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Cignal Reporter Assay Kits

For rapid, sensitive, and quantitative assessment of signal transduction pathway activation

  • Rapid analysis of signal transduction pathway regulation
  • Exceptional sensitivity and specificity
  • Transfection-ready constructs
  • Includes positive and negative controls
  • Real-time live cell quantification (GFP format)

Cignal Reporter Assays provided in the Cignal Reporter Assay Kit enable rapid, sensitive, and quantitative assessment of signal transduction pathway activation by measuring the activities of downstream transcription factors. Two reporter systems are available: dual-luciferase format and GFP format.

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Cignal Reporter Assay Kits are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease.


0
TNFα activates NFkB signaling activity in a dose-dependent manner.
293 H cells were transfected with Cignal NFkB Reporter Assay, negative or positive control. After 24 hours, cells were treated with different doses of hTNFα for a further 24 hours. Dual-luciferase assays were performed, and reporter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and standard deviation is shown.
1
Assessing RNA interference phenotypes.

Cignal p53 Reporter Assays showed that p53 siRNA treatment abolished p53 transcription activity. HCT 116 cells were transfected with p53 reporter, negative control, and positive control, together with p53 siRNA or negative control siRNA. Dual-luciferase assays were performed. Reporter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and the standard deviation is shown.

2
Assessing overexpression phenotypes.

Cignal RBP-Jκ Reporter Assay showed upregulation of Notch signaling activity after overexpression of activated Notch1. 293 H cells were transfected with RBP-Jκ reporter, negative control, and positive control. After 24 hours, cells were infected with 100 MOI of recombinant adenoviruses expressing activated Notch1 (Ad-NICD) or 100 MOI of recombinant adenovirus expressing GFP (Ad-GFP) for another 18 hours. Dual-luciferase assays were performed. Reporter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and the standard deviation is shown.

3
Verification of small molecule drug candidate.

Cignal Retinoic Acid Response Element (RARE) Reporter Assay reported elevated retinoic acid receptor pathway activity after the treatment of all trans-retinoic acid (ATRA). CHO-K1 cells were transfected with RARE reporter, negative control, and positive control. After 16 hours, medium was changed to assay medium. After 24 hours, cells were treated with 1 µM all trans-rectinoic acid (ATRA) for 6 hours. Dual-luciferase assay was performed, and promoter activity values are expressed as arbitrary units using a Renilla reporter for internal normalization. Experiments were performed in triplicate and the standard deviation is shown.

4
Cignal Reporter Assay shows that hTNFa activated NFkB signaling pathway.
293 H cells were transfected with the Cignal NFkB-GFP Reporter Assay or negative control. After 16 hours, medium was changed to assay medium. After 24 hours, cells were treated with 10 ng/ml TNFα. After 18 hours, medium was removed from the wells and fluorescence activity was measured using a fluorometer. The fluorescence activity present in treated and nontreated negative control wells was subtracted from the fluorescence activity in treated and nontreated Cignal NFkB-GFP Reporter Assay wells and relative fluorescence activities expressed as arbitrary units. Experiments were performed in triplicate and the standard deviations are shown.
5
Cignal Reporter Assay measures activation of serum response factor (SRF) transcription activity.

293 H cells were transfected with the Cignal SRF-GFP Reporter Assay or negative control. After 16 hours, medium was changed to assay medium. After 24 hours, cells were treated with 10 ng/ml PMA and 10% serum. After 18 hours, medium was removed from the wells and fluorescence activity was measured using a fluorometer. The fluorescence activity present in treated and nontreated negative control wells was subtracted from the fluorescence activity in treated and nontreated Cignal SRF-GFP Reporter Assay wells and relative fluorescence activities expressed as arbitrary units. Experiments were performed in triplicate and the standard deviations are shown.

6
Cignal Reporter Assay procedure.
7
Cignal Reporter Assay principle.
Performance
Principle

Cignal Reporter Assays consist of multiple repeats of a specific transcription factor’s binding site and basic promoter elements to drive the expression of a reporter gene (firefly luciferase or GFP). These reporters are powerful tools in functional genomics and drug discovery for assessing pathway activity. When the pathway is activated or inhibited by a drug candidate, gene knockdown, overexpression, or peptide, luciferase or GFP reporter activity is modulated and can be measured quantitatively and rapidly (see figure "Cignal Reporter Assay principle"). The Cignal Reporter Assays are available as transfection-ready constructs utilizing two reporter systems: the dual-luciferase reporter or the GFP reporter (see flowchart "Cignal Reporter Assay procedure").

