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QIAcube Connect

For fully automated nucleic acid extraction with QIAGEN’s spin-column kits
  • Automates over 80 QIAGEN kits with over 140 standard protocols for the most frequently used applications
  • Optional protocol customization expands the use to virtually any application
  • Allows automated DNA, RNA and protein sample processing
  • Eliminates manual processing steps
  • Generates standardized results 
  • Enables quick response times and remote run monitoring through the provided tablet

QIAcube Connect is redefining the benefits of automating sample processing. With advanced digital capabilities and connectivity QIAcube Connect with its accessories and consumables allows research labs to fully automate and track their well known QIAGEN spin-column extraction and purification protocols – at the push of a button.

QIAcube Connect offers an augmented user interface that provides a new dimension of utility. Researchers can stay connected to their instrument through the built-in screen and also remotely with a tablet (included), containing the pre-installed QIAcube Connect App, enabling quick response times and ability to monitor runs while away from the QIAcube Connect.

Explore the demo tool to learn more about QIAcube Connect.

QIAcube Connect operates in conjunction with QIAcube Connect Accessories.

To find resources for the QIAcube, visit the QIAcube (classic) resource page.

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Cat No./ID: 9002864
QIAcube Connect
Instrument, 1-year warranty on parts and labor
Cat No./ID: 990395
Starter Pack, QIAcube

200 µl filter-tips (1024); 1000 µl filter-tips (1024); 30 ml reagent bottles (12); rotor adapters (240); 1.5 ml elution tubes (240); rotor adapter holder (1)

QIAcube Connect is designed to perform fully automated purification of nucleic acids and proteins in molecular biology applications. The system is intended for use by professional users trained in molecular biological techniques and the operation of QIAcube Connect.

Product Details

The QIAcube Connect worktable
The features of the QIAcube Connect worktable, which lets you process up to 12 samples, include: 3 tip/enzyme racks for easy loading, a sample tube holder/shaker, bottle racks for your reagents, a robotic arm with sensors and a UV light for decontamination.
Automated QIAprep Mini standard procedure
Using the QIAcube Connect. Fully automated purification of nucleic acids or proteins using QIAGEN spin kits, such as QIAprep Mini kits, on the QIAcube Connect eliminates the need for tedious manual steps. Sample preparation on the QIAcube Connect follows the same steps as the manual procedure (i.e., lysis, bind, wash and elute). No change in purification chemistry is required.
The QIAcube Connect touchscreen
The QIAcube Connect has a large integrated touchscreen that simplifies protocol selection, and clear on-screen messages guide the user through worktable setup, taking ease-of-use to the next level.
The QIAcube Connect UV light
The QIAcube Connect instrument comes with a built-in UV light source that enables full worktable decontamination, and prevents any sample carryover.

The revolutionary QIAcube Connect makes automated sample prep available to all laboratories. The plug-and-play instrument simplifies and streamlines your purification procedures by fully automating the trusted QIAGEN spin-column kits. No change of chemistry is required, assuring fast startup and immediate results, and performance is comparable to the manual procedure. The innovative QIAcube Connect enables you to free up your valuable time, continue to use proven QIAGEN spin-column kits, standardize your results and increase your productivity. 


QIAcube Connect enables continued use of well-established QIAGEN spin-column kits and eliminates the need for tedious manual steps. The innovative QIAcube Connect controls integrated components including a centrifuge, heated shaker, pipetting system and robotic gripper (see figure The QIAcube Connect worktable). This enables the QIAcube Connect to fully automate more than 80 QIAGEN spin column kits. 

UV light decontamination

You can now achieve convenient and efficient full worktable decontamination with the new built-in UV light of the QIAcube Connect (see figure ''The QIAcube Connect principle''). By making use of the UV light decontamination feature of our enhanced instrument, you can prevent any carryover between samples, allowing for a single instrument to purify DNA, RNA, pathogen nucleic acids and proteins from a vast array of sample types (see figure Genomic DNA (gDNA) barely detectable after UV light exposure'').

Remote connectivity

With the new QIAcube Connect you can now spend less time preparing your sample prep run and waiting around for your results, and more time thinking about your research! That’s because the new QIAcube Connect comes with a tablet that allows for easier sample prep run preparation, and provides you with status updates on the progress of your run (see figure ''The QIAcube Connect principle''). Furthermore, the QIAcube Connect comes with a barcode scanner. Simply scan the barcode of your sample prep kit, and all the necessary kit information will immediately appear on your screen.

Illuminated worktable

The QIAcube Connect is provided with a light inside the instrument, making it easier to load your samples and perform your experiments.

Protocols for various sample types

The QIAcube Connect is provided with a variety of pre-installed protocols for purification of RNA, genomic DNA, plasmid DNA, viral nucleic acids and proteins, plus DNA and RNA cleanup. All standard protocols in the expanding range can also be downloaded free of charge. Customized protocols tailored to meet your specific application demands can also be requested.


QIAcube Connect enables purification of highly pure nucleic acids or proteins using a simple lysis, bind, wash and elute procedure (see figure ''Automated QIAprep Mini Standard procedure'').

