Pyrosequencing in Pharmacogenomics Research

This presentation describes examples of the use of Pyrosequencing in pharmacogenomics research. Pharmacogenomics involves the study of genetic determinants in drug response and toxicity. Pyrosequencing is a unique, medium-throughput technology that allows the analysis of most pharmacogenomic DNA variations within one system, icluding SNPs, indels (insertions/deletions), and short repeats. It also enables assessment of RNA allelic imbalance, DNA methylation status, and gene copy number. Pyrosequencing has been used in pharmacogenomics research in many different disease areas, including oncology, cardiology, and rheumatology. As an example, a current focus is the KRAS gene in colorectal cancer.

In this webinar, you learn about:

  • Utilizing Pyrosequencing in pharmacogenomics
  • Different disease areas including oncology, cardiology, and rheumatology
  • Use of Pyrosequencing for analysis of SNPs, DNA methylation status, and gene copy number

Dr. Janelle Hoskins

Dr Hoskins is the Director of the Molecular Genomics Facility, Institute of Pharmacogenomics and Individualized Therapy, at the University of North Carolina, Chapel Hill USA. She has spent several years working in the field of pharmacogenomics. Dr. Hoskins was awarded her PhD at the University of Sydney, Australia, and did her postdoctoral research at the Washington University of St. Louis on the pharmacogenetics of colorectal cancer agents.