The dual-luciferase format is an end-point assay providing unsurpassed sensitivity, specificity, and signal-to-noise ratios. This format is available for all Cignal Reporter Assays. Each assay includes a pathway-focused transcription factor reporter and a noninducible negative control, as well as luciferase and GFP positive controls.

The GFP format is an outstanding method for monitoring live cell pathway regulation, with single cell resolution. It includes a pathway-focused transcription factor reporter and positive and negative controls.

Procedure

Cignal Reporter Assays include a preformulated, transfection-ready pathway reporter (dual-luciferase or GFP), plus a positive and negative control. The inducible pathway reporter and noninducible negative control are transfected and subjected to experimental treatments in parallel.

Dual-luciferase

Dual-luciferase results are calculated for each transfectant. The change in the activity of each signaling pathway is determined by comparing the normalized luciferase activities of the reporter in treated versus untreated transfectants. The identically treated negative control transfectants serve as a specificity control. The positive control serves as a control for transfection efficiency, by monitoring firefly luciferase and Renilla expression.

GFP

GFP expression is quantified using a flow cytometer, fluorescence microscope, or fluorometer. The change in the activity of each signaling pathway is determined by comparing the GFP activities in treated versus untreated transfectants. The identically treated negative control transfectants serve as a specificity control. The positive control serves as a control for transfection efficiency, by monitoring GFP expression from the constitutively expressing CMV-GFP reporter.

Applications

Cignal Reporter Assays are powerful tools in functional genomics, proteomics, and drug discovery for assessing the biological impact of pathway inhibition or activation with siRNAs, proteins, and small molecule compounds.

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Brochures & Guides (1)
For cell-based analysis of pathway signaling activity
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Kit Handbooks (1)
Transfection Protocols (2)
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Transfection protocols for specific cell types and plate formats that save you the time and effort of adapting existing protocols to fit your requirements. Simply select the cell type, nucleic acid, and culture format to receive a QIAGEN transfection protocol to print out or download in convenient PDF format.
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C/EBP Reporter Assay Kit (GFP) Cignal Reporter Assay Kits
Introduction
The Cignal C/EBP Reporter Assay Kit is designed to monitor the activity of C/EBP-regulated signal transduction pathways in cultured cells. The CCAAT/enhancer-binding protein, C/EBP, is a basic leucine zipper transcription factor that is involved in the regulation of mitotic growth arrest and differentiation. The kit contains transfection-ready C/EBP reporter as well as positive and negative controls. The C/EBP reporter encodes the Monster GFP gene under the control of a minimal (m)CMV promoter and tandem repeats of the C/EBP transcriptional response element (TRE). We have experimentally optimized the number of response elements as well as the intervening sequence between response elements to maximize the signal to noise ratio.
CCS-1001G

