
TB testing with QFT-Plus
Comparison of QFT-Plus and TST for TB testing
QFT-Plus (1-3) | TST (2,4) | |||
---|---|---|---|---|
Single visit assay? | YES | Requires only one patient visit | NO | Requires two patient visits |
Sensitivity? | YES | >95% sensitivity – accurately identify TB-infected patients |
NO | 70% sensitivity – more missed diagnoses |
Specificity? (5) | YES | >97% specificity – less unnecessary follow-up and treatment |
NO | Variable; 59% in BCG-vaccinated populations - false positives result in costly follow-up |
Objective results? | YES | Objective and controlled laboratory assay | NO | Subjective measurement of skin induration |
Affected by BCG vaccination? | YES | Unaffected by BCG vaccination | NO | Results affected by BCG vaccination |
Most cost effective? (6,7) | YES | More cost effective than TST in multiple screening situations |
NO | High program costs due to second visits and false positives |
Detect TB infection with confidence
Top 3 reasons to choose QFT-Plus
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Four tubes, one clear resultQFT-Plus requires just 4 ml of whole blood - either 1 ml in each of the 4 QFT-Plus tubes or into a standard heparin tube. Test results are calculated using a lab-based ELISA assay.
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CD8 T cell technologyCD8 T cells have been shown to play an important role in MTB immunity (8–10). QFT-Plus measures the cell-mediated immune response to MTB infection from both CD4 and CD8 T cells.
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Automated testing solutionThe LIAISON® QuantiFERON-TB Gold Plus* solution allows laboratories to easily benefit from an automated and efficient workflow for less hands-on time & improved time to results.
References:
- QuantiFERON-TB Gold Plus (QFT-Plus) ELISA Package Insert. Current QFT-Plus package inserts are available at www.QuantiFERON.com
- Diel, R., Loddenkemper, R., and Nienhaus, A. (2010) Chest 137, 952.
- Harada, N. et al. (2008) J. Infect. 56, 348.
- Tuberculin Purified Protein Derivative (Mantoux) TUBERSOL® Package insert. Sanofi Pasteur Limited. February 2013. R8-2013.
- Pai, M., Zwerling, A., and Menzies, D. (2008) Ann Intern Med 149, 177–184.
- Pareek, M. et al. (2013) Thorax 68, 230.
- Nienhaus A, et al. (2007) Arch. Occup. Environ. Health. 81, 295–300.
- Turner, J. et al. (1996) Immunology 87, 339.
- Brookes, R.H. et al. (2003) Eur. J. Immunol. 33, 3293.
- Stenger, S. et al. (1998) Science 282, 121.
*QuantiFERON-TB Gold Plus Blood Collection Tubes by QIAGEN and LIAISON Analyzer by DiaSorin.
**QIAreach QuantiFERON-TB is intended for high TB-burden countries.
Product claims may differ from country to country based on regulations and approvals. Contact your country representative for further details.
QFT-Plus is an in vitro diagnostic aid for detection of Mycobacterium tuberculosis infection. QFT-Plus is an indirect test for M. tuberculosis infection (including disease) and is intended for use in conjunction with risk assessment, radiography, and other medical and diagnostic evaluations. QFT-Plus Package Inserts, available in multiple languages, as well as up-to-date licensing information and product-specific disclaimers can be found at www.QuantiFERON.com.