Diet-microbe-host interaction in early life
About the session
To promote the health of preterm babies, a better understanding of the interplay between gut microbes, host and diet is needed. For example, specific oligosaccharides from the mother’s milk can module the gut microbiome and significantly reduce the risk of necrotizing enterocolitis and late-onset sepsis in the infant. Based on the multi-omicanalysis of clinical samples, together with microbiome and metabolomic profiling and basic microbiology, we linked diet-microbe-host interactions to a range of health and disease outcomes. We also use a human intestinal organoid model system to advance our gut microbiome work. This session, will cover how the microbiome develops in infants and discuss the potential to develop novel disease biomarkers and targeted therapeutic interventions while focusing on promoting the health of preterm infants.
Newcastle University, UK.
Dr Christopher Stewart is a Wellcome Trust Sir Henry Dale Research Fellow and 2021 Lister Institute Prize Fellow at Newcastle University, UK. He gained a PhD in Microbial Ecology at Northumbria University, followed by postdoctoral training at Baylor College of Medicine, Houston Texas. He has researched the early life microbiome in health and disease for over 10 years, publishing over 80 peer-reviewed manuscripts. His lab currently focuses on the interactions between microbes and host in the guts of infants born prematurely (<32 weeks’ gestation).