The Cignal C/EBP Reporter Assay detects C/EBP transcription activity. 293-H cells were transfected with the Cignal C/EBP Reporter, negative control, and positive control (for the transfection protocol, refer to the Cignal Reporter Assay Handbook). After 16 hours of transfection, medium was changed to assay medium (Opti-MEM + 0.5% FBS + 0.1 mM NEAA + 1 mM sodium pyruvate). After 24 hours of transfection, cells were [A] and [C] untreated, or [B] and [D] treated with 20 mM LiCl for 24 hours. Bright field and fluorescent images were taken of the cultures transfected with the Cignal C/EBP-GFP Reporter.
Name Cignal C/EBP Reporter (GFP) (CCS-1001G)
Official symbol CXCL8 [Human]
Official name chemokine (C-X-C motif) ligand 8
Species Human (Homo sapiens)
Entrez Gene ID 3576
Transcript(s) for this gene NM_000584 (1718 bp), ENST00000483500, ENST00000307407, ENST00000401931
Official symbol CEBPA [Human]
Official name CCAAT/enhancer binding protein alpha
Species Human (Homo sapiens)
Entrez Gene ID 1050
Transcript(s) for this gene NM_004364 (2631 bp), NM_001285829 (2631 bp), NM_001287424 (2631 bp), NM_001287435 (2631 bp), ENST00000498907
Official symbol Cebpa [Mouse]
Official name CCAAT/enhancer binding protein (C/EBP), alpha
Species Mouse (Mus musculus)
Entrez Gene ID 12606
Transcript(s) for this gene NM_007678 (2651 bp), NM_001287514 (2636 bp), NM_001287515 (2636 bp), NM_001287521 (2636 bp), NM_001287523 (2636 bp)
Official symbol Cebpa [Rat]
Official name CCAAT/enhancer binding protein (C/EBP), alpha
Species Rat (Rattus norvegicus)
Entrez Gene ID 24252
Transcript(s) for this gene NM_012524 (2673 bp), NM_001287577 (2673 bp), NM_001287578 (2673 bp), NM_001287579 (2673 bp)
Official symbol CRP [Human]
Official name C-reactive protein, pentraxin-related
Species Human (Homo sapiens)
Entrez Gene ID 1401
Transcript(s) for this gene NM_000567 (2024 bp), ENST00000489317, ENST00000255030, ENST00000368110, ENST00000368111, ENST00000368112, ENST00000437342
Official symbol Crp [Mouse]
Official name C-reactive protein, pentraxin-related
Species Mouse (Mus musculus)
Entrez Gene ID 12944
Transcript(s) for this gene NM_007768 (1698 bp)
Official symbol Crp [Rat]
Official name C-reactive protein, pentraxin-related
Species Rat (Rattus norvegicus)
Entrez Gene ID 25419
Transcript(s) for this gene NM_017096 (693 bp)
Official symbol ADIPOQ [Human]
Official name adiponectin, C1Q and collagen domain containing
Species Human (Homo sapiens)
Entrez Gene ID 9370
Transcript(s) for this gene NM_001177800 (4629 bp), NM_004797 (4578 bp), ENST00000320741, ENST00000444204
Official symbol Adipoq [Mouse]
Official name adiponectin, C1Q and collagen domain containing
Species Mouse (Mus musculus)
Entrez Gene ID 11450
Transcript(s) for this gene NM_009605 (1233 bp)
Official symbol EPHX1 [Human]
Official name epoxide hydrolase 1, microsomal (xenobiotic)
Species Human (Homo sapiens)
Entrez Gene ID 2052
Transcript(s) for this gene NM_000120 (1847 bp), NM_001136018 (1699 bp), ENST00000467015, NM_001291163 (2085 bp), ENST00000272167, ENST00000366837, ENST00000614058
Official symbol Ephx1 [Mouse]
Official name epoxide hydrolase 1, microsomal
Species Mouse (Mus musculus)
Entrez Gene ID 13849
Transcript(s) for this gene NM_010145 (1754 bp), NM_001312918 (1712 bp)
Official symbol Ephx1 [Rat]
Official name epoxide hydrolase 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 25315
Transcript(s) for this gene NM_001034090 (1732 bp), NM_012844 (1761 bp)
Official symbol Cdkn1a [Mouse]
Official name cyclin-dependent kinase inhibitor 1A (P21)
Species Mouse (Mus musculus)
Entrez Gene ID 12575
Transcript(s) for this gene NM_001111099 (1943 bp), NM_007669 (1913 bp)
Official symbol Cyp3a41b [Mouse]
Official name cytochrome P450, family 3, subfamily a, polypeptide 41B
Species Mouse (Mus musculus)
Entrez Gene ID 100041375
