Using NGS to identify genetic causes of Alzheimer's disease
Recent research into the genetic causes of Alzheimer's disease point towards the common disease-rare variant hypothesis, suggesting that Alzheimer's disease has many different genetic causes, which individually may be rare in the population. This leads to a clear need to screen panels of genes to identify mutations that predispose to disease. Advances in NGS of DNA present the opportunity for massively parallel sequencing, which is ideally suited to meet this need.
QIAGEN technologies for NGS of DNA take the workflow all the way from sample collection, through target enrichment and library construction, to sequencing, annotation, and interpretation of data. NGS tools have the flexibility to integrate with any sequencing platform. Alzheimer's disease gene and mutation discovery will lead the way to a new era of disease screening, and add to the knowledge on the causes of neurodegeneration.