1. Insert the EZ1 Advanced XL Card with the desired protocol into the card slot and start the instrument. 2. Place samples and prefilled, sealed reagent cartridges into the instrument. Samples are processed automatically and purified nucleic acids are transferred to elution tubes. 3. Remove pure nucleic acids in 1.5 ml microcentrifuge tubes at a concentration suited to the downstream application.

The EZ1 Advanced XL has been designed to ensure high process safety, high performance, and user convenience. A sensor ensures that the instrument door remains closed during sample preparation, reducing contact of laboratory personnel with potentially infectious samples and protecting sample integrity. At the end of each run, an intelligent-design UV lamp decontaminates the inner surface of the instrument. If required, the instrument can be placed in a safety cabinet, providing increased user safety.

A wide range of preprogrammed protocols, without the need for any manual data entry, are available on EZ1 Advanced XL Cards for purification of DNA, RNA, or viral nucleic acids. New cards may be purchased — increasing the range of purification protocols without any retraining or costly modifications to the instrument.

The EZ1 Advanced XL instrument sets new standards in data management. Barcode reading enables complete tracking of samples and reagents throughout the entire purification process. For increased process control and reliability, reagent identification and lot numbers are logged together with the expiration date, and a warning is issued if the expiration date has been exceeded. The run report is compatible with subsequent processing by a Laboratory Information Management System (LIMS).