Transcript(s) for this gene NM_001105159 (2064 bp), XM_001476442 (2064 bp), XM_006504778 (1777 bp)
Official symbol IL1B [Human]
Official name interleukin 1, beta
Species Human (Homo sapiens)
Entrez Gene ID 3553
Transcript(s) for this gene NM_000576 (1498 bp), ENST00000496280, ENST00000491056, XM_006712496 (1692 bp), ENST00000263341
Official symbol Il1b [Mouse]
Official name interleukin 1 beta
Species Mouse (Mus musculus)
Entrez Gene ID 16176
Transcript(s) for this gene NM_008361 (1348 bp), ENSMUST00000155994, XM_006498795 (2649 bp)
Official symbol Il1b [Rat]
Official name interleukin 1 beta
Species Rat (Rattus norvegicus)
Entrez Gene ID 24494
Transcript(s) for this gene NM_031512 (1339 bp)
Official symbol CEBPZ [Human]
Official name CCAAT/enhancer binding protein zeta
Species Human (Homo sapiens)
Entrez Gene ID 10153
Transcript(s) for this gene NM_005760 (3341 bp), ENST00000489306, ENST00000234170, ENST00000619061
Official symbol Cebpz [Mouse]
Official name CCAAT/enhancer binding protein zeta
Species Mouse (Mus musculus)
Entrez Gene ID 12607
Transcript(s) for this gene NM_001024806 (4091 bp), NM_009882 (3552 bp), XM_006523558 (2476 bp)
Official symbol Cebpz [Rat]
Official name CCAAT/enhancer binding protein zeta
Species Rat (Rattus norvegicus)
Entrez Gene ID 362686
Transcript(s) for this gene NM_001108701 (4004 bp), XM_001059054 (4691 bp), XM_343002 (4691 bp)
Official symbol Spi1 [Mouse]
Official name spleen focus forming virus (SFFV) proviral integration oncogene
Species Mouse (Mus musculus)
Entrez Gene ID 20375
Transcript(s) for this gene NM_011355 (1333 bp), XM_001003437 (1019 bp), XR_104692 (613 bp), XR_107375 (617 bp), ENSMUST00000131400, XM_006499038 (1434 bp)
Official symbol SPI1 [Human]
Official name Spi-1 proto-oncogene
Species Human (Homo sapiens)
Entrez Gene ID 6688
Transcript(s) for this gene NM_001080547 (1426 bp), NM_003120 (1423 bp), ENST00000227163, ENST00000378538, ENST00000533030, ENST00000533968
Official symbol Spi1 [Rat]
Official name Spi-1 proto-oncogene
Species Rat (Rattus norvegicus)
Entrez Gene ID 366126
Transcript(s) for this gene NM_001005892 (1373 bp), XM_006234532 (2222 bp)
Official symbol Il6 [Mouse]
Official name interleukin 6
Species Mouse (Mus musculus)
Entrez Gene ID 16193
Transcript(s) for this gene NM_031168 (1141 bp), NM_001314054 (1083 bp)
Official symbol IL6 [Human]
Official name interleukin 6
Species Human (Homo sapiens)
Entrez Gene ID 3569
Transcript(s) for this gene NM_000600 (1201 bp), ENST00000485300, XM_005249745 (1412 bp), ENST00000258743, ENST00000401630, ENST00000401651, ENST00000404625, ENST00000406575, ENST00000407492
Official symbol Il6 [Rat]
Official name interleukin 6
Species Rat (Rattus norvegicus)
Entrez Gene ID 24498
Transcript(s) for this gene NM_012589 (1045 bp)
Official symbol Sp1 [Mouse]
Official name trans-acting transcription factor 1
Species Mouse (Mus musculus)
Entrez Gene ID 20683
Transcript(s) for this gene NM_013672 (7818 bp), ENSMUST00000170042, XM_006520673 (7851 bp), XM_006520674 (7713 bp), XM_011245533 (7864 bp)
Official symbol SP1 [Human]
Official name Sp1 transcription factor
Species Human (Homo sapiens)
Entrez Gene ID 6667
Transcript(s) for this gene NM_001251825 (7523 bp), NM_003109 (7614 bp), NM_138473 (7667 bp), XM_006719570 (7905 bp), XM_006719571 (7761 bp), ENST00000327443, ENST00000426431
Official symbol Sp1 [Rat]
Official name Sp1 transcription factor
Species Rat (Rattus norvegicus)
Entrez Gene ID 24790
Transcript(s) for this gene NM_012655 (7718 bp)
Official symbol Calr [Mouse]
Official name calreticulin
Species Mouse (Mus musculus)
Entrez Gene ID 12317
Transcript(s) for this gene NM_007591 (1943 bp), ENSMUST00000154774
Official symbol CALR [Human]
Official name calreticulin
Species Human (Homo sapiens)
Entrez Gene ID 811
Transcript(s) for this gene NM_004343 (1929 bp), ENST00000590325, ENST00000316448
