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EasyXtal 15-Well Tools

For protein crystallization trial setup
  • Excellent optical properties and format for automatic visualization systems
  • Highly suitable for hit optimization and ligand screening
  • Unique, easy-to-open, greaseless, screw-in crystallization supports
  • Highly suitable for structure-based drug design optimization and screening

EasyXtal 15-Well Tools are used for manual setup of hanging-drop protein crystallization trials in microliter volumes. They are supplied as empty 15-well plates with a capacity of 500 μl of solution per reservoir well and 15 EasyXtal Standard, X-Seal, DropGuard, or DropGuard X-Seal crystallization supports to accommodate the protein drop. The greaseless screw-in crystallization supports are easy to open and close, facilitating crystallization screening and variation of crystallization conditions. The excellent optical properties and SBS footprint format of the EasyXtal 15-well tools makes them highly suitable for automatic visualization systems.

Cat No./ID: 132006
EasyXtal 15-Well Tool (20)
€323.00
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20 empty 15-well plates with standard crystallization supports
Cat No./ID: 132007
EasyXtal 15-Well Tool (100)
€1,451.00
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100 empty 15-well plates with standard crystallization supports
Cat No./ID: 132008
EasyXtal 15-Well Tool X-Seal (20)
€323.00
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20 empty 15-well plates with X-Seal crystallization supports
Cat No./ID: 132009
EasyXtal 15-Well Tool X-Seal (100)
€1,451.00
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100 empty 15-well plates with X-Seal crystallization supports
Cat No./ID: 132106
EasyXtal 15-Well DG-Tool (20)
€408.00
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20 empty 15-well plates with DropGuard crystallization supports
Cat No./ID: 132107
EasyXtal 15-Well DG-Tool (100)
€1,829.00
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100 empty 15-well plates with DropGuard crystallization supports
Cat No./ID: 132108
EasyXtal 15-Well DG-Tool X-Seal (20)
€408.00
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20 empty 15-well plates with DropGuard X-Seal crystallization supports
Cat No./ID: 132109
EasyXtal 15-Well DG-Tool X-Seal (100)
€1,829.00
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100 empty 15-well plates with DropGuard X-Seal crystallization supports

EasyXtal 15-Well Tools are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease.


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EasyXtal crystallization tools and supports.

[A] X-Seal Crystallization Support. [B] DropGuard Crystallization Support X-Seal.
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Setting up crystallization trials using DropGuard crystallization supports.
Performance

EasyXtal 15-well Tools are easy to use, high-performance protein crystallization devices. The 15-Well format is very useful for optimization experiments. The central well can serve as a control well containing the initial hit solution. The 14 wells around the central position can be used as a grid of systematic changes from the original solution (e.g., precipitant concentration or pH). This setup makes results easy to interpret.

Principle
EasyXtal 15-Well Tools are available with standard, X-Seal, DropGuard, or DropGuard X-Seal Crystallization Support (see figure "EasyXtal crystallization tools and supports"). The X-Seal, which is made from an advanced O-ring material, minimizes evaporation and prolongs the reuse of reservoir solutions. DropGuard crystallization supports enable easy setup of multiple drops per well and eliminate problems of drop spreading while using organic chemicals such as MPD or detergents. Three cavities in each support can be used to accommodate 1 μl + 1 μl drops or 2 μl + 2 μl drops. The cavities isolate drops and prevent contact among them, enabling easy recovery of crystals without disrupting neighboring drops (see figure "Setting up crystallization trials using DropGuard crystallization supports"). For larger protein drops (up to 5+5 µl), the standard crystallization supports are recommended.
Procedure

NeXtal Tubes offer Screening Solutions in a bulk format (10 ml tubes). The solutions can be used for manual setup of EasyXtal 15-well Tools by transferring 500 µl into the reservoir wells. Protein solution and reservoir solutions are pipetted onto the crystallization support which is then screwed onto the EasyXtal 15-well tool.

Applications

EasyXtal 15-Well Tools facilitate applications such as optimization and upscaling of successful hits obtained with 96-well formats, soaking with cryoprotectants or ligands, ligand screening in rational drug design procedures, and seeding experiments.

Features
Specifications
Format 15-well crystallization tools for upscaling and optimization of initial hits in hanging drop format
Processing Manual setup, automated readout possible

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