNA directed against human IL1B (NM_000576)
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SI05028793 varies
(NM_000576)
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KH00171 varies
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Pathways containing this gene
49
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Apoptosis is a physiological process of cell death that plays a critical role in normal development as well as in the pathophysiology of a variety of diseases. The fundamental cellular mechanism... Show details
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Homeostatic trafficking and coordinated infiltration into and within sites of inflammation and infection rely on signaling in response to extracellular cues that in turn controls a variety of... Show details
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Chronic obstructive pulmonary disease (COPD), a disease manifested by significantly impaired airflow, afflicts ~14.2 million cases in the United States alone with an estimated 63 million people... Show details
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Akt is an evolutionarily conserved serine/threonine kinase involved in a wide variety of cellular functions, including proliferation, cell survival, differentiation, glucose mobilization,... Show details
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Retinoic Acid, the active form of Vitamin-A (all-trans-Retinol), is a lipophilic molecule, and is known to affect gene transcription. Retinoic Acid is made available in the body through dietary... Show details
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Oxidative stress/Hypoxia is induced by a wide range of environmental factors including UV stress, pathogen invasion (hypersensitive reaction), oxygen shortage, etc. Generation of ROS (Reactive... Show details
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Meningitis is an infection and inflammation of the meninges that affects the pia, the arachnoid and the subarachnoid space. It can be caused by growth of bacteria, virus, fungi, or parasites... Show details
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Atherosclerosis, the pathological basis of CAD (Coronary Artery Disease) and Ischemic Stroke, is the commonest cause of death and disability in the western world. Atherosclerosis is a... Show details
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HBV (Hepatitis-B Virus) belongs to a family of closely related DNA viruses called the Hepadnaviruses. Included in this family are the WHV (Woodchuck Hepatitis Virus), the DHBV (Duck Hepatitis-B... Show details
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The immune system recognizes the presence of pathogens by several proteins that bind to molecules secreted by the pathogen or carried on their surface. The cells responsible for these immune... Show details
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The cell membranes do not simply serve as barriers to separate the inside of the cell from the outside or to delineate different intracellular compartments. These membranes also serve as a... Show details
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Cardiac hypertrophy describes an abnormal condition where the heart becomes enlarged. Several factors, such as increased mechanical loading and neuro-hormonal chemicals can induce hypertrophy. ET1... Show details
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The MAPK (Mitogen-Activated Protein Kinase) pathway is one of the primordial signaling systems that nature has used in several permutations to accomplish an amazing variety of tasks. It exists in... Show details
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Our bones get more brittle with increasing age, and to add insult to injury, the most effective therapy for another problem that is associated with getting older, rheumatoid arthritis, often adds... Show details
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Leukocyte diapedesis is a chemotactic multistep process that requires optimal chemoattractant presentation by the endothelial barrier. The migration of leukocytes or WBCs (White Blood Cells) from... Show details
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Helicobacter pylori is a gram negative bacterium that causes chronic inflammation in essentially all hosts, a process that increases the risk of developing peptic ulceration, distal gastric... Show details
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The ability of a cell to respond specifically to various external and internal signals plays an essential role in regulating gene expression, differentiation, and cell death. Most often, the... Show details
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IL-1 (Interleukin-1) is a proinflammatory cytokine that stimulates a broad spectrum of immune and inflammatory responses. IL-1 is produced by activated macrophages, endothelia cells, B-Cells, and... Show details
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IL-10 (Interleukin-10) is a pleiotropic cytokine with important immunoregulatory functions whose actions influence activities of many of the cell-types in the immune system. It is a cytokine with... Show details
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IL-6 (Interleukin-6) is a cytokine that provokes a broad range of cellular and physiological responses, including the immune response, inflammation, hematopoiesis, and oncogenesis by regulating... Show details
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Signaling pathways mediating the transduction of information between cells are essential for development, cellular differentiation and homeostasis. Their dysregulation is also frequently... Show details
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Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the major cause of morbidity and mortality from CVD (Cardiovascular Disease) in much of the world’s population. The disease... Show details
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Protein kinases are ubiquitous enzymes that are able to modulate the activities of other proteins by adding phosphate groups to their tyrosine, serine, or threonine amino acids (phosphorylation).... Show details
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Mitogen-activated protein kinase pathways are evolutionarily conserved kinase modules that link extracellular signals to the machinery that controls fundamental cellular processes such as growth,... Show details
