ITPR1
Full Name: inositol 1,4,5-trisphosphate receptor, type 1
Synonyms: IP3R, spinocerebellar ataxia 16...
SpeciesHuman
Gene ID3708
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Product(s)
Summary
Interaction Network
Pathways
 
 
Available Products
6
Product Product no. Cat. no. List price:
4 siRNAs for Entrez gene 3708:
SI03086307 (FlexiTube siRNA)
SI03034024 (FlexiTube siRNA)
SI00034545 (FlexiTube siRNA)
SI00034531 (FlexiTube siRNA)
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1027416 GS3708 $378.00
Predesigned siRNA directed against human ITPR1 (NM_001099952, NM_001168272, NM_002222)
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SI00034531 varies
Predesigned siRNA directed against human ITPR1 (NM_001099952, NM_001168272, NM_002222)
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SI00034545 varies
Predesigned siRNA directed against human ITPR1 (NM_001099952, NM_001168272, NM_002222)
show details
SI03034024 varies
Predesigned siRNA directed against human ITPR1 (NM_001099952, NM_001168272, NM_002222)
show details
SI03086307 varies
Predesigned siRNA directed against human ITPR1 (NM_001099952, NM_001168272, NM_002222)
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SI05047007 varies
Predesigned siRNA directed against human ITPR1 (NM_001099952, NM_001168272, NM_002222)
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SI05047014 varies
(NM_001099952)
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KH12766 varies
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Pathways containing this gene
50
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cAMP (Cyclic 3, 5-Adenosine Monophosphate)-dependent Protein Kinase, commonly known as PKA (Protein Kinase-A), is a second messenger-dependent enzyme that has been implicated in a wide range of... Show details
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PKA (Protein Kinase-A) is a second messenger-dependent enzyme that has been implicated in a wide range of cellular processes, including transcription, metabolism, cell cycle progression and... Show details
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PKC (Protein Kinase-C) is a cyclic nucleotide-independent enzyme that phosphorylates serine and threonine residues in many target proteins. PKC plays a pivotal role in mediating cellular responses... Show details
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ADRs (Adrenergic Receptors) are expressed on virtually every cell type in the body and are the receptors for Adrenaline, Epinephrine and Norepinephrine within the Sympathetic Nervous System. They... Show details
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The BCR (B-Cell antigen Receptor) plays a critical role in development, survival, and activation of B cells. The BCR is composed of mIg molecules (Membrane Immunoglobulin) and associated... Show details
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Neurotrophins are required for the development and maintenance of the nervous system. The neurotrophin family consists of NGF (Nerve Growth Factor), BDNF (Brain Derived Neurotrophic Factor), NT3... Show details
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Stmn1 (Stathmin-1) also referred to as Op18 (Oncoprotein-18) is a major regulator of microtubule dynamics. It is an evolutionarily well conserved 17 kDa cytoplasmic phosphoprotein that is highly... Show details
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Ca2+ (Calcium) plays a major role in life and death within T-Cells. Elevation of intracellular free Ca2+ is one of the key triggering signals for T-Cell activation by antigen. The binding of... Show details
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cAMP (Cyclic Adenosine 3,5-monophosphate) is the first identified second messenger, which has a fundamental role in the cellular response to many extracellular stimuli. The cAMP signaling pathway... Show details
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Human eosinophils are crucial effector cells implicated in a number of chronic inflammatory reactions, associated with bronchial asthma, allergic-inflammatory diseases, and parasitic infections... Show details
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CD28 (Antigen CD28) have been characterized as a co-receptor for the TCR-CD3 (T-Cell Receptor-CD3 Antigen) complex and is responsible for providing the co-stimulatory signal required for T-cell... Show details
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Erectile Dysfunction commonly known as ED or Impotence, affects a large segment of the male population that results in impaired relaxation of the smooth muscle cells in the corpus cavernosum and... Show details
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The process of consolidating a new memory and the dynamic complexity of information processing within neuronal networks is greatly increased by activity-dependent changes in gene expression... Show details
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CRH (Corticotropin-Releasing Hormone) and related peptides play a major role in coordinating the behavioral, endocrine, cardiovascular, autonomic and immune mechanisms that allow mammals to adapt... Show details
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The Chemokine receptor CXCR4 is a 352 amino acid rhodopsin-like GPCR and selectively binds the CXC chemokine Stromal Cell-Derived Factor 1 (SDF-1) also known as CXCL12. This receptor has been... Show details
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One of the ultimate frontiers for mankind is the elucidation of the function of the mind. Dopaminergic and Glutamergic are two primary neurotransmitter systems in the brain, which are crucially... Show details
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NO (Nitric Oxide) is a short-lived free radical gas involved in diverse physiological and pathological processes. It is produced along with L-Citrulline by the oxidation of L-Arginine and... Show details
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The ErbB tyrosine kinases (epidermal growth factor receptor (EGFR), ErbB2/HER2, ErbB3, and ErbB4) are cell surface growth factor receptors widely expressed in many developing mammalian tissues,... Show details
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The formation of antigen-antibody complexes plays a fundamental role in our immune defense system. Interaction of these complexes with many cells of the immune system results in a variety of... Show details
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The Fc-GammaR (Fc-Gamma Receptors/Immunoglobulin-Gamma Fc Receptors) expressed on hematopoietic cells play a key role in immune defenses by linking humoral and cellular immunity.Fc-GammaR ... Show details
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Angiogenesis, the growth of new blood vessels, plays a key role in many physiological and pathological processes, such as ovulation, embryogenesis, wound repair, inflammation, malignant tumor... Show details
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Neutrophils play an important role in the host defense by invading microbial pathogens. Upon infection neutrophils become activated through interaction with chemo attractants and cytokines. These... Show details
