QIAGEN's HDplex STRs: Their Application to Forensic Analyses, Discrimination Power, and Patterns of Global Variation


The core short tandem repeats (STRs) in worldwide use have served the forensic analyst very well for many years. Further, recent expansions of European Standard STR sets plus ongoing discussions to extend CODIS have brought powerful upgrades to the battery of core markers available. However, there are still scenarios when supplementary STRs could enhance the data necessary for interpreting complex forensic patterns: making safer inferences about relatedness across distant relationships in deficient pedigrees, and in the not too distant future, improving the specificity of familial searching or expanding the points of reference to better interpret mixed profiles.

The QIAGEN HDplex Kit contains 9 completely novel STRs in addition to ESS or CODIS D12S39, D18S51 and SE33 markers. On an average, these 9 novel STRs provide higher powers of discrimination than kits using the core loci alone.

This webinar will outline the completed studies on worldwide patterns of variability in the 12 novel HDplex STRs and their ability to enhance the power of paternity analyses when combined with existing markers.
It will also describe the upgraded pop.STR allele frequency browser which provides data for 23 core STRs plus a total of 28 supplementary STRs in 56 global populations.

Join us to learn more on:

  • Enhancing data necessary for interpreting complex forensic patterns with supplementary STRs
  • Making safer inferences about relatedness across distant relationships in deficient pedigrees
  • Improving the specificity of familial searching to better interpret mixed profiles

Dr. Christopher Phillips

Dr. Christopher Phillips began his forensic genetics career in 1979 at the Metropolitan Police Forensic Science Laboratory, London. After 5 years in the service of “The Metlab”, he moved to the Forensic Haematology Department at Barts and the London School of Medicine and Dentistry and worked there until 2001. Since 2001 he has been a full-time researcher in the Forensic Genetics Unit of the Institute of Legal Medicine, University of Santiago de Compostela, Spain. His interests include SNP analysis applied to medical, population, and forensic genetics, the discovery and development of novel forensic markers, and building open-access online genomics search tools exemplified by pop.STR, SPSmart and the USC Snipper.