Ingenuity Variant Analysis
For identifying disease-causing variants from human whole genome, exome and gene panel next-generation sequencing studies
Ingenuity Variant Analysis is the leading application for analysis and interpretation of human sequencing data generated with next-generation sequencing (NGS) technologies. The application uses accurate, curated biological content from the Ingenuity Knowledge Base, plus many additional sources of variant-level content, to help researchers studying genetics and disease biology to quickly sift through millions of variants and identify causal variants based on known relationships with pathways, genes, biological processes, and diseases. Sharing features enable collaboration with colleagues and peers, and data and graphics can be exported to aid in manuscript preparation for publication.
The Ingenuity Variant Analysis is intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
Intuitive, user-friendly interfaceNo bioinformatics skills are needed to benefit from Ingenuity Variant Analysis. The software is easy to learn and use in your own workspace without any waiting time for additional resources to get started.
Interactive filter cascadeA basic set of filters enables elimination of common and nondeletrious variants, quickly reducing the number of variants significantly. Next, application of additional filters based on your knowledge of disease further reduces the number from millions to hundreds of interesting variants for follow-on studies.
Iterative analysisIngenuity Variant Analysis mirrors the investigative process, allowing rapid application of a hypothesis, visualization and evaluation of results, and reiteration of the hypothesis, providing immediate results that speed discovery.
Sharing and publication toolsEasy-to-use tools allow collaboration with colleagues and peers. Data and graphics can be exported to aid in manuscript preparation for publication.
Knowledge-driven algorithms and analyticsKeyword search within the Ingenuity ontology provides identification and prioritization of compelling variants using both your knowledge of disease, phenotypes, processes, and pathways and the deep pathway information available in the Ingenuity Knowledge Base.
Causal Network AnalyticsVariants in genes within one or 2 network 'hops' of upstream or downstream genes are identified by Causal Network Analytics. Understand not only known relationships, but also variants in genes that have relationships or interactions with those genes known to be associated.
Curated up-to-date content at your fingertipsNo need to go search for publications on your own. Ingenuity Variant Analysis provides a knowledge base containing millions of biomedical findings and mutations derived from the literature and public databases, which is accurate, updated, and curated by experts. Access up-to-date pathways, processes, models, genetic, drug and disease findings seamlessly, within a single, easy-to-use interface.
Scalable processing capacityIngenuity Variant Analysis has been demonstrated to support study sizes ranging from individuals and trios to thousands of samples in a single analysis. Analyze thousands of samples simultaneously.
Unparalled database knowledgeIngenuity Variant Analysis leverages the Ingenuity Knowledge Base, a repository of expertly curated biological interactions and functional annotations created from millions of individually modeled relationships between proteins, genes, complexes, cells, tissues, drugs, and diseases. These modeled relationships include rich details, links to the original article, and are reviewed for accuracy by Ph.D. scientists. The curated content in the Knowledge Base is structured into an ontology that allows for contextual information, computation by the applications, and synonym resolution to ensure consistency across concepts. These features make the Ingenuity Knowledge Base distinctive and unparalleled by any other database.
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