TB Products

TB testing with QFT-Plus

What is QFT-Plus?

QuantiFERON-TB Gold Plus (QFT-Plus) is a simple blood test that aids in the detection of Mycobacterium tuberculosis (MTB), the bacteria which causes tuberculosis (TB). It is the simpler, more affordable way to test for TB infection that produces more accurate results than the century-old tuberculin skin test (TST).

Comparison of QFT-Plus and TST for TB testing

		QFT-Plus (1-3)		TST (2,4)
Single visit assay?	YES	Requires only one patient visit	NO	Requires two patient visits
Sensitivity?	YES	>95% sensitivity – accurately identify TB-infected patients	NO	70% sensitivity – more missed diagnoses
Specificity? (5)	YES	>97% specificity – less unnecessary follow-up and treatment	NO	Variable; 59% in BCG-vaccinated populations - false positives result in costly follow-up
Objective results?	YES	Objective and controlled laboratory assay	NO	Subjective measurement of skin induration
Affected by BCG vaccination?	YES	Unaffected by BCG vaccination	NO	Results affected by BCG vaccination
Most cost effective? (6,7)	YES	More cost effective than TST in multiple screening situations	NO	High program costs due to second visits and false positives

Improve your TB testing

Switch from the tuberculin skin test to QFT-Plus for accurate and convenient TB detection.

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Detect TB infection with confidence

Webinar: Is your TB testing up to date?

Evolving policies and recent technological advances in LTBI testing and treatment represent a new evolutionary step in tuberculosis infection control. Recent publications show the potential of QFT-Plus for at-risk patient populations.

In this webinar, Dr. Masae Kawamura provides an overview of the standard policies and latest scientific advancements in TB testing. She also discusses new preventive treatment regimens and the benefits of QFT-Plus.

Watch the webinar

A tested and trusted IGRA for TB detection

Over the past 15 years, laboratory-based TB interferon gamma release assays (IGRAs) have been transforming screening programs with higher accuracy, operational advantages and improved convenience. QuantiFERON technology has been the subject of over 1500 clinical and scientific studies.

QFT-Plus uses an IGRA to measure the T cell immune response to MTB and provides the convenience of a single patient visit with electronic reporting, quantitative results and high accuracy. It is endorsed by the WHO, embraced by the UN and IPPA and among the WHO’s 120 essential diagnostic tests.

Watch Dr. Riccardo Alagna discuss the performance of QFT-Plus in different patient categories.

Top 3 reasons to choose QFT-Plus

Four tubes, one clear result
QFT-Plus requires just 4 ml of whole blood - either 1 ml in each of the 4 QFT-Plus tubes or into a standard heparin tube. Test results are calculated using a lab-based ELISA assay.
go to qft workflow
CD8 T cell technology
CD8 T cells have been shown to play an important role in MTB immunity (8–10). QFT-Plus measures the cell-mediated immune response to MTB infection from both CD4 and CD8 T cells.
DISCOVER CD8 TECHNOLOGY
Automated testing solution
The LIAISON® QuantiFERON-TB Gold Plus* solution allows laboratories to easily benefit from an automated and efficient workflow for less hands-on time & improved time to results.
EXPLORE AUTOMATED TESTING

QIAreach QFT: IGRA testing for every setting**

Ensuring access to TB testing where it’s needed the most.

Learn More

References:

QuantiFERON-TB Gold Plus (QFT-Plus) ELISA Package Insert. Current QFT-Plus package inserts are available at www.QuantiFERON.com
Diel, R., Loddenkemper, R., and Nienhaus, A. (2010) Chest 137, 952.
Harada, N. et al. (2008) J. Infect. 56, 348.
Tuberculin Purified Protein Derivative (Mantoux) TUBERSOL® Package insert. Sanofi Pasteur Limited. February 2013. R8-2013.
Pai, M., Zwerling, A., and Menzies, D. (2008) Ann Intern Med 149, 177–184.
Pareek, M. et al. (2013) Thorax 68, 230.
Nienhaus A, et al. (2007) Arch. Occup. Environ. Health. 81, 295–300.
Turner, J. et al. (1996) Immunology 87, 339.
Brookes, R.H. et al. (2003) Eur. J. Immunol. 33, 3293.
Stenger, S. et al. (1998) Science 282, 121.

*QuantiFERON-TB Gold Plus Blood Collection Tubes by QIAGEN and LIAISON Analyzer by DiaSorin.

**QIAreach QuantiFERON-TB is intended for high TB-burden countries.

Product claims may differ from country to country based on regulations and approvals. Contact your country representative for further details.

QFT-Plus is an in vitro diagnostic aid for detection of Mycobacterium tuberculosis infection. QFT-Plus is an indirect test for M. tuberculosis infection (including disease) and is intended for use in conjunction with risk assessment, radiography, and other medical and diagnostic evaluations. QFT-Plus Package Inserts, available in multiple languages, as well as up-to-date licensing information and product-specific disclaimers can be found at www.QuantiFERON.com.

QuantiFERON-TB products