Official symbol Calr [Rat]
Official name calreticulin
Species Rat (Rattus norvegicus)
Entrez Gene ID 64202
Transcript(s) for this gene NM_022399 (1865 bp)
Official symbol Esr1 [Mouse]
Official name estrogen receptor 1 (alpha)
Species Mouse (Mus musculus)
Entrez Gene ID 13982
Transcript(s) for this gene NM_007956 (6248 bp), XM_985634 (3048 bp), XM_985672 (6199 bp), XM_985704 (6760 bp), ENSMUST00000149195, XM_006512432 (6377 bp), XM_006512433 (6250 bp), XM_006512434 (6173 bp), XM_006512435 (6123 bp), XM_006512436 (2916 bp), NM_001302531 (6218 bp), NM_001302532 (6358 bp), NM_001302533 (2730 bp), XM_011243066 (6188 bp), XM_011243067 (6189 bp), XM_011243068 (6158 bp), XM_011243069 (1346 bp)
Official symbol ESR1 [Human]
Official name estrogen receptor 1
Species Human (Homo sapiens)
Entrez Gene ID 2099
Transcript(s) for this gene NM_000125 (6330 bp), NM_001122740 (6357 bp), NM_001122741 (6314 bp), NM_001122742 (6466 bp), ENST00000488573, NM_001291230 (6320 bp), NM_001291241 (6311 bp), XM_006715374 (6282 bp), XM_006715375 (5809 bp), ENST00000206249, ENST00000338799, ENST00000406599, ENST00000427531, ENST00000440973, ENST00000443427, ENST00000456483
Official symbol Esr1 [Rat]
Official name estrogen receptor 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 24890
Transcript(s) for this gene NM_012689 (2090 bp), XM_006227832 (6792 bp), XM_008758703 (6840 bp), XM_008758704 (6764 bp)
Official symbol Ldlr [Mouse]
Official name low density lipoprotein receptor
Species Mouse (Mus musculus)
Entrez Gene ID 16835
Transcript(s) for this gene NM_001252658 (4393 bp), NM_001252659 (4546 bp), NM_010700 (4549 bp), XM_979020 (678 bp), XM_979059 (2823 bp), XM_979100 (1895 bp), XM_979131 (1925 bp), XM_979172 (2511 bp), XM_979210 (3017 bp), XM_979251 (3069 bp), XM_006510042 (2266 bp)
Official symbol LDLR [Human]
Official name low density lipoprotein receptor
Species Human (Homo sapiens)
Entrez Gene ID 3949
Transcript(s) for this gene NM_000527 (5292 bp), NM_001195798 (5286 bp), NM_001195799 (5169 bp), NM_001195800 (4788 bp), NM_001195802 (4929 bp), NM_001195803 (4758 bp), ENST00000560628, ENST00000455727, ENST00000535915, ENST00000545707, ENST00000557933, ENST00000558013, ENST00000558518
Official symbol Ldlr [Rat]
Official name low density lipoprotein receptor
Species Rat (Rattus norvegicus)
Entrez Gene ID 300438
Transcript(s) for this gene NM_175762 (3037 bp)
Official symbol Cebpb [Rat]
Official name CCAAT/enhancer binding protein beta
Species Rat (Rattus norvegicus)
Entrez Gene ID 24253
Transcript(s) for this gene NM_024125 (1475 bp), NM_001301715 (1475 bp), NM_001301720 (1475 bp)
Official symbol CEBPB [Human]
Official name CCAAT/enhancer binding protein (C/EBP), beta
Species Human (Homo sapiens)
Entrez Gene ID 1051
Transcript(s) for this gene NM_005194 (2113 bp), NM_001285878 (2113 bp), NM_001285879 (2113 bp), ENST00000303004
Official symbol Cebpb [Mouse]
Official name CCAAT/enhancer binding protein (C/EBP), beta
Species Mouse (Mus musculus)
Entrez Gene ID 12608
Transcript(s) for this gene NM_009883 (1518 bp), NM_001287738 (1518 bp), NM_001287739 (1518 bp)
Official symbol Cebpd [Rat]
Official name CCAAT/enhancer binding protein (C/EBP), delta
Species Rat (Rattus norvegicus)
Entrez Gene ID 25695
Transcript(s) for this gene NM_013154 (1139 bp)
Official symbol Nfkb1 [Rat]
Official name nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 81736
Transcript(s) for this gene XM_001075876 (3723 bp), XM_342346 (4088 bp), NM_001276711 (3956 bp), XM_006233358 (3612 bp), XM_006233360 (3434 bp)
Official symbol NFKB1 [Human]
Official name nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Species Human (Homo sapiens)
Entrez Gene ID 4790
Transcript(s) for this gene NM_001165412 (4090 bp), NM_003998 (4093 bp), ENST00000513803, XM_005263029 (4007 bp), XM_006714229 (3642 bp), ENST00000226574, ENST00000394820, ENST00000505458, ENST00000600343