Unparalleled ease-of-use

With QIAcube Connect, ease-of-use is taken to a new level. A large integrated touchscreen (see figure ''The QIAcube Connect touchscreen'') simplifies protocol selection, and clear on-screen messages guide the user through worktable setup. For increased ease-of-use and high process safety, labware and accessories fit onto the worktable only in the correct orientation. In addition, a fully automated load check helps to ensure that samples, reagents and labware are loaded correctly.

Dedicated kits for DNA and RNA preps

Dedicated QIAcube Connect kits further simplify automated spin-preps on QIAcube Connect, and increase convenience. Kits are currently available for purification of RNA, genomic DNA and viral RNA. Rotor-adapters supplied with the kits are pre-loaded with spin columns and elution tubes, delivering greater convenience and time saving. Furthermore, ease-of-use is increased, user errors are minimized and waste is reduced, as the content of the dedicated kits is tailored to purification on QIAcube Connect, and tubes required for the manual procedure are not included.


QIAcube Connect is highly suitable for academic research laboratories as well as pharmaceutical, biotechnology, and biomedical research laboratories performing applications, such as:

  • Sequencing/sequencing analysis
  • Gene expression analysis
  • Genotyping
  • Proteomics 
  • Microbiome research

Have your throughput demands increased? Do you want to expand your application range or further streamline workflows? Do you need to manage more complex samples? Do you need improved connectivity?

If the answer to any of these questions is yes, then QIAGEN’s trade-in/trade-up program is just right for you!

QIAGEN makes it easy to keep up to speed with the latest automation and sample processing technologies. Simply exchange an old instrument for a new one. Improve your efficiency by trading in a competitor instrument or trading up with an older QIAGEN instrument.

Learn more about trade-in/trade-up opportunities.


Altitude Up to 2000 m (6500 ft)
Centrifuge 10,640 rpm maximum, 12,000 x g maximum, swing-out rotor maximum 45°, 12 rotor positions
Data output USB stick: USB2.0; Compatible OS: Windows 8, Windows 7, Windows Vista, Windows XP (SP3 or later); Mac OS x 10,1 or later; Operating temperature range: 0ºC to 35ºC; Operating humidity range: 10 to 90% (with no condensation); Storage temperature range: –20ºC to 60ºC (–4ºF to 140ºF); Storage humidity range: 10 to 90% (with no condensation); Formatting: FAT32
Environmental class 3K2 (IEC 60721-3-3)
Instrument dimensions Dimensions (hood closed): width 65 cm (25.6 in.), height 58 cm (22.8 in.), depth 62 cm (24.4 in.); Dimensions (hood open): width 65 cm (25.6 in.), height 86 cm (34 in.), depth 62 cm (24.4 in.); Mass: QIAcube Connect: 71.5 kg (157.6 lb.), Accessories: 3 kg (6.6 lb.)
Operating temperature 18 to 28ºC (64.4 to 82.4ºF)
Pipetting system Syringe size 1 ml, pipetting range 5–900 µl
Place of operation For indoor use only
Pollution level 2
Relative humidity 15–75% (non-condensing)
Shaker Speed 100–2000 rpm, amplitude 2 mm, heating range of ambient temperature to 70°C (158°F), ramp-up time of <5 minutes from ambient temperature to 55°C (±3°C). Difference in the temperature detected by the internal sensor and the temperature of the sample liquid is approximately –2°C.
Software QIAGEN protocols are pre-installed on the QIAcube Connect.
Special feature Handheld scanner; Scan pattern: Area Image (838 x 640-pixel array); Motion tolerance: Up to 610 cm/s (240 in/s) for 13 mil UPC at optimal focus; Symbol contrast: 20% minimum reflectance difference; Decode capability: Reads standard 1D, PDF, 2D, Postal and OCR symbology
Storage conditions Temperature: 15ºC to 30ºC (59ºF to 86ºF) in manufacturer’s package; Relative humidity: Max. 75% (non-condensing); Environmental class: 1K2 (IEC 60721-3-1)
Table capacity Up to 12 samples per run
Technical data Power: 100–240 V AC, 50/60 Hz, 650 VA Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages. Note: The apparent power can exceed 650 VA for up to 2 seconds during the centrifuge acceleration and can reach an approximate value of 1000 VA.; Fuse: 2x T6.3A L 250V; Overvoltage category: II
Touchscreen 10.4” TFT Touchscreen, active area 211.2 x 158.4 mm, resolution 800*600 SVGA
Transportation conditions –25°C to 60°C (–13°F to 140°F) in manufacturer's package; Max. 75% relative humidity (non-condensing); Environmenal class: 2K2 (IEC 60721-3-2)
UV lamp Wavelength: 278nm; Optical power: 200-300mW

Product Resources

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FAQs (19)
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Application Notes (2)

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Extraction of microbiome DNA using the DNeasy PowerSoil Pro Kit manually and automated on the QIAcube Connect and QIAcube
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Instrument Technical Documents (1)
The QIAcube Connect System and 21 CFR Part 11 Regulations
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User-Developed Protocols (1)
This protocol has been adapted to allow the user to replace the epithelial transfer and sperm pellet wash steps with an automated protocol using the QIAcube Connect.
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