COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the most detailed and comprehensive resource for exploring the effect of somatic mutations in human cancer. In addition to coding mutations, COSMIC covers all the genetic mechanisms by which somatic mutations promote cancer, including non-coding mutations, gene fusions, copy-number variants and drug-resistance mutations.
The core COSMIC database is complemented by additional datasets that allow users to contextualize their detected biomarkers.
1. Cancer Gene Census presents an in-depth catalogue of all 723 genes that are causally implicated in cancer, along with their biological function and the description of their genetic mechanisms driving cancer.
2. Cancer Mutation Census provides information on the mutation significance of all coding mutations based on biological and biochemical information from multiple sources.
3. Mutation Actionability in Precision Oncology (Actionability) provides up-to-date information about drugs that target specific somatic mutations at all stages of development.
4. Cell Lines Project puts forward cell line 'omics data through systematic characterization of the genetics and genomics (alterations and gene expression) of 1020 cancer cell lines.