Official symbol Nfkb1 [Mouse]
Official name nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Species Mouse (Mus musculus)
Entrez Gene ID 18033
Transcript(s) for this gene NM_008689 (4128 bp), ENSMUST00000150007, XM_006501105 (3394 bp), XM_006501106 (3618 bp), XM_006501107 (3808 bp)
Official symbol Lrpap1 [Rat]
Official name low density lipoprotein receptor-related protein associated protein 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 116565
Transcript(s) for this gene NM_001169113 (1414 bp), XM_001058156 (3488 bp), XM_341239 (3488 bp)
Official symbol LRPAP1 [Human]
Official name LDL receptor related protein associated protein 1
Species Human (Homo sapiens)
Entrez Gene ID 4043
Transcript(s) for this gene NM_002337 (10536 bp), ENST00000509198, ENST00000500728, NR_110005 (0 bp)
Official symbol Lrpap1 [Mouse]
Official name low density lipoprotein receptor-related protein associated protein 1
Species Mouse (Mus musculus)
Entrez Gene ID 16976
Transcript(s) for this gene NM_013587 (2922 bp), ENSMUST00000152028
Official symbol Cebpg [Rat]
Official name CCAAT/enhancer binding protein (C/EBP), gamma
Species Rat (Rattus norvegicus)
Entrez Gene ID 25301
Transcript(s) for this gene NM_012831 (1430 bp), XM_001079636 (2650 bp), XM_341842 (2536 bp), XM_008759112 (4633 bp)
Official symbol CEBPG [Human]
Official name CCAAT/enhancer binding protein (C/EBP), gamma
Species Human (Homo sapiens)
Entrez Gene ID 1054
Transcript(s) for this gene NM_001252296 (3647 bp), NM_001806 (3784 bp), ENST00000284000, ENST00000585933
Official symbol Cebpg [Mouse]
Official name CCAAT/enhancer binding protein (C/EBP), gamma
Species Mouse (Mus musculus)
Entrez Gene ID 12611
Transcript(s) for this gene NM_009884 (4718 bp), XM_485911 (1428 bp), XM_006539500 (3702 bp)
Official symbol Cdkn1a [Rat]
Official name cyclin-dependent kinase inhibitor 1A
Species Rat (Rattus norvegicus)
Entrez Gene ID 114851
Transcript(s) for this gene NM_080782 (1894 bp), XM_006256128 (1937 bp)
Official symbol Ddit3 [Rat]
Official name DNA-damage inducible transcript 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 29467
Transcript(s) for this gene NM_001109986 (861 bp), NM_024134 (813 bp), XM_006241444 (2034 bp), XM_006241445 (1986 bp)
Official symbol DDIT3 [Human]
Official name DNA-damage-inducible transcript 3
Species Human (Homo sapiens)
Entrez Gene ID 1649
Transcript(s) for this gene NM_001195053 (1081 bp), NM_001195054 (1028 bp), NM_001195055 (1005 bp), NM_001195056 (1191 bp), NM_001195057 (910 bp), NM_004083 (924 bp), ENST00000346473, ENST00000547303, ENST00000551116, ENST00000552740, ENST00000618206
Official symbol Ddit3 [Mouse]
Official name DNA-damage inducible transcript 3
Species Mouse (Mus musculus)
Entrez Gene ID 13198
Transcript(s) for this gene NM_007837 (888 bp), ENSMUST00000134686, NM_001290183 (840 bp), XM_006513196 (1471 bp), XM_006513197 (855 bp), XM_006513198 (785 bp)
Official symbol Adipoq [Rat]
Official name adiponectin, C1Q and collagen domain containing
Species Rat (Rattus norvegicus)
Entrez Gene ID 246253
Transcript(s) for this gene NM_144744 (1487 bp)
Official symbol CREB1 [Human]
Official name cAMP responsive element binding protein 1
Species Human (Homo sapiens)
Entrez Gene ID 1385
Transcript(s) for this gene NM_004379 (9752 bp), NM_134442 (9794 bp), ENST00000494983, XR_241289 (6030 bp), XR_241290 (7804 bp), XR_241292 (7689 bp), ENST00000353267, ENST00000430624, ENST00000432329
Official symbol Creb1 [Mouse]
Official name cAMP responsive element binding protein 1
Species Mouse (Mus musculus)
Entrez Gene ID 12912
Transcript(s) for this gene NM_001037726 (8267 bp), NM_009952 (8431 bp), NM_133828 (8389 bp), XM_006495650 (6715 bp), XM_006495651 (6673 bp), XM_006495652 (6581 bp), XM_006495653 (6529 bp), XM_006495654 (6487 bp), XM_006495655 (8423 bp), XM_011238424 (6736 bp), XM_011238425 (8094 bp)