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GPCR (G-Protein-Coupled Receptors) constitute a large and diverse family of proteins whose primary function is to transduce extracellular stimuli into intracellular signals. They are among the... Show details
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Neurotrophic factors are a broad set of peptide growth factors that tightly regulate many critical aspects of the ontogeny of neurons, such as the number of neurons in a given population, neurite... Show details
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GHRH (Growth Hormone-Releasing Hormone) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. GHRH is produced by GHRH cells in... Show details
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Glioblastoma Multiforme (GBM) is biologically aggressive neoplasms which have an elevated, often aberrant, prolifetraive capacity with a diffuse pattern of brain invasion. It is the most malignant... Show details
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Normal mammalian sexual maturation and reproductive functions require the integration and precise coordination of hormones at the hypothalamic, pituitary, and gonadal levels. The hypothalamic GnRH... Show details
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GPCRs (Guanine Nucleotide Binding-Protein Coupled Receptors) comprise large and diverse gene families in fungi, plants, and the animal kingdom. Also termed serpentine receptors, GPCRs are... Show details
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Helicobacter pylori is a gram negative bacterium that causes chronic inflammation in essentially all hosts, a process that increases the risk of developing peptic ulceration, distal gastric... Show details
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Huntingtons disease, also known as Huntington Chorea, is a dominantly inherited Neurodegenerative disorder featuring progressively worsening Chorea, Psychiatric disturbances and Cognitive... Show details
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During immune response, T-cells are optimally activated in secondary lymphoid tissues in order to properly migrate into areas of inflamed tissue. Upon antigen recognition via the... Show details
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Insulin-like growth factor 1 (IGF1) control many biological processes such as cellular metabolism, proliferation, differentiation, and apoptosis. These effects are mediated through ligand... Show details
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Despite tremendous diversities in their expression, cellular activities in virtually all cell types are regulated by common intracellular signaling systems, and calcium is one important ubiquitous... Show details
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IP3 (Inositol 1,4,5-triphosphate), also known as a second messenger, is a molecule that functions to transfer a chemical signal received by the cell, such as from a hormone, neurotransmitters,... Show details
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Development of a proper immune system requires the selection of lymphocytes expressing a useful repertoire of antigen receptors that can respond to foreign or dangerous antigens but not to self.... Show details
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Cardiac failure, one of the largest health care burdens in the United States and other developed countries is often associated with prolonged and maladaptive cardiac hypertrophy, defined as a... Show details
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Antigenic stimulation of lymphocytes and other cells of the immune system initiates a complex series of intracellular signal transduction pathways that lead to the expression of a panel of... Show details
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PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) is a member of the secretin glucagon-VIP (Vasoactive Intestinal Peptide) family of peptides and is widely distributed in the brain and... Show details
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Inositol lipid-specific PLC (Phospholipase-C) isozymes are key signaling proteins in the cellular action of many hormones, neurotransmitters, growth factors, and other extracellular stimuli. PLC... Show details
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PI3Ks (Phosphoinositide-3-Kinases) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration and metabolism. In the immune system, impaired... Show details
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PKA (Protein Kinase-A) is an enzyme that regulates processes as diverse as growth, development, memory, and metabolism. In its inactivated state, PKA exists as a tetrameric complex of two... Show details
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Rap1 (Krev-1/smg p21), a small-molecular weight GTP-binding protein that belongs to the Ras-like superfamily of GTPases, is involved in signal transduction cascades. It is highly homologous to Ras... Show details
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Proliferation and migration of VSMCs (Vascular Smooth Muscle Cells) in arteries plays an important role in the pathophysiology of atherosclerosis, hypertension, and restenosis after angioplasty. A... Show details
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Acute gastroenteritis is among the most common illnesses of humankind, and its associated morbidity and mortality are greatest among those at the extremes of age, children and the elderly. In... Show details
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Gap Junction (GJ) channels span two plasma membranes and are formed by the alignment of two hemichannels, each consisting of an oligomer of structural subunit proteins, called Cxs (Connexins).... Show details
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Sperm cells are equipped with a limited repertoire of behaviors that exclusively subserve their purpose to fertilize eggs (mature ova). When produced in the testis, sperm are immotile; they... Show details
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T-Cells are a subset of lymphocytes that play a large role in the immune response. The TCR (T-Cell Receptor) is a complex of integral membrane proteins that participates in the activation of... Show details
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Thrombin is a multifunctional serine protease involved in a number of pathophysiological processes that include blood clotting, inflammation, repair processes and tumor metastasis. In brain,... Show details
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The migratory properties of leukocytes or WBCs (White Blood Cells) are indispensable to drive immune responses throughout the body. Leukocytes fall under two categories according to their... Show details
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Vitamin-A (all-trans-Retinol) is a vital and essential micronutrient in the human diet and is required for multiple physiological processes, ranging from vision to embryonic development.... Show details
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