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The JCSG Core Suites

For initial screening using an optimized selection of conditions
  • Conditions for highest hit rates at the Joint Center for Structural Genomics
  • Optimized suites based on over half a million crystallization trials
  • Maximized reproducibility through online access to production reports
  • Available as tube or deep-well block formats

The JCSG Core Suites are split into 4 screens of 96 unique conditions in either deep-well blocks (1.5 ml per well) or tubes (10 ml), and are the result of analyzing over 500,000 high-throughput crystallization experiments performed at the JCSG. The 384 crystallization conditions that provided the highest hit rates in initial screening were chosen to form the screens.

Cat No./ID: 130724
NeXtal Tubes JCSG Core Suite I
$790.00
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96 x 10 ml tubes containing JCSG Core I Suite solutions
Cat No./ID: 130725
NeXtal Tubes JCSG Core Suite II
$790.00
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96 x 10 ml tubes containing JCSG Core II Suite solutions
Cat No./ID: 130726
NeXtal Tubes JCSG Core Suite III
$790.00
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96 x 10 ml tubes containing JCSG Core III Suite solutions
Cat No./ID: 130727
NeXtal Tubes JCSG Core Suite IV
$790.00
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96 x 10 ml tubes containing JCSG Core IV Suite solutions
Cat No./ID: 130924
NeXtal DWBlock JCSG Core Suite I
$326.00
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Pierceable deep-well block containing 96 x 1.5 ml JCSG Core Suite I solutions, piercing tool, adhesive foil
Cat No./ID: 130925
NeXtal DWBlock JCSG Core Suite II
$326.00
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Pierceable deep-well block containing 96 x 1.5 ml JCSG Core Suite II solutions, piercing tool, adhesive foil
Cat No./ID: 130926
NeXtal DWBlock JCSG Core Suite III
$326.00
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Pierceable deep-well block containing 96 x 1.5 ml JCSG Core Suite III solutions, piercing tool, adhesive foil
Cat No./ID: 130927
NeXtal DWBlock JCSG Core Suite IV
$326.00
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Pierceable deep-well block containing 96 x 1.5 ml JCSG Core Suite IV solutions, piercing tool, adhesive foil

The JCSG Core Suites are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease.


Principle

Obtaining protein crystals requires screening of a wide array of crystallization conditions. Starting with different sets of initial screening conditions, the search for a suitable condition can be narrowed down by further developing conditions centered around a promising condition that provides crystalline forms (i.e., “a hit”). The Core Suites include three different precipitant types (salts, organics, and polymers) used within three screening strategies (see table “Screening strategies”). The 384 crystallization conditions in the JCSG Core Suites offer a rapid and wide sampling of crystallization space. NeXtal Stock Solutions can be used to develop grids around your original hit conditions while working on the improvement of crystal size and quality.

Screening strategies

Grid screens

Systematically evaluating two factors 18%
Sparse matrix

Mapping a wide sector of crystallization conditions using many different chemicals

69%
Ionic sampling Evaluation of a selective precipitant versus various salt concentrations 13%
Applications

The JCSG Core Suites are higly suited for screening and improving initial crystallization conditions.

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