Official symbol Creb1 [Rat]
Official name cAMP responsive element binding protein 1
Species Rat (Rattus norvegicus)
Entrez Gene ID 81646
Transcript(s) for this gene NM_031017 (1125 bp), NM_134443 (1023 bp), XM_006245065 (6691 bp), XM_006245066 (6856 bp), XM_006245067 (6596 bp), XM_006245068 (6543 bp), XM_006245069 (7193 bp), XM_006245070 (6063 bp), XM_008767138 (9047 bp), XM_008767139 (6917 bp)
Official symbol CYP3A4 [Human]
Official name cytochrome P450, family 3, subfamily A, polypeptide 4
Species Human (Homo sapiens)
Entrez Gene ID 1576
Transcript(s) for this gene NM_001202855 (2789 bp), NM_017460 (2792 bp), ENST00000480043, ENST00000336411, ENST00000354593
Official symbol SMARCA2 [Human]
Official name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Species Human (Homo sapiens)
Entrez Gene ID 6595
Transcript(s) for this gene NM_003070 (5892 bp), NM_139045 (5838 bp), ENST00000491574, NM_001289396 (5879 bp), NM_001289397 (5664 bp), NM_001289398 (1846 bp), NM_001289399 (1833 bp), NM_001289400 (2254 bp), ENST00000302401, ENST00000324954, ENST00000349721, ENST00000357248, ENST00000382185, ENST00000382186, ENST00000382194, ENST00000382203
Official symbol Smarca2 [Mouse]
Official name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Species Mouse (Mus musculus)
Entrez Gene ID 67155
Transcript(s) for this gene NM_011416 (5831 bp), NM_026003 (1964 bp), ENSMUST00000176700, XM_006527281 (6267 bp), XM_006527282 (5941 bp), XM_006527283 (6237 bp), XM_006527284 (5795 bp), XM_006527285 (6212 bp), XM_006527286 (5649 bp), XM_006527287 (1797 bp), XM_006527288 (1926 bp), XM_006527289 (1919 bp), XM_006527290 (1902 bp), XM_006527291 (1829 bp)
Official symbol Smarca2 [Rat]
Official name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Species Rat (Rattus norvegicus)
Entrez Gene ID 361745
Transcript(s) for this gene NM_001004446 (5928 bp), XM_006231227 (5939 bp), XM_006231229 (2040 bp), XM_008760331 (6253 bp), XM_008760332 (6301 bp), XM_008760333 (6041 bp), XM_008760334 (6073 bp), XM_008760335 (6009 bp), XM_008760336 (6321 bp), XM_008760337 (5871 bp), XM_008760338 (5507 bp), XM_008760339 (1942 bp)
Official symbol Abcb1a [Mouse]
Official name ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Species Mouse (Mus musculus)
Entrez Gene ID 18671
Transcript(s) for this gene NM_011076 (4977 bp), ENSMUST00000145232, ENSMUST00000126846, XM_006503555 (5177 bp), XM_006503556 (5138 bp)
Official symbol ABCB1 [Human]
Official name ATP-binding cassette, sub-family B (MDR/TAP), member 1
Species Human (Homo sapiens)
Entrez Gene ID 5243
Transcript(s) for this gene NM_000927 (4718 bp), ENST00000496821, ENST00000265724, ENST00000543898, ENST00000622132
Official symbol Cebpe [Mouse]
Official name CCAAT/enhancer binding protein (C/EBP), epsilon
Species Mouse (Mus musculus)
Entrez Gene ID 110794
Transcript(s) for this gene NM_207131 (1238 bp), XM_989335 (953 bp)
Official symbol CEBPE [Human]
Official name CCAAT/enhancer binding protein (C/EBP), epsilon
Species Human (Homo sapiens)
Entrez Gene ID 1053
Transcript(s) for this gene NM_001805 (1550 bp), ENST00000206513
Official symbol Cebpe [Rat]
Official name CCAAT/enhancer binding protein (C/EBP), epsilon
Species Rat (Rattus norvegicus)
Entrez Gene ID 25410
Transcript(s) for this gene NM_017095 (846 bp)
Official symbol Ep300 [Mouse]
Official name E1A binding protein p300
Species Mouse (Mus musculus)
Entrez Gene ID 328572
Transcript(s) for this gene NM_177821 (8749 bp), XM_006521089 (8768 bp), XM_006521090 (8747 bp), XM_006521091 (8241 bp)
Official symbol EP300 [Human]
Official name E1A binding protein p300
Species Human (Homo sapiens)
Entrez Gene ID 2033
Transcript(s) for this gene NM_001429 (8761 bp), XM_006724165 (8997 bp), ENST00000263253
