Recent advances in NGS chemistries, platforms, and bioinformatics pipelines are enabling users to efficiently interrogate biological samples for changes in DNA and RNA. Current approaches, however, require the use of 2 separate workflows to prepare libraries from separate DNA and RNA isolates. Limitations of such approaches include:
- Large amounts of sample material required for generating sufficient amounts of input DNA and RNA for multiple workflows
- Added complexity of deriving integrated insights from results of different technical approaches, each with its own innate bias
- Inefficient use of resources
- Long turn-around times
To overcome the limitations associated with current approaches, QIAseq Multimodal Panels start with total nucleic acids (or DNA + RNA) and prepares UDI-containing, Illumina-compatible targeted DNA and RNA libraries using a single-day, consolidated workflow. In addition, QIAseq Multimodal Panels have been designed for use with low-yield and poor-quality biological samples.