DNAseq Next-Generation Sequencing

Next Generation Sequencing
Using NGS to identify genetic causes of Alzheimer's disease
Recent research into the genetic causes of Alzheimer's disease point towards the common disease-rare variant hypothesis, suggesting that Alzheimer's disease has many different genetic causes, which individually may be rare in the population. This leads to a clear need to screen panels of genes to identify mutations that predispose to disease. Advances in NGS of DNA present the opportunity for massively parallel sequencing, which is ideally suited to meet this need. 

QIAGEN technologies for NGS of DNA take the workflow all the way from sample collection, through target enrichment and library construction, to sequencing, annotation, and interpretation of data. NGS tools have the flexibility to integrate with any sequencing platform. Alzheimer's disease gene and mutation discovery will lead the way to a new era of disease screening, and add to the knowledge on the causes of neurodegeneration.

For purification of up to 500 µg genomic DNA from whole blood
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For fully automated sample prep using QIAGEN spin-column kits
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For purification of DNA from tissues fixed and stabilized in PAXgene Tissue Containers
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For simultaneous purification of DNA and RNA from cells and tissues
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For purification of genomic DNA from formalin-fixed paraffin-embedded tissues
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For immediate stabilization of DNA, RNA, and protein in tissues
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For fixation and stabilization of human tissue specimens (max. 4 x 15 x 15 mm in size)
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For highly uniform whole genome amplification (WGA) from single cells or limited sample material
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For isolation of genomic, mitochondrial, bacterial, parasite or viral DNA
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For blood collection prior to genomic DNA purification using the PAXgene Blood DNA Kit
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For targeted enrichment of biologically and clinically relevant panels using any of 15 laboratory-verified primer sets prior to NGS
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For targeted enrichment of a customized set of genes or genomic regions specific for your NGS needs
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For qPCR-enabled quantification of NGS libraries before sequencing
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For fast and efficient preparation of DNA libraries for use in NGS applications
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For quick and reliable removal of DNA fragments <150 bp for library preparation in NGS applications
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For identifying disease-causing variants from human whole genome, exome and gene panel next-generation sequencing studies
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