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Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents. They inhibit synthesis of almost all known Cytokines, enzymes involved in the inflammatory process and of... Show details
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The innate immune response to bacteria is essential for survival but the systemic release of inflammatory mediators results in the life-threatening Septic-shock reaction. Macrophages are essential... Show details
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Cancer cell genotypes are a manifestation of six essential alterations in cell physiology that collectively dictate malignant growth; self-sufficiency in growth signals, insensitivity to... Show details
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One of the basic aspects of the immune response is that the host must be able to clear infections efficiently, while minimizing damage caused to host tissues and regulation of macrophage... Show details
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The optimum functioning of the immune system is crucial for human survival. The invading pathogens are encountered by the cells of the immune system, which include T-Cells, B-Cells, macrophages,... Show details
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Survival of an organism is dependent on its ability to rapidly and effectively respond to adverse changes in its environment. Eukaryotic cells possess a number of distinct signal transduction... Show details
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NF-KappaB (Nuclear Factor-KappaB) is a heterodimeric protein composed of different combinations of members of the Rel family of transcription factors. The Rel/ NF-KappaB family of transcription... Show details
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Cellular responses to many external stimuli involve the activation of several types of MAPK (Mitogen-Activated Protein Kinase) signaling pathways. MAPKs are a family of Serine/threonine kinases... Show details
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PAKs (p21-Activated Protein Kinases) are a growing family of serine/threonine protein kinases, which are activated in response to extracellular signals and regulate cell shape and motility. PAKs... Show details
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The gastrointestinal tract represents an important barrier between human hosts and microbial populations. One potential consequence of host-microbial interactions is the development of mucosal... Show details
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Blood vessel growth and stability are under the exquisite control of a network of pro- and anti-angiogenic factors. Disruption of the balance between these factors is a characteristic of tumor... Show details
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PGC1Alpha (Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1-Alpha) is a tissue-specific transcriptional coactivator that enhances the activity of many nuclear receptors and... Show details
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The PI3K (Phosphatidylinositde-3-Kinase) family of enzymes regulate diverse biological functions in every cell type by generating lipid second messengers that ultimately results in the mediation... Show details
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Retinoic acid (RA) is a morphogen derived from Retinol (vitamin A) through oxidative reactions mediated by retinol dehydrogenase and retinal dehydrogenase (Ref.1 and 2). Two isomers of RA act as... Show details
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eIF4 (Eukaryotic Initiation Factor-4) and p70S6K play critical roles in translational regulation. The signaling pathway that regulates p70S6K also regulates the phosphorylation of 4EBP1... Show details
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The Rho family of small GTP-binding proteins comprises a group of signaling molecules that are activated by a variety of Growth factors, Cytokines, Adhesion molecules, Hormones, Integrins,... Show details
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Bacterial pathogens possess highly specialized adaptive processes that enable their penetration of the host intestinal epithelium and cause disease. Once bound to the epithelial surface, bacteria... Show details
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SOCS (Suppressor of Cytokine Signaling) proteins attenuate Cytokine and Tyrosine Kinase receptor signaling pathways (including those that regulate the immune system) by providing a negative... Show details
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STATs (Signal Transducers and Activators of Transcription) are a family of cytoplasmic proteins with SH2 (Src Homology-2) domains that act as signal messengers and transcription factors and... Show details
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Covalent modifications of proteins, such as phosphorylation, acetylation and ubiquitylation, play an important role in most cellular processes because they can cause rapid changes in the... Show details
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Nonreceptor PTKs (Protein Tyrosine Kinases) are essential for the development and activation of B-Cells and T-Cells (Ref.1). The Tec kinases represent the second largest family of mammalian... Show details
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Cell proliferation in somatic tissues, specification of cell fate during embryogenesis, differentiation and cell death are controlled by a multitude of cell-cell signals and loss of this control... Show details
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The structural and metabolic integrity of bone is maintained through the dynamic process of bone remodeling that results from the coordinate action of bone resorption and the formation of new bone... Show details
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TREMs (Triggering Receptor Expressed on Myeloid Cells) are a family of recently discovered receptors of the immunoglobulin superfamily, expressed on various cells of the myeloid lineage, which... Show details
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Virus-induced cytokine production and inflammatory cell activation are instrumental in the development of neurogenic inflammatory responses, and these combined factors increase bronchoconstriction... Show details
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