Catalogue of Somatic Mutations in Cancer


  • Cited more than 10,000 times
  • Curated knowledge from more than 27,000 peer reviewed publications
  • Genome wide screen data from more than 37,000 genomes
  • More than 37 million somatic mutations
  • Cancer Gene Census


The COSMIC is intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
COSMIC Internal R&D Startup

Cat. No. / ID: 834320

Download, mine and use COSMIC for internal research and development purposes. Single Site license ideal for Research & Development organizations.
COSMIC Static Reporting Startup

Cat. No. / ID: 834321

Download, mine and use COSMIC for internal research and development purposes, and enhance your reports on genomic tests with COSMIC IDs. Single Site license ideal for hospitals and commercial testing laboratories.
COSMIC Dynamic Software Tool Startup

Cat. No. / ID: 834322

Download, mine and use COSMIC for internal research and development purposes, and share COSMIC content through analytical tools and services you develop on a per-query / analysis basis. Single Site license ideal for independend software application vendors and organizations who aim to develop an in-house analytical platform.

Product Details

COSMIC is the gold standard database for somatic mutation information.


COSMIC, the Catalogue Of Somatic Mutations In Cancer is the most detailed and comprehensive resource for exploring the effect of somatic mutations in human cancer. In addition to coding mutations, COSMIC covers all the genetic mechanisms by which somatic mutations promote cancer, including non-coding mutations, gene fusions, copy-number variants and drug-resistance mutations. It includes the Cancer Gene Census (CGC), an expert-curated library of cancer-driving genes in humans, and a standard in cancer genetics across basic research, medical reporting and pharmaceutical development.


COSMIC data are carefully selected, collected and standardized through manual curation by scientific experts, ensuring high quality, accuracy and descriptive data capture.


COSMIC data is available as a download, ready for you to integrate into your current pipelines and tools. You also will get access to any updates released during the one-year subscription period, as well as access to our support team.


Discover potential drug targets and biomarkers for cancer. Improve cohort selection for clinical trials. Identify driver mutations and relevant genes to support patient diagnosis.


COSMIC: the Catalogue Of Somatic Mutations In Cancer.
Tate JG; Bamford S; Jubb HC; Sondka Z; Beare DM; Bindal N; Boutselakis H; Cole CG; Creatore C; Dawson E; Fish P; Harsha B; Hathaway C; Jupe SC; Kok CY; Noble K; Ponting L; Ramshaw CC; Rye CE; Speedy HE; Stefancsik R; Thompson SL; Wang S; Ward S; Campbell PJ; Forbes SA;
Nucleic Acids Res; 2019; 47 (D1):D941-D947 2019 Jan 8 PMID:30371878
The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers.
Sondka Z; Bamford S; Cole CG; Ward SA; Dunham I; Forbes SA;
Nat Rev Cancer; 2018; 18 (11):696-705 2018 Nov PMID:30293088