Lymphoma

Lymphoma is typically a solid tumor of mature white blood cells in lymphoid tissue. The major clinical and pathological subtypes of adulthood lymphoma include follicular lymphoma and diffuse large B-cell lymphoma. However, the World Health Organization recognizes 70 different forms of lymphoma. Lymphomas typically affect the lymph nodes, unlike leukemia, which affects the bone marrow. The molecular and biological pathways responsible for cell adhesion, cell cycle, PI-3-Kinase/AKT signaling, and T cell differentiation are dysregulated during lymphoma. Dysregulated gene expression, mutations, and differentially methylated promoters are routinely detected in molecular analyses of lymphoma samples. Analyzing and monitoring these affected pathways may lead to a better understanding of the molecular mechanisms behind lymphoma development, classification, and therapeutic response.

QIAGEN provides a broad range of assay technologies for lymphoma research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. Solutions optimized for lymphoma studies include PCR array, miRNA, siRNA, mutation analysis, pathway reporter, chromatin IP, DNA methylation, and protein expression products.