Official symbol Ep300 [Rat]
Official name E1A binding protein p300
Species Rat (Rattus norvegicus)
Entrez Gene ID 170915
Transcript(s) for this gene XM_001076610 (9293 bp), XM_576312 (8309 bp), XM_006226166 (9272 bp), XM_008765878 (9260 bp)
Official symbol Jun [Mouse]
Official name jun proto-oncogene
Species Mouse (Mus musculus)
Entrez Gene ID 16476
Transcript(s) for this gene NM_010591 (3187 bp)
Official symbol JUN [Human]
Official name jun proto-oncogene
Species Human (Homo sapiens)
Entrez Gene ID 3725
Transcript(s) for this gene NM_002228 (3338 bp), ENST00000371222
Official symbol Jun [Rat]
Official name jun proto-oncogene
Species Rat (Rattus norvegicus)
Entrez Gene ID 24516
Transcript(s) for this gene NM_021835 (3107 bp)
Official symbol Invs [Mouse]
Official name inversin
Species Mouse (Mus musculus)
Entrez Gene ID 16348
Transcript(s) for this gene NM_010569 (5674 bp), ENSMUST00000156602, NM_001281977 (5622 bp), NM_001281978 (5900 bp), XM_006537626 (4810 bp), XM_006537627 (6807 bp), XM_006537628 (4780 bp), XM_006537629 (4768 bp), XM_006537630 (4642 bp), XM_006537631 (4636 bp), XM_006537632 (4630 bp), XM_006537633 (4481 bp), XM_006537634 (4315 bp), XM_006537635 (4303 bp), XM_006537636 (5872 bp), XM_006537637 (4994 bp), XM_011249937 (4584 bp)
Official symbol INVS [Human]
Official name inversin
Species Human (Homo sapiens)
Entrez Gene ID 27130
Transcript(s) for this gene NM_014425 (3889 bp), NM_183245 (3379 bp), ENST00000496467, ENST00000466647, ENST00000460636, XM_005251923 (3676 bp), XM_005251924 (3711 bp), ENST00000262456, ENST00000262457, ENST00000374921
Official symbol Tas1r3 [Mouse]
Official name taste receptor, type 1, member 3
Species Mouse (Mus musculus)
Entrez Gene ID 83771
Transcript(s) for this gene NM_031872 (3514 bp)
Official symbol TAS1R3 [Human]
Official name taste receptor, type 1, member 3
Species Human (Homo sapiens)
Entrez Gene ID 83756
Transcript(s) for this gene NM_152228 (2559 bp), XM_371210 (4600 bp), XM_006710939 (2168 bp), ENST00000339381
Official symbol Tas1r3 [Rat]
Official name taste receptor, type 1, member 3
Species Rat (Rattus norvegicus)
Entrez Gene ID 170634
Transcript(s) for this gene NM_130818 (2577 bp), XM_008764334 (4918 bp)
Official symbol Cebpd [Mouse]
Official name CCAAT/enhancer binding protein (C/EBP), delta
Species Mouse (Mus musculus)
Entrez Gene ID 12609
Transcript(s) for this gene NM_007679 (2260 bp), ENSMUST00000096232
Official symbol Retn [Mouse]
Official name resistin
Species Mouse (Mus musculus)
Entrez Gene ID 57264
Transcript(s) for this gene NM_001204959 (607 bp), NM_022984 (1139 bp), XM_006508846 (485 bp)
Official symbol RETN [Human]
Official name resistin
Species Human (Homo sapiens)
Entrez Gene ID 56729
Transcript(s) for this gene NM_001193374 (469 bp), NM_020415 (478 bp), ENST00000221515, ENST00000381324, ENST00000629642
Official symbol Retn [Rat]
Official name resistin
Species Rat (Rattus norvegicus)
Entrez Gene ID 246250
Transcript(s) for this gene NM_144741 (608 bp)
Official symbol CDKN1A [Human]
Official name cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Species Human (Homo sapiens)
Entrez Gene ID 1026
Transcript(s) for this gene NM_000389 (2175 bp), NM_001220777 (2119 bp), NM_001220778 (2284 bp), NM_078467 (2122 bp), NR_037150 (2327 bp), NR_037151 (2285 bp), NR_037152 (2120 bp), ENST00000478800, NM_001291549 (2325 bp), ENST00000244741, ENST00000373711, ENST00000405375, ENST00000448526, ENST00000615513
Official symbol CEBPD [Human]
Official name CCAAT/enhancer binding protein (C/EBP), delta
Species Human (Homo sapiens)
Entrez Gene ID 1052
Transcript(s) for this gene NM_005195 (1269 bp), ENST00000408965
Official symbol Invs [Rat]
Official name inversin
Species Rat (Rattus norvegicus)
Entrez Gene ID 313228
Transcript(s) for this gene NM_001107932 (5578 bp), XM_001056122 (3366 bp), XM_232983 (3375 bp)